Función renal al fallecimiento según causa de muerte en trasplantados renales

Background: Death with a functioning kidney graft is now the leading cause of graft loss after renal transplantation. Aim: To determine if renal function at the last outpatient visit before the recipients death was different according to the following causes of death: infections, cardiovascular dis...

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Autores principales:	Huidobro E,Juan Pablo, Vega,Jorge
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2016
Materias:	Cancer Infection Cardiovascular Diseases Kidney Transplantation Mortality
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000700005
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spelling	oai:scielo:S0034-988720160007000052016-10-03Función renal al fallecimiento según causa de muerte en trasplantados renalesHuidobro E,Juan PabloVega,Jorge Cancer Infection Cardiovascular Diseases Kidney Transplantation Mortality Background: Death with a functioning kidney graft is now the leading cause of graft loss after renal transplantation. Aim: To determine if renal function at the last outpatient visit before the recipients death was different according to the following causes of death: infections, cardiovascular diseases, gastrointestinal disorders or cancer. Patients and Methods: Retrospective cooperative cohort study conducted in two kidney transplant centers. All patients who received a kidney graft in the last 32 years were included. During that lapse, 431 kidney transplants were performed. Among them, 85 patients died with a functioning graft and were classified due to their cause of death. Glomerular filtration rate (eGFR) was estimated with the Modification of Diet in Renal Disease formula. Declining renal function was defined as a > 20% decline in eGFR during the last 6 months prior to the last outpatient visit. Results: Eighty four patients were included in the analysis. Of these, 28.2% died of cardiovascular causes, 35.3% of infectious diseases, 15.3% of cancer and 20% of digestive diseases. Patients dying from cancer had a significantly higher eGFR prior to death than those who died from cardiovascular causes, infectious and digestive diseases (p < 0.01). Declining renal function occurred in 34.8% of deaths from cardiovascular causes, 39.3% from infectious diseases, 16.7% from cancer and 40% from digestive diseases. There were no significant differences between groups. Conclusions: Kidney graft recipients who die with a functioning graft have better renal function prior to their death when it is due to cancer than when it originates from infectious, cardiovascular or digestive diseases. Declining renal function is similar in the four groups of death causes.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.144 n.7 20162016-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000700005es10.4067/S0034-98872016000700005
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Cancer Infection Cardiovascular Diseases Kidney Transplantation Mortality
spellingShingle	Cancer Infection Cardiovascular Diseases Kidney Transplantation Mortality Huidobro E,Juan Pablo Vega,Jorge Función renal al fallecimiento según causa de muerte en trasplantados renales
description	Background: Death with a functioning kidney graft is now the leading cause of graft loss after renal transplantation. Aim: To determine if renal function at the last outpatient visit before the recipients death was different according to the following causes of death: infections, cardiovascular diseases, gastrointestinal disorders or cancer. Patients and Methods: Retrospective cooperative cohort study conducted in two kidney transplant centers. All patients who received a kidney graft in the last 32 years were included. During that lapse, 431 kidney transplants were performed. Among them, 85 patients died with a functioning graft and were classified due to their cause of death. Glomerular filtration rate (eGFR) was estimated with the Modification of Diet in Renal Disease formula. Declining renal function was defined as a > 20% decline in eGFR during the last 6 months prior to the last outpatient visit. Results: Eighty four patients were included in the analysis. Of these, 28.2% died of cardiovascular causes, 35.3% of infectious diseases, 15.3% of cancer and 20% of digestive diseases. Patients dying from cancer had a significantly higher eGFR prior to death than those who died from cardiovascular causes, infectious and digestive diseases (p < 0.01). Declining renal function occurred in 34.8% of deaths from cardiovascular causes, 39.3% from infectious diseases, 16.7% from cancer and 40% from digestive diseases. There were no significant differences between groups. Conclusions: Kidney graft recipients who die with a functioning graft have better renal function prior to their death when it is due to cancer than when it originates from infectious, cardiovascular or digestive diseases. Declining renal function is similar in the four groups of death causes.
author	Huidobro E,Juan Pablo Vega,Jorge
author_facet	Huidobro E,Juan Pablo Vega,Jorge
author_sort	Huidobro E,Juan Pablo
title	Función renal al fallecimiento según causa de muerte en trasplantados renales
title_short	Función renal al fallecimiento según causa de muerte en trasplantados renales
title_full	Función renal al fallecimiento según causa de muerte en trasplantados renales
title_fullStr	Función renal al fallecimiento según causa de muerte en trasplantados renales
title_full_unstemmed	Función renal al fallecimiento según causa de muerte en trasplantados renales
title_sort	función renal al fallecimiento según causa de muerte en trasplantados renales
publisher	Sociedad Médica de Santiago
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000700005
work_keys_str_mv	AT huidobroejuanpablo funcionrenalalfallecimientoseguncausademuerteentrasplantadosrenales AT vegajorge funcionrenalalfallecimientoseguncausademuerteentrasplantadosrenales
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Función renal al fallecimiento según causa de muerte en trasplantados renales

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