Salud ósea en pacientes sometidos a trasplante de precursores hematopoyéticos: un nuevo problema a considerar

Background: Patients undergoing hematopoietic cell transplantation (HCT) are at increased risk of developing osteoporosis. Aim: To determine the frequency and severity of Vitamin D deficiency, secondary hyperparathyroidism and low bone mass in patients undergoing HCT. Patients and Methods: Analysis...

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Auteurs principaux:	Florenzano,Pablo, Ernst,Daniel, Lustig,Nicole, Rojas,Patricio, Ramírez,Pablo, Campusano,Claudia
Langue:	Spanish / Castilian
Publié:	Sociedad Médica de Santiago 2016
Sujets:	Hematopoietic Stem Cell Transplantation Hyperparathyroidism Secondary Osteoporosis Vitamin D
Accès en ligne:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000900004
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spelling	oai:scielo:S0034-988720160009000042016-12-23Salud ósea en pacientes sometidos a trasplante de precursores hematopoyéticos: un nuevo problema a considerarFlorenzano,PabloErnst,DanielLustig,NicoleRojas,PatricioRamírez,PabloCampusano,Claudia Hematopoietic Stem Cell Transplantation Hyperparathyroidism Secondary Osteoporosis Vitamin D Background: Patients undergoing hematopoietic cell transplantation (HCT) are at increased risk of developing osteoporosis. Aim: To determine the frequency and severity of Vitamin D deficiency, secondary hyperparathyroidism and low bone mass in patients undergoing HCT. Patients and Methods: Analysis of the database of patients undergoing HCT in our institution in the 2010-2015 period. We searched for patients with measurements of 25-OH vitamin D (25OHD), parathyroid hormone (PTH) and bone densitometry by double beam X ray absorptiometry (DXA) prior and up to one year after HCT. Results: Ninety patients were included, 53 were evaluated prior to HCT and 37 after HCT. They represent 73% of all patients undergoing HCT in the period. Median 25OHD was 12 ng/ml (range 4-41.4). Ninety seven percent of patients had levels considered insufficient and 85% compatible with deficiency. Median PTH was 60.5 pg/ml (range 21-186). Forty five percent of patients had secondary hyperparathyroidism. DXA was performed in 65 patients (prior to HCT in 54 and after HCT in 11). Of these, 11% had had a low bone mineral density. Conclusions: Patients undergoing HCT have a high risk of vitamin D deficiency, secondary hyperparathyroidism and low bone mineral density.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.144 n.9 20162016-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000900004es10.4067/S0034-98872016000900004
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Hematopoietic Stem Cell Transplantation Hyperparathyroidism Secondary Osteoporosis Vitamin D
spellingShingle	Hematopoietic Stem Cell Transplantation Hyperparathyroidism Secondary Osteoporosis Vitamin D Florenzano,Pablo Ernst,Daniel Lustig,Nicole Rojas,Patricio Ramírez,Pablo Campusano,Claudia Salud ósea en pacientes sometidos a trasplante de precursores hematopoyéticos: un nuevo problema a considerar
description	Background: Patients undergoing hematopoietic cell transplantation (HCT) are at increased risk of developing osteoporosis. Aim: To determine the frequency and severity of Vitamin D deficiency, secondary hyperparathyroidism and low bone mass in patients undergoing HCT. Patients and Methods: Analysis of the database of patients undergoing HCT in our institution in the 2010-2015 period. We searched for patients with measurements of 25-OH vitamin D (25OHD), parathyroid hormone (PTH) and bone densitometry by double beam X ray absorptiometry (DXA) prior and up to one year after HCT. Results: Ninety patients were included, 53 were evaluated prior to HCT and 37 after HCT. They represent 73% of all patients undergoing HCT in the period. Median 25OHD was 12 ng/ml (range 4-41.4). Ninety seven percent of patients had levels considered insufficient and 85% compatible with deficiency. Median PTH was 60.5 pg/ml (range 21-186). Forty five percent of patients had secondary hyperparathyroidism. DXA was performed in 65 patients (prior to HCT in 54 and after HCT in 11). Of these, 11% had had a low bone mineral density. Conclusions: Patients undergoing HCT have a high risk of vitamin D deficiency, secondary hyperparathyroidism and low bone mineral density.
author	Florenzano,Pablo Ernst,Daniel Lustig,Nicole Rojas,Patricio Ramírez,Pablo Campusano,Claudia
author_facet	Florenzano,Pablo Ernst,Daniel Lustig,Nicole Rojas,Patricio Ramírez,Pablo Campusano,Claudia
author_sort	Florenzano,Pablo
title	Salud ósea en pacientes sometidos a trasplante de precursores hematopoyéticos: un nuevo problema a considerar
title_short	Salud ósea en pacientes sometidos a trasplante de precursores hematopoyéticos: un nuevo problema a considerar
title_full	Salud ósea en pacientes sometidos a trasplante de precursores hematopoyéticos: un nuevo problema a considerar
title_fullStr	Salud ósea en pacientes sometidos a trasplante de precursores hematopoyéticos: un nuevo problema a considerar
title_full_unstemmed	Salud ósea en pacientes sometidos a trasplante de precursores hematopoyéticos: un nuevo problema a considerar
title_sort	salud ósea en pacientes sometidos a trasplante de precursores hematopoyéticos: un nuevo problema a considerar
publisher	Sociedad Médica de Santiago
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000900004
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Salud ósea en pacientes sometidos a trasplante de precursores hematopoyéticos: un nuevo problema a considerar

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