Búsqueda activa de enfermedad celíaca en familiares de primer grado de casos celíacos

Background: Active search of celiac disease (CD) among risk groups has significantly increased the scope of known clinical variants. Aim: To measure the frequency and clinical characteristics of CD among first degree relatives (FDR) of known celiac cases. Material and Methods: Between January 2012-A...

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Autores principales:	Bejares,Marcela, Oyarzún,Amaya, Lucero,Yalda, Espinoza,Nelly, Bascuñán,Karla, Araya,Magdalena
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2015
Materias:	Celiac Disease Immunoglobulin A Transglutaminase 2, human
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872015001200003
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spelling	oai:scielo:S0034-988720150012000032016-02-29Búsqueda activa de enfermedad celíaca en familiares de primer grado de casos celíacosBejares,MarcelaOyarzún,AmayaLucero,YaldaEspinoza,NellyBascuñán,KarlaAraya,Magdalena Celiac Disease Immunoglobulin A Transglutaminase 2, human Background: Active search of celiac disease (CD) among risk groups has significantly increased the scope of known clinical variants. Aim: To measure the frequency and clinical characteristics of CD among first degree relatives (FDR) of known celiac cases. Material and Methods: Between January 2012-August 2013, 37 patients with celiac disease brought 113 FDR for assessment. Their clinical data was recorded and a blood sample was obtained to measure serum Immunoglobulin A (IgA) levels, anti-transglutaminase (tTG) and anti-endomisial (EMA) antibodies. Cases with positive serology were advised to have an intestinal biopsy. Results: Fourteen relatives (12.4%) had positive serological results and none had IgA deficiency. Among IgA-tTG (-) cases, measurement of IgA/IgG-tTG identified an additional case. Two of the 14 relatives were EMA positive. All 14 cases were advised to have an intestinal biopsy, but only 6 accepted the procedure. In two, the intestinal lesion was classified Marsh ≥ 2 and active CD was diagnosed. Histology in the remaining four was Marsh 0/1 and were diagnosed potential CD, remaining under control, without gluten free diet. Conclusions: Serological prevalence of CD among first degree relatives of known celiac cases was 15 fold greater than in THE general Chilean population, strongly supporting the idea of implementing active search to customary clinical practice. Determination of IgA/IgG-tTG may be useful to improve the yield of active search. Intestinal biopsies were crucial to differentiate active classic CD from potential CD.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.143 n.12 20152015-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872015001200003es10.4067/S0034-98872015001200003
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Celiac Disease Immunoglobulin A Transglutaminase 2, human
spellingShingle	Celiac Disease Immunoglobulin A Transglutaminase 2, human Bejares,Marcela Oyarzún,Amaya Lucero,Yalda Espinoza,Nelly Bascuñán,Karla Araya,Magdalena Búsqueda activa de enfermedad celíaca en familiares de primer grado de casos celíacos
description	Background: Active search of celiac disease (CD) among risk groups has significantly increased the scope of known clinical variants. Aim: To measure the frequency and clinical characteristics of CD among first degree relatives (FDR) of known celiac cases. Material and Methods: Between January 2012-August 2013, 37 patients with celiac disease brought 113 FDR for assessment. Their clinical data was recorded and a blood sample was obtained to measure serum Immunoglobulin A (IgA) levels, anti-transglutaminase (tTG) and anti-endomisial (EMA) antibodies. Cases with positive serology were advised to have an intestinal biopsy. Results: Fourteen relatives (12.4%) had positive serological results and none had IgA deficiency. Among IgA-tTG (-) cases, measurement of IgA/IgG-tTG identified an additional case. Two of the 14 relatives were EMA positive. All 14 cases were advised to have an intestinal biopsy, but only 6 accepted the procedure. In two, the intestinal lesion was classified Marsh ≥ 2 and active CD was diagnosed. Histology in the remaining four was Marsh 0/1 and were diagnosed potential CD, remaining under control, without gluten free diet. Conclusions: Serological prevalence of CD among first degree relatives of known celiac cases was 15 fold greater than in THE general Chilean population, strongly supporting the idea of implementing active search to customary clinical practice. Determination of IgA/IgG-tTG may be useful to improve the yield of active search. Intestinal biopsies were crucial to differentiate active classic CD from potential CD.
author	Bejares,Marcela Oyarzún,Amaya Lucero,Yalda Espinoza,Nelly Bascuñán,Karla Araya,Magdalena
author_facet	Bejares,Marcela Oyarzún,Amaya Lucero,Yalda Espinoza,Nelly Bascuñán,Karla Araya,Magdalena
author_sort	Bejares,Marcela
title	Búsqueda activa de enfermedad celíaca en familiares de primer grado de casos celíacos
title_short	Búsqueda activa de enfermedad celíaca en familiares de primer grado de casos celíacos
title_full	Búsqueda activa de enfermedad celíaca en familiares de primer grado de casos celíacos
title_fullStr	Búsqueda activa de enfermedad celíaca en familiares de primer grado de casos celíacos
title_full_unstemmed	Búsqueda activa de enfermedad celíaca en familiares de primer grado de casos celíacos
title_sort	búsqueda activa de enfermedad celíaca en familiares de primer grado de casos celíacos
publisher	Sociedad Médica de Santiago
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872015001200003
work_keys_str_mv	AT bejaresmarcela busquedaactivadeenfermedadceliacaenfamiliaresdeprimergradodecasosceliacos AT oyarzunamaya busquedaactivadeenfermedadceliacaenfamiliaresdeprimergradodecasosceliacos AT luceroyalda busquedaactivadeenfermedadceliacaenfamiliaresdeprimergradodecasosceliacos AT espinozanelly busquedaactivadeenfermedadceliacaenfamiliaresdeprimergradodecasosceliacos AT bascunankarla busquedaactivadeenfermedadceliacaenfamiliaresdeprimergradodecasosceliacos AT arayamagdalena busquedaactivadeenfermedadceliacaenfamiliaresdeprimergradodecasosceliacos
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Búsqueda activa de enfermedad celíaca en familiares de primer grado de casos celíacos

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