Epigenética del síndrome de ovario poliquístico

Polycystic ovarian syndrome (PCOS) is an endocrine and metabolic dysfunction, highly prevalent in women in their reproductive years. Hyperandrogenism, oligo-ovulation, polycystic ovarian morphology are the main features of this syndrome. PCOS is a genetic disorder with a multifactorial etiology and...

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Autores principales:	Concha C.,Francisca, Sir P.,Teresa, Recabarren,Sergio E., Pérez B.,Francisco
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2017
Materias:	Epigenomics Genes, Regulator Polycystic Ovary Syndrome
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872017000700907
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spelling	oai:scielo:S0034-988720170007009072017-11-27Epigenética del síndrome de ovario poliquísticoConcha C.,FranciscaSir P.,TeresaRecabarren,Sergio E.Pérez B.,Francisco Epigenomics Genes, Regulator Polycystic Ovary Syndrome Polycystic ovarian syndrome (PCOS) is an endocrine and metabolic dysfunction, highly prevalent in women in their reproductive years. Hyperandrogenism, oligo-ovulation, polycystic ovarian morphology are the main features of this syndrome. PCOS is a genetic disorder with a multifactorial etiology and has a strong link with environmental components. It is frequently associated with obesity and insulin resistance. Recently, epigenetic mechanisms have been involved in the pathogenesis of PCOS. Several studies showed that methylation in DNA and miRNAs is altered in women with PCOS in blood, serum, adipose tissue, granulose cells and theca. This evidence indicates that women with PCOS have a different epigenetic regulation, which might be triggered by an adverse intrauterine environment or by postnatal environmental elements such as diet and or obesity.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.145 n.7 20172017-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872017000700907es10.4067/s0034-98872017000700907
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Epigenomics Genes, Regulator Polycystic Ovary Syndrome
spellingShingle	Epigenomics Genes, Regulator Polycystic Ovary Syndrome Concha C.,Francisca Sir P.,Teresa Recabarren,Sergio E. Pérez B.,Francisco Epigenética del síndrome de ovario poliquístico
description	Polycystic ovarian syndrome (PCOS) is an endocrine and metabolic dysfunction, highly prevalent in women in their reproductive years. Hyperandrogenism, oligo-ovulation, polycystic ovarian morphology are the main features of this syndrome. PCOS is a genetic disorder with a multifactorial etiology and has a strong link with environmental components. It is frequently associated with obesity and insulin resistance. Recently, epigenetic mechanisms have been involved in the pathogenesis of PCOS. Several studies showed that methylation in DNA and miRNAs is altered in women with PCOS in blood, serum, adipose tissue, granulose cells and theca. This evidence indicates that women with PCOS have a different epigenetic regulation, which might be triggered by an adverse intrauterine environment or by postnatal environmental elements such as diet and or obesity.
author	Concha C.,Francisca Sir P.,Teresa Recabarren,Sergio E. Pérez B.,Francisco
author_facet	Concha C.,Francisca Sir P.,Teresa Recabarren,Sergio E. Pérez B.,Francisco
author_sort	Concha C.,Francisca
title	Epigenética del síndrome de ovario poliquístico
title_short	Epigenética del síndrome de ovario poliquístico
title_full	Epigenética del síndrome de ovario poliquístico
title_fullStr	Epigenética del síndrome de ovario poliquístico
title_full_unstemmed	Epigenética del síndrome de ovario poliquístico
title_sort	epigenética del síndrome de ovario poliquístico
publisher	Sociedad Médica de Santiago
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872017000700907
work_keys_str_mv	AT conchacfrancisca epigeneticadelsindromedeovariopoliquistico AT sirpteresa epigeneticadelsindromedeovariopoliquistico AT recabarrensergioe epigeneticadelsindromedeovariopoliquistico AT perezbfrancisco epigeneticadelsindromedeovariopoliquistico
_version_	1718436955261239296

Epigenética del síndrome de ovario poliquístico

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