Clinical applications of pharmacogenomics

Pharmacogenomics is an emergent field aimed at tailoring pharmacological therapy. Genetic polymorphisms can modify the expression and function of enzymes and proteins involved in drug metabolism, affecting absorption, distribution, biotransformation and excretion as well as the drug-target interacti...

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Autores principales:	Quiñones,Luis, Roco,Ángela, Cayún,Juan P, Escalante,Paula, Miranda,Carla, Varela,Nelson, Meneses,Francisca, Gallegos,Bastián, Zaruma-Torres,Fausto, Lares-Asseff,Ismael
Lenguaje:	English
Publicado:	Sociedad Médica de Santiago 2017
Materias:	Pharmacogenetics Pharmacokinetics Pharmacogenomic variants Polymorphisms Genetic
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872017000400009
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spelling	oai:scielo:S0034-988720170004000092017-07-18Clinical applications of pharmacogenomicsQuiñones,LuisRoco,ÁngelaCayún,Juan PEscalante,PaulaMiranda,CarlaVarela,NelsonMeneses,FranciscaGallegos,BastiánZaruma-Torres,FaustoLares-Asseff,Ismael Pharmacogenetics Pharmacokinetics Pharmacogenomic variants Polymorphisms Genetic Pharmacogenomics is an emergent field aimed at tailoring pharmacological therapy. Genetic polymorphisms can modify the expression and function of enzymes and proteins involved in drug metabolism, affecting absorption, distribution, biotransformation and excretion as well as the drug-target interaction. Therefore, the presence of allelic variants will classify people as poor, extensive or rapid/ultra rapid metabolizers, modifying drug efficacy and safety. In this work, the state of art in relation to this discipline is presented and the genetic variants of enzymes that are involved in drug pharmacokinetics or pharmacodynamics are described. The effects of these variants on the therapeutic response to drugs used in our country are also discussed.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.145 n.4 20172017-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872017000400009en10.4067/S0034-98872017000400009
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Pharmacogenetics Pharmacokinetics Pharmacogenomic variants Polymorphisms Genetic
spellingShingle	Pharmacogenetics Pharmacokinetics Pharmacogenomic variants Polymorphisms Genetic Quiñones,Luis Roco,Ángela Cayún,Juan P Escalante,Paula Miranda,Carla Varela,Nelson Meneses,Francisca Gallegos,Bastián Zaruma-Torres,Fausto Lares-Asseff,Ismael Clinical applications of pharmacogenomics
description	Pharmacogenomics is an emergent field aimed at tailoring pharmacological therapy. Genetic polymorphisms can modify the expression and function of enzymes and proteins involved in drug metabolism, affecting absorption, distribution, biotransformation and excretion as well as the drug-target interaction. Therefore, the presence of allelic variants will classify people as poor, extensive or rapid/ultra rapid metabolizers, modifying drug efficacy and safety. In this work, the state of art in relation to this discipline is presented and the genetic variants of enzymes that are involved in drug pharmacokinetics or pharmacodynamics are described. The effects of these variants on the therapeutic response to drugs used in our country are also discussed.
author	Quiñones,Luis Roco,Ángela Cayún,Juan P Escalante,Paula Miranda,Carla Varela,Nelson Meneses,Francisca Gallegos,Bastián Zaruma-Torres,Fausto Lares-Asseff,Ismael
author_facet	Quiñones,Luis Roco,Ángela Cayún,Juan P Escalante,Paula Miranda,Carla Varela,Nelson Meneses,Francisca Gallegos,Bastián Zaruma-Torres,Fausto Lares-Asseff,Ismael
author_sort	Quiñones,Luis
title	Clinical applications of pharmacogenomics
title_short	Clinical applications of pharmacogenomics
title_full	Clinical applications of pharmacogenomics
title_fullStr	Clinical applications of pharmacogenomics
title_full_unstemmed	Clinical applications of pharmacogenomics
title_sort	clinical applications of pharmacogenomics
publisher	Sociedad Médica de Santiago
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872017000400009
work_keys_str_mv	AT quinonesluis clinicalapplicationsofpharmacogenomics AT rocoangela clinicalapplicationsofpharmacogenomics AT cayunjuanp clinicalapplicationsofpharmacogenomics AT escalantepaula clinicalapplicationsofpharmacogenomics AT mirandacarla clinicalapplicationsofpharmacogenomics AT varelanelson clinicalapplicationsofpharmacogenomics AT menesesfrancisca clinicalapplicationsofpharmacogenomics AT gallegosbastian clinicalapplicationsofpharmacogenomics AT zarumatorresfausto clinicalapplicationsofpharmacogenomics AT laresasseffismael clinicalapplicationsofpharmacogenomics
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Clinical applications of pharmacogenomics

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