Leucoencefalopatía tóxica fatal: tres casos asociados al consumo de pasta base de cocaína

The prevalence of drug-associated toxic encephalopathy is unknown, but it is an uncommon condition. Toxic leukoencephalopathy was described associated with heroin consumption, it has been less commonly described with the use of cocaine and there are no reports of its association with consumption pas...

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Autores principales:	Cartier R,Luis, González L,Daniela, Harán D,Jorge
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2015
Materias:	Cocaine Leukpencephalopaties Spongy degeneration of the brain
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872015001100015
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spelling	oai:scielo:S0034-988720150011000152016-01-19Leucoencefalopatía tóxica fatal: tres casos asociados al consumo de pasta base de cocaínaCartier R,LuisGonzález L,DanielaHarán D,Jorge Cocaine Leukpencephalopaties Spongy degeneration of the brain The prevalence of drug-associated toxic encephalopathy is unknown, but it is an uncommon condition. Toxic leukoencephalopathy was described associated with heroin consumption, it has been less commonly described with the use of cocaine and there are no reports of its association with consumption pasta base of cocaine (PBC). We report two females aged 31 years and a male aged 19 years, consumers of PBC who developed a fatal toxic leukoencephalopathy. They initiated their disease with severe and persistent headache, sequential focal neurologic deficits and a progressive impairment of consciousness that culminated with their death. Laboratory parameters such as blood count, cerebrospinal fluid analyses or infectious biological indices were normal. MRI showed multifocal lesions in brain white matter of both hemispheres confirming the leukoencephalopathy. There was no response to the use of methylprednisolone.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.143 n.11 20152015-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872015001100015es10.4067/S0034-98872015001100015
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Cocaine Leukpencephalopaties Spongy degeneration of the brain
spellingShingle	Cocaine Leukpencephalopaties Spongy degeneration of the brain Cartier R,Luis González L,Daniela Harán D,Jorge Leucoencefalopatía tóxica fatal: tres casos asociados al consumo de pasta base de cocaína
description	The prevalence of drug-associated toxic encephalopathy is unknown, but it is an uncommon condition. Toxic leukoencephalopathy was described associated with heroin consumption, it has been less commonly described with the use of cocaine and there are no reports of its association with consumption pasta base of cocaine (PBC). We report two females aged 31 years and a male aged 19 years, consumers of PBC who developed a fatal toxic leukoencephalopathy. They initiated their disease with severe and persistent headache, sequential focal neurologic deficits and a progressive impairment of consciousness that culminated with their death. Laboratory parameters such as blood count, cerebrospinal fluid analyses or infectious biological indices were normal. MRI showed multifocal lesions in brain white matter of both hemispheres confirming the leukoencephalopathy. There was no response to the use of methylprednisolone.
author	Cartier R,Luis González L,Daniela Harán D,Jorge
author_facet	Cartier R,Luis González L,Daniela Harán D,Jorge
author_sort	Cartier R,Luis
title	Leucoencefalopatía tóxica fatal: tres casos asociados al consumo de pasta base de cocaína
title_short	Leucoencefalopatía tóxica fatal: tres casos asociados al consumo de pasta base de cocaína
title_full	Leucoencefalopatía tóxica fatal: tres casos asociados al consumo de pasta base de cocaína
title_fullStr	Leucoencefalopatía tóxica fatal: tres casos asociados al consumo de pasta base de cocaína
title_full_unstemmed	Leucoencefalopatía tóxica fatal: tres casos asociados al consumo de pasta base de cocaína
title_sort	leucoencefalopatía tóxica fatal: tres casos asociados al consumo de pasta base de cocaína
publisher	Sociedad Médica de Santiago
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872015001100015
work_keys_str_mv	AT cartierrluis leucoencefalopatiatoxicafataltrescasosasociadosalconsumodepastabasedecocaina AT gonzalezldaniela leucoencefalopatiatoxicafataltrescasosasociadosalconsumodepastabasedecocaina AT harandjorge leucoencefalopatiatoxicafataltrescasosasociadosalconsumodepastabasedecocaina
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Leucoencefalopatía tóxica fatal: tres casos asociados al consumo de pasta base de cocaína

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