Evaluación comparativa entre MELD y Child-Pugh como escalas pronósticas de sobrevida en pacientes con cirrosis hepática en Chile

Background: Currently, most liver units use the Child-Pugh (CP) or the Model for End-Stage Liver Disease (MELD) scores to establish survival prognosis among patients with liver cirrhosis. Which classification is superior, is not well defined. Aim: To compare CP and MELD classification scores to pred...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sanhueza,Edgar, Contreras,Jorge, Zapata,Rodrigo, Sanhueza,Matías, Elgueta,Fabián, López,Constanza, Jerez,Sigrid, Jerez,Verónica, Delgado,Iris
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2017
Materias:	Liver Cirrhosis Liver Transplantation Survival Rate ROC Curve
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872017000100003
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0034-98872017000100003
record_format	dspace
spelling	oai:scielo:S0034-988720170001000032017-05-15Evaluación comparativa entre MELD y Child-Pugh como escalas pronósticas de sobrevida en pacientes con cirrosis hepática en ChileSanhueza,EdgarContreras,JorgeZapata,RodrigoSanhueza,MatíasElgueta,FabiánLópez,ConstanzaJerez,SigridJerez,VerónicaDelgado,Iris Liver Cirrhosis Liver Transplantation Survival Rate ROC Curve Background: Currently, most liver units use the Child-Pugh (CP) or the Model for End-Stage Liver Disease (MELD) scores to establish survival prognosis among patients with liver cirrhosis. Which classification is superior, is not well defined. Aim: To compare CP and MELD classification scores to predict survival among adult patients with liver cirrhosis in Chile. Material and Methods: Follow-up of 137 consecutive adult patients with liver cirrhosis aged 59 ± 12 years (55% women). The diagnosis was reached by clinical, laboratory and image studies at three different centers of Santiago. Patients were staged with CP and MELD classification scores at baseline and followed over a period of 12 months. The predictive capacity of the scores for survival was analyzed using a multivariate statistical analysis (Kaplan-Meier curves). Results: The most common etiology was alcohol (37.9%). The actuarial survival rate was 79.6% at 12 months of follow-up. When comparing groups with areas under curve of receiver operating characteristic curves (AUROC), there was no statistically significant difference in survival between less severe and advanced disease, assessed with both survival scales. The AUROC for MELD and CP were 0.80 and 0.81, respectively. Conclusions: This clinical study did not find a statistically significant difference between the two classifications for the prediction of 12 months survival in patients with cirrhosis.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.145 n.1 20172017-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872017000100003es10.4067/S0034-98872017000100003
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Liver Cirrhosis Liver Transplantation Survival Rate ROC Curve
spellingShingle	Liver Cirrhosis Liver Transplantation Survival Rate ROC Curve Sanhueza,Edgar Contreras,Jorge Zapata,Rodrigo Sanhueza,Matías Elgueta,Fabián López,Constanza Jerez,Sigrid Jerez,Verónica Delgado,Iris Evaluación comparativa entre MELD y Child-Pugh como escalas pronósticas de sobrevida en pacientes con cirrosis hepática en Chile
description	Background: Currently, most liver units use the Child-Pugh (CP) or the Model for End-Stage Liver Disease (MELD) scores to establish survival prognosis among patients with liver cirrhosis. Which classification is superior, is not well defined. Aim: To compare CP and MELD classification scores to predict survival among adult patients with liver cirrhosis in Chile. Material and Methods: Follow-up of 137 consecutive adult patients with liver cirrhosis aged 59 ± 12 years (55% women). The diagnosis was reached by clinical, laboratory and image studies at three different centers of Santiago. Patients were staged with CP and MELD classification scores at baseline and followed over a period of 12 months. The predictive capacity of the scores for survival was analyzed using a multivariate statistical analysis (Kaplan-Meier curves). Results: The most common etiology was alcohol (37.9%). The actuarial survival rate was 79.6% at 12 months of follow-up. When comparing groups with areas under curve of receiver operating characteristic curves (AUROC), there was no statistically significant difference in survival between less severe and advanced disease, assessed with both survival scales. The AUROC for MELD and CP were 0.80 and 0.81, respectively. Conclusions: This clinical study did not find a statistically significant difference between the two classifications for the prediction of 12 months survival in patients with cirrhosis.
author	Sanhueza,Edgar Contreras,Jorge Zapata,Rodrigo Sanhueza,Matías Elgueta,Fabián López,Constanza Jerez,Sigrid Jerez,Verónica Delgado,Iris
author_facet	Sanhueza,Edgar Contreras,Jorge Zapata,Rodrigo Sanhueza,Matías Elgueta,Fabián López,Constanza Jerez,Sigrid Jerez,Verónica Delgado,Iris
author_sort	Sanhueza,Edgar
title	Evaluación comparativa entre MELD y Child-Pugh como escalas pronósticas de sobrevida en pacientes con cirrosis hepática en Chile
title_short	Evaluación comparativa entre MELD y Child-Pugh como escalas pronósticas de sobrevida en pacientes con cirrosis hepática en Chile
title_full	Evaluación comparativa entre MELD y Child-Pugh como escalas pronósticas de sobrevida en pacientes con cirrosis hepática en Chile
title_fullStr	Evaluación comparativa entre MELD y Child-Pugh como escalas pronósticas de sobrevida en pacientes con cirrosis hepática en Chile
title_full_unstemmed	Evaluación comparativa entre MELD y Child-Pugh como escalas pronósticas de sobrevida en pacientes con cirrosis hepática en Chile
title_sort	evaluación comparativa entre meld y child-pugh como escalas pronósticas de sobrevida en pacientes con cirrosis hepática en chile
publisher	Sociedad Médica de Santiago
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872017000100003
work_keys_str_mv	AT sanhuezaedgar evaluacioncomparativaentremeldychildpughcomoescalaspronosticasdesobrevidaenpacientesconcirrosishepaticaenchile AT contrerasjorge evaluacioncomparativaentremeldychildpughcomoescalaspronosticasdesobrevidaenpacientesconcirrosishepaticaenchile AT zapatarodrigo evaluacioncomparativaentremeldychildpughcomoescalaspronosticasdesobrevidaenpacientesconcirrosishepaticaenchile AT sanhuezamatias evaluacioncomparativaentremeldychildpughcomoescalaspronosticasdesobrevidaenpacientesconcirrosishepaticaenchile AT elguetafabian evaluacioncomparativaentremeldychildpughcomoescalaspronosticasdesobrevidaenpacientesconcirrosishepaticaenchile AT lopezconstanza evaluacioncomparativaentremeldychildpughcomoescalaspronosticasdesobrevidaenpacientesconcirrosishepaticaenchile AT jerezsigrid evaluacioncomparativaentremeldychildpughcomoescalaspronosticasdesobrevidaenpacientesconcirrosishepaticaenchile AT jerezveronica evaluacioncomparativaentremeldychildpughcomoescalaspronosticasdesobrevidaenpacientesconcirrosishepaticaenchile AT delgadoiris evaluacioncomparativaentremeldychildpughcomoescalaspronosticasdesobrevidaenpacientesconcirrosishepaticaenchile
_version_	1718436922970341376

Evaluación comparativa entre MELD y Child-Pugh como escalas pronósticas de sobrevida en pacientes con cirrosis hepática en Chile

Ejemplares similares