MicroRNAs: Marcadores séricos en diabetes mellitus tipo 2 y ejercicio físico

MicroRNAs are small, non-coding molecules with a crucial function in the cell´s biologic regulation. Circulating levels of miRNAs may be useful biomarkers in metabolic diseases such as type 2 Diabetes Mellitus (DM2), which alters the circulating concentrations of several types of miRNA. Specific ser...

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Autores principales:	Gómez-Banoy,Nicolás, Mockus,Ismena
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2016
Materias:	Diabetes Mellitus Type 2 Exercise MicroRNAs
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000300011
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spelling	oai:scielo:S0034-988720160003000112016-06-13MicroRNAs: Marcadores séricos en diabetes mellitus tipo 2 y ejercicio físicoGómez-Banoy,NicolásMockus,Ismena Diabetes Mellitus Type 2 Exercise MicroRNAs MicroRNAs are small, non-coding molecules with a crucial function in the cell´s biologic regulation. Circulating levels of miRNAs may be useful biomarkers in metabolic diseases such as type 2 Diabetes Mellitus (DM2), which alters the circulating concentrations of several types of miRNA. Specific serum profiles of these molecules have been identified in high-risk patients before the development of DM2 and its chronic complications. Most importantly, these profiles can be modified with physical exercise, which is crucial in the treatment of metabolic diseases. Acute physical activity alone can induce changes in tissue specific miRNAs, and responses are different in aerobic or non-aerobic training. Muscle and cardiovascular miRNAs, which may play an important role in the adap tation to exercise, are predominantly altered. Even further, there is a correlation between serum levels of miRNAs and fitness, suggesting a role for chronic exercise in their regulation. Thus, miRNAs are molecules of growing importance in exercise physiology, and may be involved in the mechanisms behind the beneficial effects of physical activity for patients with metabolic diseases.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.144 n.3 20162016-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000300011es10.4067/S0034-98872016000300011
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Diabetes Mellitus Type 2 Exercise MicroRNAs
spellingShingle	Diabetes Mellitus Type 2 Exercise MicroRNAs Gómez-Banoy,Nicolás Mockus,Ismena MicroRNAs: Marcadores séricos en diabetes mellitus tipo 2 y ejercicio físico
description	MicroRNAs are small, non-coding molecules with a crucial function in the cell´s biologic regulation. Circulating levels of miRNAs may be useful biomarkers in metabolic diseases such as type 2 Diabetes Mellitus (DM2), which alters the circulating concentrations of several types of miRNA. Specific serum profiles of these molecules have been identified in high-risk patients before the development of DM2 and its chronic complications. Most importantly, these profiles can be modified with physical exercise, which is crucial in the treatment of metabolic diseases. Acute physical activity alone can induce changes in tissue specific miRNAs, and responses are different in aerobic or non-aerobic training. Muscle and cardiovascular miRNAs, which may play an important role in the adap tation to exercise, are predominantly altered. Even further, there is a correlation between serum levels of miRNAs and fitness, suggesting a role for chronic exercise in their regulation. Thus, miRNAs are molecules of growing importance in exercise physiology, and may be involved in the mechanisms behind the beneficial effects of physical activity for patients with metabolic diseases.
author	Gómez-Banoy,Nicolás Mockus,Ismena
author_facet	Gómez-Banoy,Nicolás Mockus,Ismena
author_sort	Gómez-Banoy,Nicolás
title	MicroRNAs: Marcadores séricos en diabetes mellitus tipo 2 y ejercicio físico
title_short	MicroRNAs: Marcadores séricos en diabetes mellitus tipo 2 y ejercicio físico
title_full	MicroRNAs: Marcadores séricos en diabetes mellitus tipo 2 y ejercicio físico
title_fullStr	MicroRNAs: Marcadores séricos en diabetes mellitus tipo 2 y ejercicio físico
title_full_unstemmed	MicroRNAs: Marcadores séricos en diabetes mellitus tipo 2 y ejercicio físico
title_sort	micrornas: marcadores séricos en diabetes mellitus tipo 2 y ejercicio físico
publisher	Sociedad Médica de Santiago
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000300011
work_keys_str_mv	AT gomezbanoynicolas micrornasmarcadoressericosendiabetesmellitustipo2yejerciciofisico AT mockusismena micrornasmarcadoressericosendiabetesmellitustipo2yejerciciofisico
_version_	1718436872095531008

MicroRNAs: Marcadores séricos en diabetes mellitus tipo 2 y ejercicio físico

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