GRP78 levels, regional fat distribution and endometrial cáncer

Background: The association of obesity with endometrial cancer is supported by the presence of endoplasmic reticulum (ER) stress in the adipocyte. Glucose-regulated protein 78 (GRP78) is a marker for ER stress. This protein is a central regulator of ER stress due to its major anti-apoptotic role. It...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ciortea,Răzvan, Malutan,Andrei M, Angheluta,Lenuta M, Bucuri,Carmen E, Rada,Maria P, Mihu,Dan
Lenguaje:	English
Publicado:	Sociedad Médica de Santiago 2016
Materias:	Adipose Tissue Endometrial Neoplasms Obesity Endoplasmic Reticulum Stress
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016001200009
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0034-98872016001200009
record_format	dspace
spelling	oai:scielo:S0034-988720160012000092017-03-17GRP78 levels, regional fat distribution and endometrial cáncerCiortea,RăzvanMalutan,Andrei MAngheluta,Lenuta MBucuri,Carmen ERada,Maria PMihu,Dan Adipose Tissue Endometrial Neoplasms Obesity Endoplasmic Reticulum Stress Background: The association of obesity with endometrial cancer is supported by the presence of endoplasmic reticulum (ER) stress in the adipocyte. Glucose-regulated protein 78 (GRP78) is a marker for ER stress. This protein is a central regulator of ER stress due to its major anti-apoptotic role. It plays an important role in tumor development, progression and chemoresistance. Aim: To look for an association between android and gynoid obesity, plasma GRP78 levels and endometrial cancer. Material and methods: Forty four patients with endometrial cancer aged 72 ± 6 years and 44 healthy women aged 55 ± 9 years were studied. Android and gynoid fat distribution were determined by dual X-ray absorptiometry and plasma GRP78 levels were measured. Results: GRP78 plasma levels were significantly higher in patients with endometrial cancer as compared to the control group. Android fat distribution had a positive correlation with plasma GRP78 levels (p<0.01). Gynoid fat had a negative correlation with plasma GRP78 levels (p<0.01). Conclusions: GRP78 levels are associated with the distribution of adipose tissue and are higher in patients with endometrial cancer.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.144 n.12 20162016-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016001200009en10.4067/S0034-98872016001200009
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Adipose Tissue Endometrial Neoplasms Obesity Endoplasmic Reticulum Stress
spellingShingle	Adipose Tissue Endometrial Neoplasms Obesity Endoplasmic Reticulum Stress Ciortea,Răzvan Malutan,Andrei M Angheluta,Lenuta M Bucuri,Carmen E Rada,Maria P Mihu,Dan GRP78 levels, regional fat distribution and endometrial cáncer
description	Background: The association of obesity with endometrial cancer is supported by the presence of endoplasmic reticulum (ER) stress in the adipocyte. Glucose-regulated protein 78 (GRP78) is a marker for ER stress. This protein is a central regulator of ER stress due to its major anti-apoptotic role. It plays an important role in tumor development, progression and chemoresistance. Aim: To look for an association between android and gynoid obesity, plasma GRP78 levels and endometrial cancer. Material and methods: Forty four patients with endometrial cancer aged 72 ± 6 years and 44 healthy women aged 55 ± 9 years were studied. Android and gynoid fat distribution were determined by dual X-ray absorptiometry and plasma GRP78 levels were measured. Results: GRP78 plasma levels were significantly higher in patients with endometrial cancer as compared to the control group. Android fat distribution had a positive correlation with plasma GRP78 levels (p<0.01). Gynoid fat had a negative correlation with plasma GRP78 levels (p<0.01). Conclusions: GRP78 levels are associated with the distribution of adipose tissue and are higher in patients with endometrial cancer.
author	Ciortea,Răzvan Malutan,Andrei M Angheluta,Lenuta M Bucuri,Carmen E Rada,Maria P Mihu,Dan
author_facet	Ciortea,Răzvan Malutan,Andrei M Angheluta,Lenuta M Bucuri,Carmen E Rada,Maria P Mihu,Dan
author_sort	Ciortea,Răzvan
title	GRP78 levels, regional fat distribution and endometrial cáncer
title_short	GRP78 levels, regional fat distribution and endometrial cáncer
title_full	GRP78 levels, regional fat distribution and endometrial cáncer
title_fullStr	GRP78 levels, regional fat distribution and endometrial cáncer
title_full_unstemmed	GRP78 levels, regional fat distribution and endometrial cáncer
title_sort	grp78 levels, regional fat distribution and endometrial cáncer
publisher	Sociedad Médica de Santiago
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016001200009
work_keys_str_mv	AT ciortear259zvan grp78levelsregionalfatdistributionandendometrialcancer AT malutanandreim grp78levelsregionalfatdistributionandendometrialcancer AT anghelutalenutam grp78levelsregionalfatdistributionandendometrialcancer AT bucuricarmene grp78levelsregionalfatdistributionandendometrialcancer AT radamariap grp78levelsregionalfatdistributionandendometrialcancer AT mihudan grp78levelsregionalfatdistributionandendometrialcancer
_version_	1718436920283889664

GRP78 levels, regional fat distribution and endometrial cáncer

Ejemplares similares