Plomo y nefropatía: Biomarcadores urinarios en la detección de daño renal precoz

The role of lead (Pb) as an environmental cause of nephropathy is difficult to ascertain due to the difficulty to determine clinically its exposure. Aim: To assess lead levels and renal function in a group of males working in mechanical workshops. Material and Methods: Blood and urine samples were o...

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Autores principales:	Cabrera,Walter E, Behets,Geert, Lamberts,Ludwig, D'Haese,Patrick
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2016
Materias:	Biomarkers Environmental Exposure Kidney Failure Chronic Lead
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000600003
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spelling	oai:scielo:S0034-988720160006000032016-10-03Plomo y nefropatía: Biomarcadores urinarios en la detección de daño renal precozCabrera,Walter EBehets,GeertLamberts,LudwigD'Haese,Patrick Biomarkers Environmental Exposure Kidney Failure Chronic Lead The role of lead (Pb) as an environmental cause of nephropathy is difficult to ascertain due to the difficulty to determine clinically its exposure. Aim: To assess lead levels and renal function in a group of males working in mechanical workshops. Material and Methods: Blood and urine samples were obtained from 100 mechanical workshop workers aged 38 ± 16 years and 95 non-exposed office clerks aged 37 ± 17 years. Blood lead and creatinine levels were determined. In exposed workers, urinary excretion of intestinal alkaline phosphatases (IAP) and N-acetyl-glucosaminidase (NAG) were measured as early markers of renal failure. Results: Blood lead levels were 66.4 ± 43 and 33.6 ± 18 µg/L among mechanical workshop workers and non-exposed controls, respectively, p < 0.01. The figures for serum creatinine were 0.9 ± 0.1 and 0.9 ± 0.1 respectively, p = NS. Among exposed workers urinary excretion of IAP was 0.47 ± 0.6 U/L and of NAG, 0.92 ± 1.1 U/L. There was a positive correlation between blood lead levels and NAG excretion (r = 0.284) and IAP excretion (r = 0.346). Conclusions: Exposed workers had higher blood lead levels and there was a weak positive association between these levels and the urinary excretion of NAG and IAP.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.144 n.6 20162016-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000600003es10.4067/S0034-98872016000600003
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Biomarkers Environmental Exposure Kidney Failure Chronic Lead
spellingShingle	Biomarkers Environmental Exposure Kidney Failure Chronic Lead Cabrera,Walter E Behets,Geert Lamberts,Ludwig D'Haese,Patrick Plomo y nefropatía: Biomarcadores urinarios en la detección de daño renal precoz
description	The role of lead (Pb) as an environmental cause of nephropathy is difficult to ascertain due to the difficulty to determine clinically its exposure. Aim: To assess lead levels and renal function in a group of males working in mechanical workshops. Material and Methods: Blood and urine samples were obtained from 100 mechanical workshop workers aged 38 ± 16 years and 95 non-exposed office clerks aged 37 ± 17 years. Blood lead and creatinine levels were determined. In exposed workers, urinary excretion of intestinal alkaline phosphatases (IAP) and N-acetyl-glucosaminidase (NAG) were measured as early markers of renal failure. Results: Blood lead levels were 66.4 ± 43 and 33.6 ± 18 µg/L among mechanical workshop workers and non-exposed controls, respectively, p < 0.01. The figures for serum creatinine were 0.9 ± 0.1 and 0.9 ± 0.1 respectively, p = NS. Among exposed workers urinary excretion of IAP was 0.47 ± 0.6 U/L and of NAG, 0.92 ± 1.1 U/L. There was a positive correlation between blood lead levels and NAG excretion (r = 0.284) and IAP excretion (r = 0.346). Conclusions: Exposed workers had higher blood lead levels and there was a weak positive association between these levels and the urinary excretion of NAG and IAP.
author	Cabrera,Walter E Behets,Geert Lamberts,Ludwig D'Haese,Patrick
author_facet	Cabrera,Walter E Behets,Geert Lamberts,Ludwig D'Haese,Patrick
author_sort	Cabrera,Walter E
title	Plomo y nefropatía: Biomarcadores urinarios en la detección de daño renal precoz
title_short	Plomo y nefropatía: Biomarcadores urinarios en la detección de daño renal precoz
title_full	Plomo y nefropatía: Biomarcadores urinarios en la detección de daño renal precoz
title_fullStr	Plomo y nefropatía: Biomarcadores urinarios en la detección de daño renal precoz
title_full_unstemmed	Plomo y nefropatía: Biomarcadores urinarios en la detección de daño renal precoz
title_sort	plomo y nefropatía: biomarcadores urinarios en la detección de daño renal precoz
publisher	Sociedad Médica de Santiago
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000600003
work_keys_str_mv	AT cabrerawaltere plomoynefropatiabiomarcadoresurinariosenladetecciondedanorenalprecoz AT behetsgeert plomoynefropatiabiomarcadoresurinariosenladetecciondedanorenalprecoz AT lambertsludwig plomoynefropatiabiomarcadoresurinariosenladetecciondedanorenalprecoz AT dhaesepatrick plomoynefropatiabiomarcadoresurinariosenladetecciondedanorenalprecoz
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Plomo y nefropatía: Biomarcadores urinarios en la detección de daño renal precoz

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