Fisuras labio-palatinas y fortificación de la harina con ácido fólico en Chile: An exploratory study

Background: The effect of food fortification with folic acid on the incidence of lip-palate fissures (FLP) is under discussion. Aim: To calculate the rate of hospital discharges due to cleft lip and palate (CLP) and explore whether they decreased after the start of folic acid fortification in Chile....

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Autores principales:	Paulos,Angélica, Pino,Paulina, Cavada,Gabriel, Lagos,Carolina, Broussain,Valentina, Hasbún,Andrea
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2016
Materias:	Cleft Lip Cleft Palate Folic Acid Food Fortified
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000800008
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spelling	oai:scielo:S0034-988720160008000082016-12-21Fisuras labio-palatinas y fortificación de la harina con ácido fólico en Chile: An exploratory studyPaulos,AngélicaPino,PaulinaCavada,GabrielLagos,CarolinaBroussain,ValentinaHasbún,Andrea Cleft Lip Cleft Palate Folic Acid Food Fortified Background: The effect of food fortification with folic acid on the incidence of lip-palate fissures (FLP) is under discussion. Aim: To calculate the rate of hospital discharges due to cleft lip and palate (CLP) and explore whether they decreased after the start of folic acid fortification in Chile. Material and Methods: The hospital discharge databases published by the Chilean Ministry of Health were analyzed. The trends of discharge rates due to CLP of children of less than one year of life (ICD-10 Q350-379 code) and live births (lb) were calculated from 1986 to 2012. Variables such as incidence of rubella, poverty rate, obesity in pregnant women, and percentage of women who smoked or drank alcohol in the last month were included. The relative risk (RR) of CLP pre-fortification (1986-1999) and post-fortification (2000-2010) was calculated. Mixed and Prais-Winsten models were used to adjust other variables. Results: The hospital discharge rate due to CLP decreased from 1.88 x 1,000 lb during 1986-1996 to 1.68 x 1,000 lb (RR = 1.09 (95% CI 1.05-1.14, p < 0.001). Prais-Winsten and Mixed models, determined that folic acid fortification is the variable explaining this decrease. During 2004-2011, hospital discharge rates for cleft lip decreased but there was an increase in the figures for cleft lip and palate. Conclusions: The 9% decrease in hospital discharge rates for CLP is concomitant with wheat folic acid fortification.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.144 n.8 20162016-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000800008es10.4067/S0034-98872016000800008
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Cleft Lip Cleft Palate Folic Acid Food Fortified
spellingShingle	Cleft Lip Cleft Palate Folic Acid Food Fortified Paulos,Angélica Pino,Paulina Cavada,Gabriel Lagos,Carolina Broussain,Valentina Hasbún,Andrea Fisuras labio-palatinas y fortificación de la harina con ácido fólico en Chile: An exploratory study
description	Background: The effect of food fortification with folic acid on the incidence of lip-palate fissures (FLP) is under discussion. Aim: To calculate the rate of hospital discharges due to cleft lip and palate (CLP) and explore whether they decreased after the start of folic acid fortification in Chile. Material and Methods: The hospital discharge databases published by the Chilean Ministry of Health were analyzed. The trends of discharge rates due to CLP of children of less than one year of life (ICD-10 Q350-379 code) and live births (lb) were calculated from 1986 to 2012. Variables such as incidence of rubella, poverty rate, obesity in pregnant women, and percentage of women who smoked or drank alcohol in the last month were included. The relative risk (RR) of CLP pre-fortification (1986-1999) and post-fortification (2000-2010) was calculated. Mixed and Prais-Winsten models were used to adjust other variables. Results: The hospital discharge rate due to CLP decreased from 1.88 x 1,000 lb during 1986-1996 to 1.68 x 1,000 lb (RR = 1.09 (95% CI 1.05-1.14, p < 0.001). Prais-Winsten and Mixed models, determined that folic acid fortification is the variable explaining this decrease. During 2004-2011, hospital discharge rates for cleft lip decreased but there was an increase in the figures for cleft lip and palate. Conclusions: The 9% decrease in hospital discharge rates for CLP is concomitant with wheat folic acid fortification.
author	Paulos,Angélica Pino,Paulina Cavada,Gabriel Lagos,Carolina Broussain,Valentina Hasbún,Andrea
author_facet	Paulos,Angélica Pino,Paulina Cavada,Gabriel Lagos,Carolina Broussain,Valentina Hasbún,Andrea
author_sort	Paulos,Angélica
title	Fisuras labio-palatinas y fortificación de la harina con ácido fólico en Chile: An exploratory study
title_short	Fisuras labio-palatinas y fortificación de la harina con ácido fólico en Chile: An exploratory study
title_full	Fisuras labio-palatinas y fortificación de la harina con ácido fólico en Chile: An exploratory study
title_fullStr	Fisuras labio-palatinas y fortificación de la harina con ácido fólico en Chile: An exploratory study
title_full_unstemmed	Fisuras labio-palatinas y fortificación de la harina con ácido fólico en Chile: An exploratory study
title_sort	fisuras labio-palatinas y fortificación de la harina con ácido fólico en chile: an exploratory study
publisher	Sociedad Médica de Santiago
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000800008
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Fisuras labio-palatinas y fortificación de la harina con ácido fólico en Chile: An exploratory study

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