Rol de la microbiota gastrointestinal en la regulación de la respuesta inmune

The gastrointestinal tract hosts around 10(14) bacterial microorganisms, in a constantly growing density from the stomach to the distal colon. This microbiota is composed by more than 500 species of bacteria, which are quickly acquired after birth, fairly stable during the hosts life, and essential...

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Autores principales:	Alarcón,Pedro, González,Margarita, Castro,Érica
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2016
Materias:	Intestines Immunity Microbiota Probiotics
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000700013
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spelling	oai:scielo:S0034-988720160007000132016-10-03Rol de la microbiota gastrointestinal en la regulación de la respuesta inmuneAlarcón,PedroGonzález,MargaritaCastro,Érica Intestines Immunity Microbiota Probiotics The gastrointestinal tract hosts around 10(14) bacterial microorganisms, in a constantly growing density from the stomach to the distal colon. This microbiota is composed by more than 500 species of bacteria, which are quickly acquired after birth, fairly stable during the hosts life, and essential for human homeostasis. These bacteria have important functions, such as stimulating the immune system, protecting the host from invading bacteria and viruses, and improving digestion, especially of complex carbohydrates. Also, the gut microbiota interacts directly with the immune system. However, the interaction of the intestinal epithelium and its microbiota with the immune system has yet to be fully understood. Secretory immunoglobulin A, produced by the plasma cells in Peyers patches and in the lamina propria, maintains non-invasive commensal bacteria and neutralize invasive pathogens. Dendritic cells migrate from the lamina propria of the secondary lymphoid organs to regulate gut immunity. They also have a key role maintaining luminal IgA and inducing the growth of regulatory T cells. Dendritic cells supervise the gut microenvironment too, keeping an immunological equilibrium and tolerance. The importance of the gut microbiota in regulating the immune system lies mostly in the homeostasis-or positive equilibrium. Thus, many diseases are a consequence of poor interactions or a loss of this equilibrium.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.144 n.7 20162016-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000700013es10.4067/S0034-98872016000700013
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Intestines Immunity Microbiota Probiotics
spellingShingle	Intestines Immunity Microbiota Probiotics Alarcón,Pedro González,Margarita Castro,Érica Rol de la microbiota gastrointestinal en la regulación de la respuesta inmune
description	The gastrointestinal tract hosts around 10(14) bacterial microorganisms, in a constantly growing density from the stomach to the distal colon. This microbiota is composed by more than 500 species of bacteria, which are quickly acquired after birth, fairly stable during the hosts life, and essential for human homeostasis. These bacteria have important functions, such as stimulating the immune system, protecting the host from invading bacteria and viruses, and improving digestion, especially of complex carbohydrates. Also, the gut microbiota interacts directly with the immune system. However, the interaction of the intestinal epithelium and its microbiota with the immune system has yet to be fully understood. Secretory immunoglobulin A, produced by the plasma cells in Peyers patches and in the lamina propria, maintains non-invasive commensal bacteria and neutralize invasive pathogens. Dendritic cells migrate from the lamina propria of the secondary lymphoid organs to regulate gut immunity. They also have a key role maintaining luminal IgA and inducing the growth of regulatory T cells. Dendritic cells supervise the gut microenvironment too, keeping an immunological equilibrium and tolerance. The importance of the gut microbiota in regulating the immune system lies mostly in the homeostasis-or positive equilibrium. Thus, many diseases are a consequence of poor interactions or a loss of this equilibrium.
author	Alarcón,Pedro González,Margarita Castro,Érica
author_facet	Alarcón,Pedro González,Margarita Castro,Érica
author_sort	Alarcón,Pedro
title	Rol de la microbiota gastrointestinal en la regulación de la respuesta inmune
title_short	Rol de la microbiota gastrointestinal en la regulación de la respuesta inmune
title_full	Rol de la microbiota gastrointestinal en la regulación de la respuesta inmune
title_fullStr	Rol de la microbiota gastrointestinal en la regulación de la respuesta inmune
title_full_unstemmed	Rol de la microbiota gastrointestinal en la regulación de la respuesta inmune
title_sort	rol de la microbiota gastrointestinal en la regulación de la respuesta inmune
publisher	Sociedad Médica de Santiago
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000700013
work_keys_str_mv	AT alarconpedro roldelamicrobiotagastrointestinalenlaregulaciondelarespuestainmune AT gonzalezmargarita roldelamicrobiotagastrointestinalenlaregulaciondelarespuestainmune AT castroerica roldelamicrobiotagastrointestinalenlaregulaciondelarespuestainmune
_version_	1718436895210340352

Rol de la microbiota gastrointestinal en la regulación de la respuesta inmune

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