Compromiso óseo en mastocitosis sistémica: una asociación frecuente, pero muchas veces inadvertida

Systemic mastocytosis (SM) is characterized by pathologic expansion and activation of mast cells. The main clinical manifestations of SM include skin involvement, gastrointestinal symptoms and anaphylaxis due to the release of its mediators. Thirty percent of pat ients with SM have a low bone mass a...

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Autores principales:	Florenzano,Pablo, Mezzano,Verónica, Le-Bert,Marcela, González,Gilberto
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2016
Materias:	Fractures Mastocytosis Osteoporosis Systemic
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000300018
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spelling	oai:scielo:S0034-988720160003000182016-06-13Compromiso óseo en mastocitosis sistémica: una asociación frecuente, pero muchas veces inadvertidaFlorenzano,PabloMezzano,VerónicaLe-Bert,MarcelaGonzález,Gilberto Fractures Mastocytosis Osteoporosis Systemic Systemic mastocytosis (SM) is characterized by pathologic expansion and activation of mast cells. The main clinical manifestations of SM include skin involvement, gastrointestinal symptoms and anaphylaxis due to the release of its mediators. Thirty percent of pat ients with SM have a low bone mass and 20% fractures. At the same time, SM affects 10% of male patients with idiopathic osteoporosis. Measuring serum tryptase is essential for the screening of MS. We report two cases of SM with bone involvement. A 25-year- old woman with prior diagnosis of SM, based on skin involvement, flushing, high serum tryptase and compatible bone marrow (BM) biopsy and genetic study. Low bone mass was diagnosed and treatment was started with calcium and vitamin D plus oral bisphosphona tes with adequate response. A 47 years old man who presented with multiple osteoporotic vertebral fractures and low bone mass. Treatment with vitamin D and alendronate was started, but the patient developed new vertebral fractures. The study was extended w ith measurement of serum tryptase that was elevated. Diagnosis of SM was confirmed with BM biopsy and the patient was referred to hematology for specific care. These cases emphasize the importance of bone assessment in SM, as well as the need to rule out S M in patients with osteoporosis and no evident cause.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.144 n.3 20162016-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000300018es10.4067/S0034-98872016000300018
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Fractures Mastocytosis Osteoporosis Systemic
spellingShingle	Fractures Mastocytosis Osteoporosis Systemic Florenzano,Pablo Mezzano,Verónica Le-Bert,Marcela González,Gilberto Compromiso óseo en mastocitosis sistémica: una asociación frecuente, pero muchas veces inadvertida
description	Systemic mastocytosis (SM) is characterized by pathologic expansion and activation of mast cells. The main clinical manifestations of SM include skin involvement, gastrointestinal symptoms and anaphylaxis due to the release of its mediators. Thirty percent of pat ients with SM have a low bone mass and 20% fractures. At the same time, SM affects 10% of male patients with idiopathic osteoporosis. Measuring serum tryptase is essential for the screening of MS. We report two cases of SM with bone involvement. A 25-year- old woman with prior diagnosis of SM, based on skin involvement, flushing, high serum tryptase and compatible bone marrow (BM) biopsy and genetic study. Low bone mass was diagnosed and treatment was started with calcium and vitamin D plus oral bisphosphona tes with adequate response. A 47 years old man who presented with multiple osteoporotic vertebral fractures and low bone mass. Treatment with vitamin D and alendronate was started, but the patient developed new vertebral fractures. The study was extended w ith measurement of serum tryptase that was elevated. Diagnosis of SM was confirmed with BM biopsy and the patient was referred to hematology for specific care. These cases emphasize the importance of bone assessment in SM, as well as the need to rule out S M in patients with osteoporosis and no evident cause.
author	Florenzano,Pablo Mezzano,Verónica Le-Bert,Marcela González,Gilberto
author_facet	Florenzano,Pablo Mezzano,Verónica Le-Bert,Marcela González,Gilberto
author_sort	Florenzano,Pablo
title	Compromiso óseo en mastocitosis sistémica: una asociación frecuente, pero muchas veces inadvertida
title_short	Compromiso óseo en mastocitosis sistémica: una asociación frecuente, pero muchas veces inadvertida
title_full	Compromiso óseo en mastocitosis sistémica: una asociación frecuente, pero muchas veces inadvertida
title_fullStr	Compromiso óseo en mastocitosis sistémica: una asociación frecuente, pero muchas veces inadvertida
title_full_unstemmed	Compromiso óseo en mastocitosis sistémica: una asociación frecuente, pero muchas veces inadvertida
title_sort	compromiso óseo en mastocitosis sistémica: una asociación frecuente, pero muchas veces inadvertida
publisher	Sociedad Médica de Santiago
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000300018
work_keys_str_mv	AT florenzanopablo compromisooseoenmastocitosissistemicaunaasociacionfrecuenteperomuchasvecesinadvertida AT mezzanoveronica compromisooseoenmastocitosissistemicaunaasociacionfrecuenteperomuchasvecesinadvertida AT lebertmarcela compromisooseoenmastocitosissistemicaunaasociacionfrecuenteperomuchasvecesinadvertida AT gonzalezgilberto compromisooseoenmastocitosissistemicaunaasociacionfrecuenteperomuchasvecesinadvertida
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Compromiso óseo en mastocitosis sistémica: una asociación frecuente, pero muchas veces inadvertida

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