Evolución del protocolo de trombolisis endovenosa en ataque cerebrovascular isquémico agudo

Background: Intravenous thrombolysis (IVT) with alteplase (tissue plasminogen activator) is the standard pharmacological treatment in acute ischemic stroke (AIS), reducing disability in patients. Aim: To report the results a thrombolysis protocol during four years in a regional public hospital. Mate...

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Autores principales:	Soto V,Álvaro, Morales I,Gladys, Grandjean B,Marcela, Pollak W,Débora, del Castillo C,Carolina, García F,Pía, Von Johnn A,Alexis, Riquelme G,Alfonso
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2017
Materias:	Fibrinolytic Therapy Stroke Time-to-Treatment Thrombolytic Therapy Tissue Plasminogen Activator
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872017000400007
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spelling	oai:scielo:S0034-988720170004000072017-07-18Evolución del protocolo de trombolisis endovenosa en ataque cerebrovascular isquémico agudoSoto V,ÁlvaroMorales I,GladysGrandjean B,MarcelaPollak W,Déboradel Castillo C,CarolinaGarcía F,PíaVon Johnn A,AlexisRiquelme G,Alfonso Fibrinolytic Therapy Stroke Time-to-Treatment Thrombolytic Therapy Tissue Plasminogen Activator Background: Intravenous thrombolysis (IVT) with alteplase (tissue plasminogen activator) is the standard pharmacological treatment in acute ischemic stroke (AIS), reducing disability in patients. Aim: To report the results a thrombolysis protocol during four years in a regional public hospital. Material and Methods: Data from 106 consecutive patients aged 68 ± 13 years (57% men) who were treated with IVT, from May 2012 until April 2016, was analyzed. Results: The median door-to-needle time was 80 minutes (interquartile range = 57-113). The median National Institute of Health Stroke Scale (NIHSS) scores on admission and at discharge were was 11.5 and 5 points respectively. At discharge, 27% of hospitalized patients had a favorable outcome (n = 99), defined as having 0 to 1 points in the modified Rankin scale. Symptomatic intracerebral hemorrhage and mortality rates were 5.7 and 13.1%, respectively. The thrombolysis rate rose from 0.7% in 2012 to 6% in 2016. Conclusions: The implementation of 24/7 neurology shifts in the Emergency Department allowed us to increase the amount and quality of IVT in our hospital, as measured by the rate of thrombolysis and by process indicators such as door-to-needle time.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.145 n.4 20172017-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872017000400007es10.4067/S0034-98872017000400007
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Fibrinolytic Therapy Stroke Time-to-Treatment Thrombolytic Therapy Tissue Plasminogen Activator
spellingShingle	Fibrinolytic Therapy Stroke Time-to-Treatment Thrombolytic Therapy Tissue Plasminogen Activator Soto V,Álvaro Morales I,Gladys Grandjean B,Marcela Pollak W,Débora del Castillo C,Carolina García F,Pía Von Johnn A,Alexis Riquelme G,Alfonso Evolución del protocolo de trombolisis endovenosa en ataque cerebrovascular isquémico agudo
description	Background: Intravenous thrombolysis (IVT) with alteplase (tissue plasminogen activator) is the standard pharmacological treatment in acute ischemic stroke (AIS), reducing disability in patients. Aim: To report the results a thrombolysis protocol during four years in a regional public hospital. Material and Methods: Data from 106 consecutive patients aged 68 ± 13 years (57% men) who were treated with IVT, from May 2012 until April 2016, was analyzed. Results: The median door-to-needle time was 80 minutes (interquartile range = 57-113). The median National Institute of Health Stroke Scale (NIHSS) scores on admission and at discharge were was 11.5 and 5 points respectively. At discharge, 27% of hospitalized patients had a favorable outcome (n = 99), defined as having 0 to 1 points in the modified Rankin scale. Symptomatic intracerebral hemorrhage and mortality rates were 5.7 and 13.1%, respectively. The thrombolysis rate rose from 0.7% in 2012 to 6% in 2016. Conclusions: The implementation of 24/7 neurology shifts in the Emergency Department allowed us to increase the amount and quality of IVT in our hospital, as measured by the rate of thrombolysis and by process indicators such as door-to-needle time.
author	Soto V,Álvaro Morales I,Gladys Grandjean B,Marcela Pollak W,Débora del Castillo C,Carolina García F,Pía Von Johnn A,Alexis Riquelme G,Alfonso
author_facet	Soto V,Álvaro Morales I,Gladys Grandjean B,Marcela Pollak W,Débora del Castillo C,Carolina García F,Pía Von Johnn A,Alexis Riquelme G,Alfonso
author_sort	Soto V,Álvaro
title	Evolución del protocolo de trombolisis endovenosa en ataque cerebrovascular isquémico agudo
title_short	Evolución del protocolo de trombolisis endovenosa en ataque cerebrovascular isquémico agudo
title_full	Evolución del protocolo de trombolisis endovenosa en ataque cerebrovascular isquémico agudo
title_fullStr	Evolución del protocolo de trombolisis endovenosa en ataque cerebrovascular isquémico agudo
title_full_unstemmed	Evolución del protocolo de trombolisis endovenosa en ataque cerebrovascular isquémico agudo
title_sort	evolución del protocolo de trombolisis endovenosa en ataque cerebrovascular isquémico agudo
publisher	Sociedad Médica de Santiago
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872017000400007
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Evolución del protocolo de trombolisis endovenosa en ataque cerebrovascular isquémico agudo

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