Aumento de la mortalidad infantil en niños con síndrome de Down: Chile 1997-2013

Background: Down syndrome (DS) is associated with higher child mortality especially due to cardiac malformations. Aim: To describe the trend in Chilean infant mortality in DS in the period 1997-2013 as compared to the general population without DS. Material and Methods: Raw data on infant deaths wer...

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Autores principales:	Donoso,Enrique, Vera,Claudio
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2016
Materias:	Chile Down Syndrome Heart Defects Congenital Infant Mortality
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016001100009
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spelling	oai:scielo:S0034-988720160011000092017-01-25Aumento de la mortalidad infantil en niños con síndrome de Down: Chile 1997-2013Donoso,EnriqueVera,Claudio Chile Down Syndrome Heart Defects Congenital Infant Mortality Background: Down syndrome (DS) is associated with higher child mortality especially due to cardiac malformations. Aim: To describe the trend in Chilean infant mortality in DS in the period 1997-2013 as compared to the general population without DS. Material and Methods: Raw data on infant deaths were extracted from the yearbooks of vital statistics of the National Institute of Statistics. The mortality risk associated to DS, relative to population without DS was estimated. Results: There were 456 deaths in infants with DS during the study period (59 early neonatal deaths, 70 late neonatal deaths and 327 post-neonatal deaths). The trend in infant mortality rate in DS was ascending (r: 0.53, p = 0.03), with an average annual percentage change of 4.6% (95% confidence interval (CI) 0.4-9.0%; p < 0.01). Compared to the population without DS, the risk of early neonatal death was lower in DS (Odds ratio (OR) 0.14, 95% CI 0.11-0.19; p < 0.01) whereas the risk of post-neonatal death was higher (OR 4.74, 95% CI 3.85-5.85; p < 0.01). Conclusions: Infant mortality in Down syndrome has an increasing trend. We postulate that these children are not accessing timely cardiac surgery, the main therapeutic tool to reduce the death risk in the first year of life.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.144 n.11 20162016-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016001100009es10.4067/S0034-98872016001100009
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Chile Down Syndrome Heart Defects Congenital Infant Mortality
spellingShingle	Chile Down Syndrome Heart Defects Congenital Infant Mortality Donoso,Enrique Vera,Claudio Aumento de la mortalidad infantil en niños con síndrome de Down: Chile 1997-2013
description	Background: Down syndrome (DS) is associated with higher child mortality especially due to cardiac malformations. Aim: To describe the trend in Chilean infant mortality in DS in the period 1997-2013 as compared to the general population without DS. Material and Methods: Raw data on infant deaths were extracted from the yearbooks of vital statistics of the National Institute of Statistics. The mortality risk associated to DS, relative to population without DS was estimated. Results: There were 456 deaths in infants with DS during the study period (59 early neonatal deaths, 70 late neonatal deaths and 327 post-neonatal deaths). The trend in infant mortality rate in DS was ascending (r: 0.53, p = 0.03), with an average annual percentage change of 4.6% (95% confidence interval (CI) 0.4-9.0%; p < 0.01). Compared to the population without DS, the risk of early neonatal death was lower in DS (Odds ratio (OR) 0.14, 95% CI 0.11-0.19; p < 0.01) whereas the risk of post-neonatal death was higher (OR 4.74, 95% CI 3.85-5.85; p < 0.01). Conclusions: Infant mortality in Down syndrome has an increasing trend. We postulate that these children are not accessing timely cardiac surgery, the main therapeutic tool to reduce the death risk in the first year of life.
author	Donoso,Enrique Vera,Claudio
author_facet	Donoso,Enrique Vera,Claudio
author_sort	Donoso,Enrique
title	Aumento de la mortalidad infantil en niños con síndrome de Down: Chile 1997-2013
title_short	Aumento de la mortalidad infantil en niños con síndrome de Down: Chile 1997-2013
title_full	Aumento de la mortalidad infantil en niños con síndrome de Down: Chile 1997-2013
title_fullStr	Aumento de la mortalidad infantil en niños con síndrome de Down: Chile 1997-2013
title_full_unstemmed	Aumento de la mortalidad infantil en niños con síndrome de Down: Chile 1997-2013
title_sort	aumento de la mortalidad infantil en niños con síndrome de down: chile 1997-2013
publisher	Sociedad Médica de Santiago
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016001100009
work_keys_str_mv	AT donosoenrique aumentodelamortalidadinfantilenninosconsindromededownchile19972013 AT veraclaudio aumentodelamortalidadinfantilenninosconsindromededownchile19972013
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Aumento de la mortalidad infantil en niños con síndrome de Down: Chile 1997-2013

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