Leucopatía reversible de la protuberancia: en paciente con SIDA y tratamiento retroviral

Posterior reversible encephalopathy (PRES) is a condition characterized by T2 and FLAIR hyperintensities in magnetic resonance imaging (MRI) studies, localized preferentially in the occipital-parietal white matter regions. Pathological MRI images located in midbrain, pons, medulla and spinal cord, t...

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Autores principales:	Cartier,Luis, Matamala,José Manuel, Yáñez,Alonso
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2016
Materias:	Acquired Immunodeficiency Syndrome Antiretroviral Therapy, Highly Active Myelinolysis, Central Pontine Posterior Leukoencephalopathy Syndrome
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000500018
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spelling	oai:scielo:S0034-988720160005000182016-08-31Leucopatía reversible de la protuberancia: en paciente con SIDA y tratamiento retroviralCartier,LuisMatamala,José ManuelYáñez,Alonso Acquired Immunodeficiency Syndrome Antiretroviral Therapy, Highly Active Myelinolysis, Central Pontine Posterior Leukoencephalopathy Syndrome Posterior reversible encephalopathy (PRES) is a condition characterized by T2 and FLAIR hyperintensities in magnetic resonance imaging (MRI) studies, localized preferentially in the occipital-parietal white matter regions. Pathological MRI images located in midbrain, pons, medulla and spinal cord, that could be asymptomatic, were recently included in this entity. These images are interpreted as vasogenic edema, which is caused by arterial hypertension or eclampsia, neurotoxicity related to immunosuppressive agents or chemotherapy, among other causes. We report a 25 years old asymptomatic male with AIDS, with normal blood pressure who after initiating highly active antiretroviral therapy (HAART) reported vertigo. The MRI showed a central pontine T2 hyperintensity with diffusion restriction, which was interpreted as a central pontine myelinolysis (CPM), but the lack of motor symptoms made improbable a real demyelination of the pons. The follow-up MRI revealed complete regression of the images. To our knowledge, this case could be the second report of a reversible leucopathy of the pons in a patient with AIDS, were the MRI images also simulated a CPM. This report extends the knowledge around the variability of the pathogenic interpretation of CPM images and their association with HAART.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.144 n.5 20162016-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000500018es10.4067/S0034-98872016000500018
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Acquired Immunodeficiency Syndrome Antiretroviral Therapy, Highly Active Myelinolysis, Central Pontine Posterior Leukoencephalopathy Syndrome
spellingShingle	Acquired Immunodeficiency Syndrome Antiretroviral Therapy, Highly Active Myelinolysis, Central Pontine Posterior Leukoencephalopathy Syndrome Cartier,Luis Matamala,José Manuel Yáñez,Alonso Leucopatía reversible de la protuberancia: en paciente con SIDA y tratamiento retroviral
description	Posterior reversible encephalopathy (PRES) is a condition characterized by T2 and FLAIR hyperintensities in magnetic resonance imaging (MRI) studies, localized preferentially in the occipital-parietal white matter regions. Pathological MRI images located in midbrain, pons, medulla and spinal cord, that could be asymptomatic, were recently included in this entity. These images are interpreted as vasogenic edema, which is caused by arterial hypertension or eclampsia, neurotoxicity related to immunosuppressive agents or chemotherapy, among other causes. We report a 25 years old asymptomatic male with AIDS, with normal blood pressure who after initiating highly active antiretroviral therapy (HAART) reported vertigo. The MRI showed a central pontine T2 hyperintensity with diffusion restriction, which was interpreted as a central pontine myelinolysis (CPM), but the lack of motor symptoms made improbable a real demyelination of the pons. The follow-up MRI revealed complete regression of the images. To our knowledge, this case could be the second report of a reversible leucopathy of the pons in a patient with AIDS, were the MRI images also simulated a CPM. This report extends the knowledge around the variability of the pathogenic interpretation of CPM images and their association with HAART.
author	Cartier,Luis Matamala,José Manuel Yáñez,Alonso
author_facet	Cartier,Luis Matamala,José Manuel Yáñez,Alonso
author_sort	Cartier,Luis
title	Leucopatía reversible de la protuberancia: en paciente con SIDA y tratamiento retroviral
title_short	Leucopatía reversible de la protuberancia: en paciente con SIDA y tratamiento retroviral
title_full	Leucopatía reversible de la protuberancia: en paciente con SIDA y tratamiento retroviral
title_fullStr	Leucopatía reversible de la protuberancia: en paciente con SIDA y tratamiento retroviral
title_full_unstemmed	Leucopatía reversible de la protuberancia: en paciente con SIDA y tratamiento retroviral
title_sort	leucopatía reversible de la protuberancia: en paciente con sida y tratamiento retroviral
publisher	Sociedad Médica de Santiago
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000500018
work_keys_str_mv	AT cartierluis leucopatiareversibledelaprotuberanciaenpacienteconsidaytratamientoretroviral AT matamalajosemanuel leucopatiareversibledelaprotuberanciaenpacienteconsidaytratamientoretroviral AT yanezalonso leucopatiareversibledelaprotuberanciaenpacienteconsidaytratamientoretroviral
_version_	1718436885486895104

Leucopatía reversible de la protuberancia: en paciente con SIDA y tratamiento retroviral

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