Salud ósea en pacientes sometidos a trasplante de precursores hematopoyéticos: un nuevo problema a considerar
Background: Patients undergoing hematopoietic cell transplantation (HCT) are at increased risk of developing osteoporosis. Aim: To determine the frequency and severity of Vitamin D deficiency, secondary hyperparathyroidism and low bone mass in patients undergoing HCT. Patients and Methods: Analysis...
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Sociedad Médica de Santiago
2016
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oai:scielo:S0034-988720160009000042016-12-23Salud ósea en pacientes sometidos a trasplante de precursores hematopoyéticos: un nuevo problema a considerarFlorenzano,PabloErnst,DanielLustig,NicoleRojas,PatricioRamírez,PabloCampusano,Claudia Hematopoietic Stem Cell Transplantation Hyperparathyroidism Secondary Osteoporosis Vitamin D Background: Patients undergoing hematopoietic cell transplantation (HCT) are at increased risk of developing osteoporosis. Aim: To determine the frequency and severity of Vitamin D deficiency, secondary hyperparathyroidism and low bone mass in patients undergoing HCT. Patients and Methods: Analysis of the database of patients undergoing HCT in our institution in the 2010-2015 period. We searched for patients with measurements of 25-OH vitamin D (25OHD), parathyroid hormone (PTH) and bone densitometry by double beam X ray absorptiometry (DXA) prior and up to one year after HCT. Results: Ninety patients were included, 53 were evaluated prior to HCT and 37 after HCT. They represent 73% of all patients undergoing HCT in the period. Median 25OHD was 12 ng/ml (range 4-41.4). Ninety seven percent of patients had levels considered insufficient and 85% compatible with deficiency. Median PTH was 60.5 pg/ml (range 21-186). Forty five percent of patients had secondary hyperparathyroidism. DXA was performed in 65 patients (prior to HCT in 54 and after HCT in 11). Of these, 11% had had a low bone mineral density. Conclusions: Patients undergoing HCT have a high risk of vitamin D deficiency, secondary hyperparathyroidism and low bone mineral density.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.144 n.9 20162016-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000900004es10.4067/S0034-98872016000900004 |
institution |
Scielo Chile |
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Scielo Chile |
language |
Spanish / Castilian |
topic |
Hematopoietic Stem Cell Transplantation Hyperparathyroidism Secondary Osteoporosis Vitamin D |
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Hematopoietic Stem Cell Transplantation Hyperparathyroidism Secondary Osteoporosis Vitamin D Florenzano,Pablo Ernst,Daniel Lustig,Nicole Rojas,Patricio Ramírez,Pablo Campusano,Claudia Salud ósea en pacientes sometidos a trasplante de precursores hematopoyéticos: un nuevo problema a considerar |
description |
Background: Patients undergoing hematopoietic cell transplantation (HCT) are at increased risk of developing osteoporosis. Aim: To determine the frequency and severity of Vitamin D deficiency, secondary hyperparathyroidism and low bone mass in patients undergoing HCT. Patients and Methods: Analysis of the database of patients undergoing HCT in our institution in the 2010-2015 period. We searched for patients with measurements of 25-OH vitamin D (25OHD), parathyroid hormone (PTH) and bone densitometry by double beam X ray absorptiometry (DXA) prior and up to one year after HCT. Results: Ninety patients were included, 53 were evaluated prior to HCT and 37 after HCT. They represent 73% of all patients undergoing HCT in the period. Median 25OHD was 12 ng/ml (range 4-41.4). Ninety seven percent of patients had levels considered insufficient and 85% compatible with deficiency. Median PTH was 60.5 pg/ml (range 21-186). Forty five percent of patients had secondary hyperparathyroidism. DXA was performed in 65 patients (prior to HCT in 54 and after HCT in 11). Of these, 11% had had a low bone mineral density. Conclusions: Patients undergoing HCT have a high risk of vitamin D deficiency, secondary hyperparathyroidism and low bone mineral density. |
author |
Florenzano,Pablo Ernst,Daniel Lustig,Nicole Rojas,Patricio Ramírez,Pablo Campusano,Claudia |
author_facet |
Florenzano,Pablo Ernst,Daniel Lustig,Nicole Rojas,Patricio Ramírez,Pablo Campusano,Claudia |
author_sort |
Florenzano,Pablo |
title |
Salud ósea en pacientes sometidos a trasplante de precursores hematopoyéticos: un nuevo problema a considerar |
title_short |
Salud ósea en pacientes sometidos a trasplante de precursores hematopoyéticos: un nuevo problema a considerar |
title_full |
Salud ósea en pacientes sometidos a trasplante de precursores hematopoyéticos: un nuevo problema a considerar |
title_fullStr |
Salud ósea en pacientes sometidos a trasplante de precursores hematopoyéticos: un nuevo problema a considerar |
title_full_unstemmed |
Salud ósea en pacientes sometidos a trasplante de precursores hematopoyéticos: un nuevo problema a considerar |
title_sort |
salud ósea en pacientes sometidos a trasplante de precursores hematopoyéticos: un nuevo problema a considerar |
publisher |
Sociedad Médica de Santiago |
publishDate |
2016 |
url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000900004 |
work_keys_str_mv |
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