Caracterización de pacientes con cáncer colorrectal esporádico basado en la nueva subclasificación molecular de consenso

Background: Colorectal cancer (CRC) is an heterogeneous disease. Three carcinogenic pathways determine its molecular profile: microsatellite instability (MSI), chromosomal instability (CIN) and CpG island methylator phenotype (CIMP). Based on the new molecular classification, four consensus CRC mole...

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Autores principales:	Wielandt,Ana María, Villarroel,Cynthia, Hurtado,Claudia, Simian,Daniela, Zamorano,Diego, Martínez,Maripaz, Castro,Magdalena, Vial,María Teresa, Kronberg,Udo, López-Kostner,Francisco
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2017
Materias:	Carcinogenesis Chromosomal Instability Colorectal Neoplasms CpG Island Microsatellite Instability
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872017000400001
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spelling	oai:scielo:S0034-988720170004000012017-07-18Caracterización de pacientes con cáncer colorrectal esporádico basado en la nueva subclasificación molecular de consensoWielandt,Ana MaríaVillarroel,CynthiaHurtado,ClaudiaSimian,DanielaZamorano,DiegoMartínez,MaripazCastro,MagdalenaVial,María TeresaKronberg,UdoLópez-Kostner,Francisco Carcinogenesis Chromosomal Instability Colorectal Neoplasms CpG Island Microsatellite Instability Background: Colorectal cancer (CRC) is an heterogeneous disease. Three carcinogenic pathways determine its molecular profile: microsatellite instability (MSI), chromosomal instability (CIN) and CpG island methylator phenotype (CIMP). Based on the new molecular classification, four consensus CRC molecular subtypes (CMS) are established, which are related to clinical, pathological and biological characteristics of the tumor. Aim: To classify Chilean patients with sporadic CRC according to the new consensus molecular subtypes of carcinogenic pathways. Material and Methods: Prospective analytical study of 53 patients with a mean age of 70 years (55% males) with CRC, operated at a private clinic, without neoadjuvant treatment. From normal and tumor tissue DNA of each patient, CIN, MSI and CIMP were analyzed. Combining these variables, tumors were classified as CMS1/MSI-immune, CMS2/canonical, CMS3/metabolic and CMS4/mesenchymal. Results: CMS1 tumors (19%) were located in the right colon, were in early stages, had MMR complex deficiencies and 67% had an activating mutation of the BRAF oncogene. CMS2 tumors (31%) were located in the left colon, had moderate differentiation, absence of vascular invasion, lymphatic and mucin. CMS3 tumors (29%) were also left-sided, with absence of vascular and lymphatic invasion, and 29% had an activating mutation of the KRAS oncogene. CMS4 tumors (21%) showed advanced stages and presence of metastases. Conclusions: This new molecular classification contributes to understanding the heterogeneity of tumors. It is possible to differentiate molecular subgroups of a single pathological diagnosis of adenocarcinoma, opening the door to personalized medicine.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.145 n.4 20172017-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872017000400001es10.4067/S0034-98872017000400001
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Carcinogenesis Chromosomal Instability Colorectal Neoplasms CpG Island Microsatellite Instability
spellingShingle	Carcinogenesis Chromosomal Instability Colorectal Neoplasms CpG Island Microsatellite Instability Wielandt,Ana María Villarroel,Cynthia Hurtado,Claudia Simian,Daniela Zamorano,Diego Martínez,Maripaz Castro,Magdalena Vial,María Teresa Kronberg,Udo López-Kostner,Francisco Caracterización de pacientes con cáncer colorrectal esporádico basado en la nueva subclasificación molecular de consenso
description	Background: Colorectal cancer (CRC) is an heterogeneous disease. Three carcinogenic pathways determine its molecular profile: microsatellite instability (MSI), chromosomal instability (CIN) and CpG island methylator phenotype (CIMP). Based on the new molecular classification, four consensus CRC molecular subtypes (CMS) are established, which are related to clinical, pathological and biological characteristics of the tumor. Aim: To classify Chilean patients with sporadic CRC according to the new consensus molecular subtypes of carcinogenic pathways. Material and Methods: Prospective analytical study of 53 patients with a mean age of 70 years (55% males) with CRC, operated at a private clinic, without neoadjuvant treatment. From normal and tumor tissue DNA of each patient, CIN, MSI and CIMP were analyzed. Combining these variables, tumors were classified as CMS1/MSI-immune, CMS2/canonical, CMS3/metabolic and CMS4/mesenchymal. Results: CMS1 tumors (19%) were located in the right colon, were in early stages, had MMR complex deficiencies and 67% had an activating mutation of the BRAF oncogene. CMS2 tumors (31%) were located in the left colon, had moderate differentiation, absence of vascular invasion, lymphatic and mucin. CMS3 tumors (29%) were also left-sided, with absence of vascular and lymphatic invasion, and 29% had an activating mutation of the KRAS oncogene. CMS4 tumors (21%) showed advanced stages and presence of metastases. Conclusions: This new molecular classification contributes to understanding the heterogeneity of tumors. It is possible to differentiate molecular subgroups of a single pathological diagnosis of adenocarcinoma, opening the door to personalized medicine.
author	Wielandt,Ana María Villarroel,Cynthia Hurtado,Claudia Simian,Daniela Zamorano,Diego Martínez,Maripaz Castro,Magdalena Vial,María Teresa Kronberg,Udo López-Kostner,Francisco
author_facet	Wielandt,Ana María Villarroel,Cynthia Hurtado,Claudia Simian,Daniela Zamorano,Diego Martínez,Maripaz Castro,Magdalena Vial,María Teresa Kronberg,Udo López-Kostner,Francisco
author_sort	Wielandt,Ana María
title	Caracterización de pacientes con cáncer colorrectal esporádico basado en la nueva subclasificación molecular de consenso
title_short	Caracterización de pacientes con cáncer colorrectal esporádico basado en la nueva subclasificación molecular de consenso
title_full	Caracterización de pacientes con cáncer colorrectal esporádico basado en la nueva subclasificación molecular de consenso
title_fullStr	Caracterización de pacientes con cáncer colorrectal esporádico basado en la nueva subclasificación molecular de consenso
title_full_unstemmed	Caracterización de pacientes con cáncer colorrectal esporádico basado en la nueva subclasificación molecular de consenso
title_sort	caracterización de pacientes con cáncer colorrectal esporádico basado en la nueva subclasificación molecular de consenso
publisher	Sociedad Médica de Santiago
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872017000400001
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Caracterización de pacientes con cáncer colorrectal esporádico basado en la nueva subclasificación molecular de consenso

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