Participación de los virus respiratorios en la neumonía del adulto inmunocompetente adquirida en la comunidad

Background: Community-acquired pneumonia (CAP) is a relevant worldwide cause of morbidity and mortality in adult population, however its etiology is often not identified and therapy is empirical. Aim: To assess the etiology of CAP in immunocompetent adult hospitalized patients using conventional and...

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Autores principales:	Saldías Peñafiel,Fernando, Ortega Gutiérrez,Marcos, Fuentes López,Gino, Elola Aránguiz,José Manuel, Uribe Monasterio,Javier, Morales Soto,Arturo, Díaz Patiño,Orlando
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2016
Materias:	Molecular DiagnosticTechniques Pneumonia Viral
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016001200002
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spelling	oai:scielo:S0034-988720160012000022017-03-17Participación de los virus respiratorios en la neumonía del adulto inmunocompetente adquirida en la comunidadSaldías Peñafiel,FernandoOrtega Gutiérrez,MarcosFuentes López,GinoElola Aránguiz,José ManuelUribe Monasterio,JavierMorales Soto,ArturoDíaz Patiño,Orlando Molecular DiagnosticTechniques Pneumonia Pneumonia Viral Background: Community-acquired pneumonia (CAP) is a relevant worldwide cause of morbidity and mortality in adult population, however its etiology is often not identified and therapy is empirical. Aim: To assess the etiology of CAP in immunocompetent adult hospitalized patients using conventional and molecular diagnostic methods. Material and Methods: We prospectively studied 240 adult patients who were hospitalized for CAP to identify the microbial etiology. Sputum and blood cultures were obtained as well as serology testing for Mycoplasma pneumoniae and Chlamydophila pneumoniae, urinary antigen testing for Legionella pneumophila and Streptococcus pneumoniae, and a nasopharyngeal swab for the detection of sixteen respiratory viruses by reverse transcriptase polymerase chain reaction (RT-PCR). Results: In 100 patients (41.7%) a single respiratory pathogen was identified. In 17 (7.1%) cases, a mixed bacterial and viral infection was detected and no pathogen was identified in 123 cases (51%). The most commonly identified pathogens identified were: influenza virus (15.4%), parainfluenza virus (10.8%), rhinovirus (5%), Streptococcus pneumoniae (5%), respiratory syncytial virus (2.9%) and Mycoplasma pneumoniae (2.5%). Infectious agent detection by RT-PCR provided greater sensitivity than conventional techniques. Viral respiratory infections were more prevalent in older patients with comorbidities and high risk patients, according to the Fine index at hospital admission. The clinical severity and outcome were independent of the etiological agents detected. Conclusions: The use of molecular diagnostic techniques expanded the detection of respiratory viruses in immunocompetent adults hospitalized with CAP.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.144 n.12 20162016-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016001200002es10.4067/S0034-98872016001200002
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Molecular DiagnosticTechniques Pneumonia Pneumonia Viral
spellingShingle	Molecular DiagnosticTechniques Pneumonia Pneumonia Viral Saldías Peñafiel,Fernando Ortega Gutiérrez,Marcos Fuentes López,Gino Elola Aránguiz,José Manuel Uribe Monasterio,Javier Morales Soto,Arturo Díaz Patiño,Orlando Participación de los virus respiratorios en la neumonía del adulto inmunocompetente adquirida en la comunidad
description	Background: Community-acquired pneumonia (CAP) is a relevant worldwide cause of morbidity and mortality in adult population, however its etiology is often not identified and therapy is empirical. Aim: To assess the etiology of CAP in immunocompetent adult hospitalized patients using conventional and molecular diagnostic methods. Material and Methods: We prospectively studied 240 adult patients who were hospitalized for CAP to identify the microbial etiology. Sputum and blood cultures were obtained as well as serology testing for Mycoplasma pneumoniae and Chlamydophila pneumoniae, urinary antigen testing for Legionella pneumophila and Streptococcus pneumoniae, and a nasopharyngeal swab for the detection of sixteen respiratory viruses by reverse transcriptase polymerase chain reaction (RT-PCR). Results: In 100 patients (41.7%) a single respiratory pathogen was identified. In 17 (7.1%) cases, a mixed bacterial and viral infection was detected and no pathogen was identified in 123 cases (51%). The most commonly identified pathogens identified were: influenza virus (15.4%), parainfluenza virus (10.8%), rhinovirus (5%), Streptococcus pneumoniae (5%), respiratory syncytial virus (2.9%) and Mycoplasma pneumoniae (2.5%). Infectious agent detection by RT-PCR provided greater sensitivity than conventional techniques. Viral respiratory infections were more prevalent in older patients with comorbidities and high risk patients, according to the Fine index at hospital admission. The clinical severity and outcome were independent of the etiological agents detected. Conclusions: The use of molecular diagnostic techniques expanded the detection of respiratory viruses in immunocompetent adults hospitalized with CAP.
author	Saldías Peñafiel,Fernando Ortega Gutiérrez,Marcos Fuentes López,Gino Elola Aránguiz,José Manuel Uribe Monasterio,Javier Morales Soto,Arturo Díaz Patiño,Orlando
author_facet	Saldías Peñafiel,Fernando Ortega Gutiérrez,Marcos Fuentes López,Gino Elola Aránguiz,José Manuel Uribe Monasterio,Javier Morales Soto,Arturo Díaz Patiño,Orlando
author_sort	Saldías Peñafiel,Fernando
title	Participación de los virus respiratorios en la neumonía del adulto inmunocompetente adquirida en la comunidad
title_short	Participación de los virus respiratorios en la neumonía del adulto inmunocompetente adquirida en la comunidad
title_full	Participación de los virus respiratorios en la neumonía del adulto inmunocompetente adquirida en la comunidad
title_fullStr	Participación de los virus respiratorios en la neumonía del adulto inmunocompetente adquirida en la comunidad
title_full_unstemmed	Participación de los virus respiratorios en la neumonía del adulto inmunocompetente adquirida en la comunidad
title_sort	participación de los virus respiratorios en la neumonía del adulto inmunocompetente adquirida en la comunidad
publisher	Sociedad Médica de Santiago
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016001200002
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Participación de los virus respiratorios en la neumonía del adulto inmunocompetente adquirida en la comunidad

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