Ergotismo por uso simultáneo de ergotamínico y terapia antirretroviral: Report of one case

High activity antiretroviral therapy may exacerbate the activity of ergot alkaloids due to an inhibition of cytochrome P450. We report a 57 years old female with AIDS treated with lamivudine, zidovudine, atazanavir, ritonavir and cotrimoxazole presenting with ischemic signs in the four limbs. There...

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Autores principales: Cifuentes M,Daniel, Blanco L,Sergio, Ramírez F,Camila
Lenguaje:Spanish / Castilian
Publicado: Sociedad Médica de Santiago 2016
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Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000600017
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spelling oai:scielo:S0034-988720160006000172016-10-03Ergotismo por uso simultáneo de ergotamínico y terapia antirretroviral: Report of one caseCifuentes M,DanielBlanco L,SergioRamírez F,Camila Acquired Immunodeficiency Syndrome Ergotism Ischemia High activity antiretroviral therapy may exacerbate the activity of ergot alkaloids due to an inhibition of cytochrome P450. We report a 57 years old female with AIDS treated with lamivudine, zidovudine, atazanavir, ritonavir and cotrimoxazole presenting with ischemic signs in the four limbs. There was acrocyanosis and weak radial and ulnar pulses. A family member referred that the patient used ergot alkaloids for headaches. An ergotism due to the simultaneous use of ergot alkaloids and antiretroviral therapy was suspected. The latter was discontinued and intravenous nitroglycerin, nifedipine and pentoxifyline were started with good results.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.144 n.6 20162016-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000600017es10.4067/S0034-98872016000600017
institution Scielo Chile
collection Scielo Chile
language Spanish / Castilian
topic Acquired Immunodeficiency Syndrome
Ergotism
Ischemia
spellingShingle Acquired Immunodeficiency Syndrome
Ergotism
Ischemia
Cifuentes M,Daniel
Blanco L,Sergio
Ramírez F,Camila
Ergotismo por uso simultáneo de ergotamínico y terapia antirretroviral: Report of one case
description High activity antiretroviral therapy may exacerbate the activity of ergot alkaloids due to an inhibition of cytochrome P450. We report a 57 years old female with AIDS treated with lamivudine, zidovudine, atazanavir, ritonavir and cotrimoxazole presenting with ischemic signs in the four limbs. There was acrocyanosis and weak radial and ulnar pulses. A family member referred that the patient used ergot alkaloids for headaches. An ergotism due to the simultaneous use of ergot alkaloids and antiretroviral therapy was suspected. The latter was discontinued and intravenous nitroglycerin, nifedipine and pentoxifyline were started with good results.
author Cifuentes M,Daniel
Blanco L,Sergio
Ramírez F,Camila
author_facet Cifuentes M,Daniel
Blanco L,Sergio
Ramírez F,Camila
author_sort Cifuentes M,Daniel
title Ergotismo por uso simultáneo de ergotamínico y terapia antirretroviral: Report of one case
title_short Ergotismo por uso simultáneo de ergotamínico y terapia antirretroviral: Report of one case
title_full Ergotismo por uso simultáneo de ergotamínico y terapia antirretroviral: Report of one case
title_fullStr Ergotismo por uso simultáneo de ergotamínico y terapia antirretroviral: Report of one case
title_full_unstemmed Ergotismo por uso simultáneo de ergotamínico y terapia antirretroviral: Report of one case
title_sort ergotismo por uso simultáneo de ergotamínico y terapia antirretroviral: report of one case
publisher Sociedad Médica de Santiago
publishDate 2016
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000600017
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AT blancolsergio ergotismoporusosimultaneodeergotaminicoyterapiaantirretroviralreportofonecase
AT ramirezfcamila ergotismoporusosimultaneodeergotaminicoyterapiaantirretroviralreportofonecase
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