Miastenia gravis y su asociación con trastornos linfoproliferativos: casos clínicos

Myasthenia gravis (MG) is a rare autoimmune disease of the neuromuscular junction. It is characterized by variable weakness and excessive fatigability of skeletal muscles. In the last few years, numerous reports have been published showing the association between autoimmune diseases, such as systemi...

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Autores principales:	Cea,Gabriel, Gallardo V.,Andrés, Cabrera C.,María Elena
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2017
Materias:	Autoimmune Diseases B Cell Chile Chronic B-Cell Leukemia, Lymphocytic Lymphoma, B-Cell Lymphoproliferative disorders Myasthenia Gravis Plasmacytoma
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872017001201626
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:scielo:S0034-988720170012016262018-04-06Miastenia gravis y su asociación con trastornos linfoproliferativos: casos clínicosCea,GabrielGallardo V.,AndrésCabrera C.,María Elena Autoimmune Diseases B Cell Chile Chronic B-Cell Leukemia, Lymphocytic Lymphoma, B-Cell Lymphoproliferative disorders Myasthenia Gravis Plasmacytoma Myasthenia gravis (MG) is a rare autoimmune disease of the neuromuscular junction. It is characterized by variable weakness and excessive fatigability of skeletal muscles. In the last few years, numerous reports have been published showing the association between autoimmune diseases, such as systemic erythematous lupus or rheumatoid arthritis, with lymphoid neoplasias. The association between MG and lymphoid neoplasia seems to be less frequent. To analyze this association we reviewed the MG patients in the Department of Neurology, Hospital Salvador of Santiago, Chile. During a three-year period we identified four patients who developed different lymphoproliferative disorders: two with B-cell lymphoma, one with chronic lymphocytic leukaemia and one plasmacytoma with an associated amyloidosis. The MG was generalized but mild, all cases classified as type IIa according to the definition proposed by the MG Foundation of America. The neoplasia appeared two to 36 years after the onset of MG. These cases provide additional evidence of the association between MG and lymphoproliferative disorders.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.145 n.12 20172017-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872017001201626es10.4067/s0034-98872017001201626
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Autoimmune Diseases B Cell Chile Chronic B-Cell Leukemia, Lymphocytic Lymphoma, B-Cell Lymphoproliferative disorders Myasthenia Gravis Plasmacytoma
spellingShingle	Autoimmune Diseases B Cell Chile Chronic B-Cell Leukemia, Lymphocytic Lymphoma, B-Cell Lymphoproliferative disorders Myasthenia Gravis Plasmacytoma Cea,Gabriel Gallardo V.,Andrés Cabrera C.,María Elena Miastenia gravis y su asociación con trastornos linfoproliferativos: casos clínicos
description	Myasthenia gravis (MG) is a rare autoimmune disease of the neuromuscular junction. It is characterized by variable weakness and excessive fatigability of skeletal muscles. In the last few years, numerous reports have been published showing the association between autoimmune diseases, such as systemic erythematous lupus or rheumatoid arthritis, with lymphoid neoplasias. The association between MG and lymphoid neoplasia seems to be less frequent. To analyze this association we reviewed the MG patients in the Department of Neurology, Hospital Salvador of Santiago, Chile. During a three-year period we identified four patients who developed different lymphoproliferative disorders: two with B-cell lymphoma, one with chronic lymphocytic leukaemia and one plasmacytoma with an associated amyloidosis. The MG was generalized but mild, all cases classified as type IIa according to the definition proposed by the MG Foundation of America. The neoplasia appeared two to 36 years after the onset of MG. These cases provide additional evidence of the association between MG and lymphoproliferative disorders.
author	Cea,Gabriel Gallardo V.,Andrés Cabrera C.,María Elena
author_facet	Cea,Gabriel Gallardo V.,Andrés Cabrera C.,María Elena
author_sort	Cea,Gabriel
title	Miastenia gravis y su asociación con trastornos linfoproliferativos: casos clínicos
title_short	Miastenia gravis y su asociación con trastornos linfoproliferativos: casos clínicos
title_full	Miastenia gravis y su asociación con trastornos linfoproliferativos: casos clínicos
title_fullStr	Miastenia gravis y su asociación con trastornos linfoproliferativos: casos clínicos
title_full_unstemmed	Miastenia gravis y su asociación con trastornos linfoproliferativos: casos clínicos
title_sort	miastenia gravis y su asociación con trastornos linfoproliferativos: casos clínicos
publisher	Sociedad Médica de Santiago
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872017001201626
work_keys_str_mv	AT ceagabriel miasteniagravisysuasociacioncontrastornoslinfoproliferativoscasosclinicos AT gallardovandres miasteniagravisysuasociacioncontrastornoslinfoproliferativoscasosclinicos AT cabreracmariaelena miasteniagravisysuasociacioncontrastornoslinfoproliferativoscasosclinicos
_version_	1718436983094640640

Miastenia gravis y su asociación con trastornos linfoproliferativos: casos clínicos

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