Caracterización de pacientes controlados por enfermedad de Basedow Graves en un hospital universitario

Background: Basedow Graves disease (BGD) is the leading cause of hyperthyroidism. The characteristics of patients seen at a university hospital may differ from those described in the general population. Aim: To describe the clinical features of patients with BGD seen at a university hospital. Materi...

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Autores principales:	Lanas,Alejandra, Díaz,Patricia, Eugenin,Daniela, González,Franco, Cid,Pía, Cordero,Francisco, Araya,Verónica, Liberman,Claudio, Barberan,Marcela, Gac,Patricio, Saldías,Neil, Pineda,Pedro
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2017
Materias:	Graves Disease Hyperthyroidism Thyroidectomy
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872017000400003
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spelling	oai:scielo:S0034-988720170004000032017-07-18Caracterización de pacientes controlados por enfermedad de Basedow Graves en un hospital universitarioLanas,AlejandraDíaz,PatriciaEugenin,DanielaGonzález,FrancoCid,PíaCordero,FranciscoAraya,VerónicaLiberman,ClaudioBarberan,MarcelaGac,PatricioSaldías,NeilPineda,Pedro Graves Disease Hyperthyroidism Thyroidectomy Background: Basedow Graves disease (BGD) is the leading cause of hyperthyroidism. The characteristics of patients seen at a university hospital may differ from those described in the general population. Aim: To describe the clinical features of patients with BGD seen at a university hospital. Material and Methods: Review of medical records of all patients seen at our hospital between 2009 and 2014 with the diagnosis of thyrotoxicosis, hyperthyroidism or BGD. Clinical features, laboratory results and treatments were recorded. Results: We reviewed clinical records of 272 patients; 15 had to be excluded due to incomplete data. BGD was present in 77.9% (n = 212). The mean age of the latter was 42 years (range 10-81) and 76% were women. Ninety six percent were hyperthyroid at diagnosis and thyroid stimulating hormone was below 0.1 mIU/L in all patients. Median free thyroxin and triiodothyronine levels were 3.26 ng/dl and 3.16 ng/ml, respectively. Thyrotropin-receptor antibodies were positive in 98.5% and 85.7% had positive thyroid peroxidase antibodies. Graves orbitopathy (GO) was clinically present in 55% of patients. Of this group, 47% had an active GO, 26% had a moderate to severe disease and 7.8% had sight-threatening GO. As treatment, 26% received radioiodine, 44% anti-thyroid drugs exclusively, 28% underwent thyroidectomy and 2% did not require therapy. Conclusions: In this group of patients, we observed a greater frequency of severe eye disease and a high rate of surgical management. This finding could be explained by referral to highly qualified surgical and ophthalmological teams.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.145 n.4 20172017-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872017000400003es10.4067/S0034-98872017000400003
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Graves Disease Hyperthyroidism Thyroidectomy
spellingShingle	Graves Disease Hyperthyroidism Thyroidectomy Lanas,Alejandra Díaz,Patricia Eugenin,Daniela González,Franco Cid,Pía Cordero,Francisco Araya,Verónica Liberman,Claudio Barberan,Marcela Gac,Patricio Saldías,Neil Pineda,Pedro Caracterización de pacientes controlados por enfermedad de Basedow Graves en un hospital universitario
description	Background: Basedow Graves disease (BGD) is the leading cause of hyperthyroidism. The characteristics of patients seen at a university hospital may differ from those described in the general population. Aim: To describe the clinical features of patients with BGD seen at a university hospital. Material and Methods: Review of medical records of all patients seen at our hospital between 2009 and 2014 with the diagnosis of thyrotoxicosis, hyperthyroidism or BGD. Clinical features, laboratory results and treatments were recorded. Results: We reviewed clinical records of 272 patients; 15 had to be excluded due to incomplete data. BGD was present in 77.9% (n = 212). The mean age of the latter was 42 years (range 10-81) and 76% were women. Ninety six percent were hyperthyroid at diagnosis and thyroid stimulating hormone was below 0.1 mIU/L in all patients. Median free thyroxin and triiodothyronine levels were 3.26 ng/dl and 3.16 ng/ml, respectively. Thyrotropin-receptor antibodies were positive in 98.5% and 85.7% had positive thyroid peroxidase antibodies. Graves orbitopathy (GO) was clinically present in 55% of patients. Of this group, 47% had an active GO, 26% had a moderate to severe disease and 7.8% had sight-threatening GO. As treatment, 26% received radioiodine, 44% anti-thyroid drugs exclusively, 28% underwent thyroidectomy and 2% did not require therapy. Conclusions: In this group of patients, we observed a greater frequency of severe eye disease and a high rate of surgical management. This finding could be explained by referral to highly qualified surgical and ophthalmological teams.
author	Lanas,Alejandra Díaz,Patricia Eugenin,Daniela González,Franco Cid,Pía Cordero,Francisco Araya,Verónica Liberman,Claudio Barberan,Marcela Gac,Patricio Saldías,Neil Pineda,Pedro
author_facet	Lanas,Alejandra Díaz,Patricia Eugenin,Daniela González,Franco Cid,Pía Cordero,Francisco Araya,Verónica Liberman,Claudio Barberan,Marcela Gac,Patricio Saldías,Neil Pineda,Pedro
author_sort	Lanas,Alejandra
title	Caracterización de pacientes controlados por enfermedad de Basedow Graves en un hospital universitario
title_short	Caracterización de pacientes controlados por enfermedad de Basedow Graves en un hospital universitario
title_full	Caracterización de pacientes controlados por enfermedad de Basedow Graves en un hospital universitario
title_fullStr	Caracterización de pacientes controlados por enfermedad de Basedow Graves en un hospital universitario
title_full_unstemmed	Caracterización de pacientes controlados por enfermedad de Basedow Graves en un hospital universitario
title_sort	caracterización de pacientes controlados por enfermedad de basedow graves en un hospital universitario
publisher	Sociedad Médica de Santiago
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872017000400003
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Caracterización de pacientes controlados por enfermedad de Basedow Graves en un hospital universitario

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