Fotoféresis en el tratamiento de Síndrome de Sézary: Caso clínico

Sézary syndrome (SS) is an unusually aggressive T- cell lymphoma characterized by the triad of erythroderma, the presence of more than 1,000 Sézary cells in peripheral blood and lymphadenopathies. It is accompanied by generalized pruritus and poor quality of life. The management of SS depends on its...

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Autores principales:	Molgó,Montserrat, Jaque,Alejandra, Vial,Verónica, Ocqueteau,Mauricio, Pereira,Jaime, Chang,Mayling, González,Sergio
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2015
Materias:	Lyphoma, T cell Sézary Syndrome Photopheresis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872015001100011
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spelling	oai:scielo:S0034-988720150011000112016-01-19Fotoféresis en el tratamiento de Síndrome de Sézary: Caso clínicoMolgó,MontserratJaque,AlejandraVial,VerónicaOcqueteau,MauricioPereira,JaimeChang,MaylingGonzález,Sergio Lyphoma, T cell Sézary Syndrome Photopheresis Sézary syndrome (SS) is an unusually aggressive T- cell lymphoma characterized by the triad of erythroderma, the presence of more than 1,000 Sézary cells in peripheral blood and lymphadenopathies. It is accompanied by generalized pruritus and poor quality of life. The management of SS depends on its stage, patient comorbidities, and treatment availability. Extracorporeal photopheresis (ECP) is the first line of treatment for patients with T-cell lymphomas in stage IVA1, IVA2 or SS. This treatment comprises three phases: leukapheresis, photoactivation and subsequent reinfusion of lymphocytes. As it is an immunomodulatory therapy it does not produce generalized immunosuppression. We report a 76 year-old male with SS stage IIIb initially treated with 12 sessions of ultraviolet phototherapy without response. After 10 well-tolerated sessions of ECP, itching and skin lesions eventually disappeared.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.143 n.11 20152015-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872015001100011es10.4067/S0034-98872015001100011
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Lyphoma, T cell Sézary Syndrome Photopheresis
spellingShingle	Lyphoma, T cell Sézary Syndrome Photopheresis Molgó,Montserrat Jaque,Alejandra Vial,Verónica Ocqueteau,Mauricio Pereira,Jaime Chang,Mayling González,Sergio Fotoféresis en el tratamiento de Síndrome de Sézary: Caso clínico
description	Sézary syndrome (SS) is an unusually aggressive T- cell lymphoma characterized by the triad of erythroderma, the presence of more than 1,000 Sézary cells in peripheral blood and lymphadenopathies. It is accompanied by generalized pruritus and poor quality of life. The management of SS depends on its stage, patient comorbidities, and treatment availability. Extracorporeal photopheresis (ECP) is the first line of treatment for patients with T-cell lymphomas in stage IVA1, IVA2 or SS. This treatment comprises three phases: leukapheresis, photoactivation and subsequent reinfusion of lymphocytes. As it is an immunomodulatory therapy it does not produce generalized immunosuppression. We report a 76 year-old male with SS stage IIIb initially treated with 12 sessions of ultraviolet phototherapy without response. After 10 well-tolerated sessions of ECP, itching and skin lesions eventually disappeared.
author	Molgó,Montserrat Jaque,Alejandra Vial,Verónica Ocqueteau,Mauricio Pereira,Jaime Chang,Mayling González,Sergio
author_facet	Molgó,Montserrat Jaque,Alejandra Vial,Verónica Ocqueteau,Mauricio Pereira,Jaime Chang,Mayling González,Sergio
author_sort	Molgó,Montserrat
title	Fotoféresis en el tratamiento de Síndrome de Sézary: Caso clínico
title_short	Fotoféresis en el tratamiento de Síndrome de Sézary: Caso clínico
title_full	Fotoféresis en el tratamiento de Síndrome de Sézary: Caso clínico
title_fullStr	Fotoféresis en el tratamiento de Síndrome de Sézary: Caso clínico
title_full_unstemmed	Fotoféresis en el tratamiento de Síndrome de Sézary: Caso clínico
title_sort	fotoféresis en el tratamiento de síndrome de sézary: caso clínico
publisher	Sociedad Médica de Santiago
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872015001100011
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Fotoféresis en el tratamiento de Síndrome de Sézary: Caso clínico

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