Vigencia del efecto placebo: su biología desde la genética a la conducta
The placebo effect has been seldom studied in the history of medicine. However, during the last decades, the great impact of this phenomenon in clinical practice, ranging from surgical to psychiatric field, has been revealed. Research elucidated both the psychological mechanisms and genetic polymorp...
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| Lenguaje: | Spanish / Castilian |
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Sociedad Médica de Santiago
2017
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oai:scielo:S0034-988720170006007752017-11-17Vigencia del efecto placebo: su biología desde la genética a la conductaAceituno V.,DianaSantander,Jaime Genetics Neurobiology Nocebo Effect Placebo Effect The placebo effect has been seldom studied in the history of medicine. However, during the last decades, the great impact of this phenomenon in clinical practice, ranging from surgical to psychiatric field, has been revealed. Research elucidated both the psychological mechanisms and genetic polymorphisms that affect the susceptibility of individuals to express this phenomenon. We herein review the psychological mechanisms, brain structures (anterior cingulate cortex, nucleus accumbens, dorsolateral prefrontal cortex, insular cortex, thalamus) and neurotransmission systems involved (opioid, dopaminergic, cannabinoid, serotoninergic, cholecystokinin). These are the clue to recognize the polymorphisms that have been identified so far. The biological basis of both the placebo effect and its alter ego, the nocebo effect, are well recognized, and related to corresponding psychological processes. Finally, the implications of the findings in clinical practice and medical training are discussed.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.145 n.6 20172017-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872017000600775es10.4067/s0034-98872017000600775 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
Spanish / Castilian |
| topic |
Genetics Neurobiology Nocebo Effect Placebo Effect |
| spellingShingle |
Genetics Neurobiology Nocebo Effect Placebo Effect Aceituno V.,Diana Santander,Jaime Vigencia del efecto placebo: su biología desde la genética a la conducta |
| description |
The placebo effect has been seldom studied in the history of medicine. However, during the last decades, the great impact of this phenomenon in clinical practice, ranging from surgical to psychiatric field, has been revealed. Research elucidated both the psychological mechanisms and genetic polymorphisms that affect the susceptibility of individuals to express this phenomenon. We herein review the psychological mechanisms, brain structures (anterior cingulate cortex, nucleus accumbens, dorsolateral prefrontal cortex, insular cortex, thalamus) and neurotransmission systems involved (opioid, dopaminergic, cannabinoid, serotoninergic, cholecystokinin). These are the clue to recognize the polymorphisms that have been identified so far. The biological basis of both the placebo effect and its alter ego, the nocebo effect, are well recognized, and related to corresponding psychological processes. Finally, the implications of the findings in clinical practice and medical training are discussed. |
| author |
Aceituno V.,Diana Santander,Jaime |
| author_facet |
Aceituno V.,Diana Santander,Jaime |
| author_sort |
Aceituno V.,Diana |
| title |
Vigencia del efecto placebo: su biología desde la genética a la conducta |
| title_short |
Vigencia del efecto placebo: su biología desde la genética a la conducta |
| title_full |
Vigencia del efecto placebo: su biología desde la genética a la conducta |
| title_fullStr |
Vigencia del efecto placebo: su biología desde la genética a la conducta |
| title_full_unstemmed |
Vigencia del efecto placebo: su biología desde la genética a la conducta |
| title_sort |
vigencia del efecto placebo: su biología desde la genética a la conducta |
| publisher |
Sociedad Médica de Santiago |
| publishDate |
2017 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872017000600775 |
| work_keys_str_mv |
AT aceitunovdiana vigenciadelefectoplacebosubiologiadesdelageneticaalaconducta AT santanderjaime vigenciadelefectoplacebosubiologiadesdelageneticaalaconducta |
| _version_ |
1718436950089662464 |