Sensibilidad diagnóstica de electroforesis de proteínas y cadenas livianas libres séricas en gammapatías monoclonales

Background: International guidelines suggest a screening panel for monoclonal gammopathies that contains serum protein electrophoresis (SPE), free light chain (FLC) measurements and immunofixation. This combination provides the possibility of a timely accurate diagnosis. Aim: To evaluate the sensi...

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Autores principales:	Peña,Camila, Ortiz,Manuela, Voisin,Javier, Peralta,Alexis, Balboa,Viviana, Delgado,Florencia
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2018
Materias:	Diagnosis Multiple Myeloma Paraproteinemias
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000100064
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spelling	oai:scielo:S0034-988720180001000642018-05-11Sensibilidad diagnóstica de electroforesis de proteínas y cadenas livianas libres séricas en gammapatías monoclonalesPeña,CamilaOrtiz,ManuelaVoisin,JavierPeralta,AlexisBalboa,VivianaDelgado,Florencia Diagnosis Multiple Myeloma Paraproteinemias Background: International guidelines suggest a screening panel for monoclonal gammopathies that contains serum protein electrophoresis (SPE), free light chain (FLC) measurements and immunofixation. This combination provides the possibility of a timely accurate diagnosis. Aim: To evaluate the sensibility of a simple screening panel (SPE + FLC). Material and Methods: We analyzed 191 consecutive serum samples of patients with a suspected monoclonal gammopathy (MG). Results: Seventy five patients were diagnosed with MG. The sensitivity and specificity of the combination of SPE + FLC for the diagnosis of monoclonal gammopathy were 95% (95% confidence intervals 89-99) and 99% (95% confidence intervals 96-100), respectively. Conclusions: We were able to validate the international recommendations on the diagnostic accuracy of this simple combination of two tests in serum for monoclonal gammopathy.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.146 n.1 20182018-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000100064es10.4067/s0034-98872018000100064
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Diagnosis Multiple Myeloma Paraproteinemias
spellingShingle	Diagnosis Multiple Myeloma Paraproteinemias Peña,Camila Ortiz,Manuela Voisin,Javier Peralta,Alexis Balboa,Viviana Delgado,Florencia Sensibilidad diagnóstica de electroforesis de proteínas y cadenas livianas libres séricas en gammapatías monoclonales
description	Background: International guidelines suggest a screening panel for monoclonal gammopathies that contains serum protein electrophoresis (SPE), free light chain (FLC) measurements and immunofixation. This combination provides the possibility of a timely accurate diagnosis. Aim: To evaluate the sensibility of a simple screening panel (SPE + FLC). Material and Methods: We analyzed 191 consecutive serum samples of patients with a suspected monoclonal gammopathy (MG). Results: Seventy five patients were diagnosed with MG. The sensitivity and specificity of the combination of SPE + FLC for the diagnosis of monoclonal gammopathy were 95% (95% confidence intervals 89-99) and 99% (95% confidence intervals 96-100), respectively. Conclusions: We were able to validate the international recommendations on the diagnostic accuracy of this simple combination of two tests in serum for monoclonal gammopathy.
author	Peña,Camila Ortiz,Manuela Voisin,Javier Peralta,Alexis Balboa,Viviana Delgado,Florencia
author_facet	Peña,Camila Ortiz,Manuela Voisin,Javier Peralta,Alexis Balboa,Viviana Delgado,Florencia
author_sort	Peña,Camila
title	Sensibilidad diagnóstica de electroforesis de proteínas y cadenas livianas libres séricas en gammapatías monoclonales
title_short	Sensibilidad diagnóstica de electroforesis de proteínas y cadenas livianas libres séricas en gammapatías monoclonales
title_full	Sensibilidad diagnóstica de electroforesis de proteínas y cadenas livianas libres séricas en gammapatías monoclonales
title_fullStr	Sensibilidad diagnóstica de electroforesis de proteínas y cadenas livianas libres séricas en gammapatías monoclonales
title_full_unstemmed	Sensibilidad diagnóstica de electroforesis de proteínas y cadenas livianas libres séricas en gammapatías monoclonales
title_sort	sensibilidad diagnóstica de electroforesis de proteínas y cadenas livianas libres séricas en gammapatías monoclonales
publisher	Sociedad Médica de Santiago
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000100064
work_keys_str_mv	AT penacamila sensibilidaddiagnosticadeelectroforesisdeproteinasycadenaslivianaslibressericasengammapatiasmonoclonales AT ortizmanuela sensibilidaddiagnosticadeelectroforesisdeproteinasycadenaslivianaslibressericasengammapatiasmonoclonales AT voisinjavier sensibilidaddiagnosticadeelectroforesisdeproteinasycadenaslivianaslibressericasengammapatiasmonoclonales AT peraltaalexis sensibilidaddiagnosticadeelectroforesisdeproteinasycadenaslivianaslibressericasengammapatiasmonoclonales AT balboaviviana sensibilidaddiagnosticadeelectroforesisdeproteinasycadenaslivianaslibressericasengammapatiasmonoclonales AT delgadoflorencia sensibilidaddiagnosticadeelectroforesisdeproteinasycadenaslivianaslibressericasengammapatiasmonoclonales
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Sensibilidad diagnóstica de electroforesis de proteínas y cadenas livianas libres séricas en gammapatías monoclonales

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