Reversion of methacholine induced bronchoconstriction with inhaled diazepam in patients with asthma

Background: Benzodiazepines have a direct bronchodilatory effect. Methacholine is a non-selective muscarinic receptor agonist causing bronchoconstriction. Aim: To examine the effects of inhaled benzodiazepines, modulating bronchoconstriction induced by methacholine in patients with asthma. Patients...

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Autores principales:	Miric,Mirjana, Ristic,Sinisa, Joksimovic,Bojan N, Medenica,Snezana, Racic,Maja, Ristic,Slavica, Joksimovic,Vedrana R, Skipina,Mirjana
Lenguaje:	English
Publicado:	Sociedad Médica de Santiago 2016
Materias:	Benzodiazepines Bronchoconstriction Diazepam Methacholine Chloride
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000400003
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spelling	oai:scielo:S0034-988720160004000032016-07-01Reversion of methacholine induced bronchoconstriction with inhaled diazepam in patients with asthmaMiric,MirjanaRistic,SinisaJoksimovic,Bojan NMedenica,SnezanaRacic,MajaRistic,SlavicaJoksimovic,Vedrana RSkipina,Mirjana Benzodiazepines Bronchoconstriction Diazepam Methacholine Chloride Background: Benzodiazepines have a direct bronchodilatory effect. Methacholine is a non-selective muscarinic receptor agonist causing bronchoconstriction. Aim: To examine the effects of inhaled benzodiazepines, modulating bronchoconstriction induced by methacholine in patients with asthma. Patients and Methods: Twelve patients with well controlled asthma were studied. On the first day, after determining the initial values of pulmonary function, a dose response curve was carried out with progressive doses of methacholine. After the last dose, when at least a 20% drop of the initial forced expiratory volume in the first second (FEV1) was achieved, vital capacity (VC) and FEV1 were measured at 7, 15 and 30 minutes after provocation. On the second day a diazepam aerosol was inhaled by the patients prior to the same protocol with methacholine. Results: In the first day of testing, methacholine inhalation (6 mg/mL) led to a significant drop in FEV1 from 2.98 to 1.69 L. On the second day of study, in the same patients, previous inhalation with diazepam reduced the changes of FEV1 after inhalation of methacholine. This parameter decreased from 2.48 to 2.21 L. Conclusions: Inhalation of benzodiazepines reduce bronchoconstriction after a methacholine challenge in patients with asthma.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.144 n.4 20162016-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000400003en10.4067/S0034-98872016000400003
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Benzodiazepines Bronchoconstriction Diazepam Methacholine Chloride
spellingShingle	Benzodiazepines Bronchoconstriction Diazepam Methacholine Chloride Miric,Mirjana Ristic,Sinisa Joksimovic,Bojan N Medenica,Snezana Racic,Maja Ristic,Slavica Joksimovic,Vedrana R Skipina,Mirjana Reversion of methacholine induced bronchoconstriction with inhaled diazepam in patients with asthma
description	Background: Benzodiazepines have a direct bronchodilatory effect. Methacholine is a non-selective muscarinic receptor agonist causing bronchoconstriction. Aim: To examine the effects of inhaled benzodiazepines, modulating bronchoconstriction induced by methacholine in patients with asthma. Patients and Methods: Twelve patients with well controlled asthma were studied. On the first day, after determining the initial values of pulmonary function, a dose response curve was carried out with progressive doses of methacholine. After the last dose, when at least a 20% drop of the initial forced expiratory volume in the first second (FEV1) was achieved, vital capacity (VC) and FEV1 were measured at 7, 15 and 30 minutes after provocation. On the second day a diazepam aerosol was inhaled by the patients prior to the same protocol with methacholine. Results: In the first day of testing, methacholine inhalation (6 mg/mL) led to a significant drop in FEV1 from 2.98 to 1.69 L. On the second day of study, in the same patients, previous inhalation with diazepam reduced the changes of FEV1 after inhalation of methacholine. This parameter decreased from 2.48 to 2.21 L. Conclusions: Inhalation of benzodiazepines reduce bronchoconstriction after a methacholine challenge in patients with asthma.
author	Miric,Mirjana Ristic,Sinisa Joksimovic,Bojan N Medenica,Snezana Racic,Maja Ristic,Slavica Joksimovic,Vedrana R Skipina,Mirjana
author_facet	Miric,Mirjana Ristic,Sinisa Joksimovic,Bojan N Medenica,Snezana Racic,Maja Ristic,Slavica Joksimovic,Vedrana R Skipina,Mirjana
author_sort	Miric,Mirjana
title	Reversion of methacholine induced bronchoconstriction with inhaled diazepam in patients with asthma
title_short	Reversion of methacholine induced bronchoconstriction with inhaled diazepam in patients with asthma
title_full	Reversion of methacholine induced bronchoconstriction with inhaled diazepam in patients with asthma
title_fullStr	Reversion of methacholine induced bronchoconstriction with inhaled diazepam in patients with asthma
title_full_unstemmed	Reversion of methacholine induced bronchoconstriction with inhaled diazepam in patients with asthma
title_sort	reversion of methacholine induced bronchoconstriction with inhaled diazepam in patients with asthma
publisher	Sociedad Médica de Santiago
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000400003
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Reversion of methacholine induced bronchoconstriction with inhaled diazepam in patients with asthma

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