Desafíos en el diagnóstico de enfermedad de Creutzfeldt-Jakob: Caso clínico

Creutzfeldt-Jakob disease has a higher incidence in Chile than in other countries. The post mortem pathological characterization of brain tissue is necessary to reach a definitive diagnosis. We report a 73 years old man with a history compatible with of a rapidly progressive dementia, in which the f...

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Autores principales:	Ramírez,Marcos, Gallardo,Andrés, Vidal,Aarón, Cornejo,Sebastián, Ramírez,Darío, Medinas,Danilo, Bustamante,Gonzalo, Pasquali,Renzo, Hetz,Claudio
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2016
Materias:	Biomarkers Creutzfeld-Jacob Syndrome Electroencephalography Status Epilepticus
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000600016
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spelling	oai:scielo:S0034-988720160006000162016-10-03Desafíos en el diagnóstico de enfermedad de Creutzfeldt-Jakob: Caso clínicoRamírez,MarcosGallardo,AndrésVidal,AarónCornejo,SebastiánRamírez,DaríoMedinas,DaniloBustamante,GonzaloPasquali,RenzoHetz,Claudio Biomarkers Creutzfeld-Jacob Syndrome Electroencephalography Status Epilepticus Creutzfeldt-Jakob disease has a higher incidence in Chile than in other countries. The post mortem pathological characterization of brain tissue is necessary to reach a definitive diagnosis. We report a 73 years old man with a history compatible with of a rapidly progressive dementia, in which the first electroencephalographic study showed a pattern consistent with non-convulsive status epilepticus. Besides discarding this diagnosis, it was necessary to rule out other causes of rapidly progressive dementia such as Hashimoto encephalopathy. Finally, the sustained clinical deterioration with no response to anticonvulsants and corticosteroids, the imaging studies, a serial electroencephalographic monitoring study and the detection of 14-3-3 protein in cerebrospinal fluid were the keys to achieve the diagnosis of the disease.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.144 n.6 20162016-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000600016es10.4067/S0034-98872016000600016
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Biomarkers Creutzfeld-Jacob Syndrome Electroencephalography Status Epilepticus
spellingShingle	Biomarkers Creutzfeld-Jacob Syndrome Electroencephalography Status Epilepticus Ramírez,Marcos Gallardo,Andrés Vidal,Aarón Cornejo,Sebastián Ramírez,Darío Medinas,Danilo Bustamante,Gonzalo Pasquali,Renzo Hetz,Claudio Desafíos en el diagnóstico de enfermedad de Creutzfeldt-Jakob: Caso clínico
description	Creutzfeldt-Jakob disease has a higher incidence in Chile than in other countries. The post mortem pathological characterization of brain tissue is necessary to reach a definitive diagnosis. We report a 73 years old man with a history compatible with of a rapidly progressive dementia, in which the first electroencephalographic study showed a pattern consistent with non-convulsive status epilepticus. Besides discarding this diagnosis, it was necessary to rule out other causes of rapidly progressive dementia such as Hashimoto encephalopathy. Finally, the sustained clinical deterioration with no response to anticonvulsants and corticosteroids, the imaging studies, a serial electroencephalographic monitoring study and the detection of 14-3-3 protein in cerebrospinal fluid were the keys to achieve the diagnosis of the disease.
author	Ramírez,Marcos Gallardo,Andrés Vidal,Aarón Cornejo,Sebastián Ramírez,Darío Medinas,Danilo Bustamante,Gonzalo Pasquali,Renzo Hetz,Claudio
author_facet	Ramírez,Marcos Gallardo,Andrés Vidal,Aarón Cornejo,Sebastián Ramírez,Darío Medinas,Danilo Bustamante,Gonzalo Pasquali,Renzo Hetz,Claudio
author_sort	Ramírez,Marcos
title	Desafíos en el diagnóstico de enfermedad de Creutzfeldt-Jakob: Caso clínico
title_short	Desafíos en el diagnóstico de enfermedad de Creutzfeldt-Jakob: Caso clínico
title_full	Desafíos en el diagnóstico de enfermedad de Creutzfeldt-Jakob: Caso clínico
title_fullStr	Desafíos en el diagnóstico de enfermedad de Creutzfeldt-Jakob: Caso clínico
title_full_unstemmed	Desafíos en el diagnóstico de enfermedad de Creutzfeldt-Jakob: Caso clínico
title_sort	desafíos en el diagnóstico de enfermedad de creutzfeldt-jakob: caso clínico
publisher	Sociedad Médica de Santiago
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000600016
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Desafíos en el diagnóstico de enfermedad de Creutzfeldt-Jakob: Caso clínico

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