Aplasia medular adquirida, experiencia en un hospital público de referencia

Background: The first line treatment for patients < 40 years old with aplastic anemia (AA) is allogeneic HLA-identical sibling donor transplantation (SCT). Immunosuppressive therapy (IST) with a combination of Thymoglobuline (ATG) and cyclosporine is used for older patients or those without a do...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	León,Pilar, Cardemil,Daniela, Osorio,Rocío, Peña,Camila, Valladares,Ximena, Puga,Bárbara, Cabrera,María Elena
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2018
Materias:	Anemia Aplastic Homologous Immunosuppression Stem Cell Transplantation Transplantation
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000200175
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0034-98872018000200175
record_format	dspace
spelling	oai:scielo:S0034-988720180002001752018-06-20Aplasia medular adquirida, experiencia en un hospital público de referenciaLeón,PilarCardemil,DanielaOsorio,RocíoPeña,CamilaValladares,XimenaPuga,BárbaraCabrera,María Elena Anemia Aplastic Homologous Immunosuppression Stem Cell Transplantation Transplantation Background: The first line treatment for patients < 40 years old with aplastic anemia (AA) is allogeneic HLA-identical sibling donor transplantation (SCT). Immunosuppressive therapy (IST) with a combination of Thymoglobuline (ATG) and cyclosporine is used for older patients or those without a donor. Five year overall survival (OS) for both therapies is > 70%. Aim: To report the experience with SCT and ATG for AA in a public hospital. Patients and Methods: AA was diagnosed in 42 patients between 1998 and 2016, according to Camitta criteria. Thirty eight (90%) received treatment, 7 (18%) under 40 years old received SCT, and 31 (82%) IST. The rest were not treated. OS was calculated from date of diagnosis until last control, death or loss from follow up. Results: Complete or partial hematologic response, was obtained in 71% and 58% of cases with SCT and IS, respectively. Five year OS was 71% and 55% with SCT and IST, respectively. No difference in response was observed between horse and rabbit ATG. Conclusions: SCT from an HLA-identical sibling donor had a high response rate and survival. IST instead, had a lower response and survival, due to an initial high mortality rate.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.146 n.2 20182018-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000200175es10.4067/s0034-98872018000200175
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Anemia Aplastic Homologous Immunosuppression Stem Cell Transplantation Transplantation
spellingShingle	Anemia Aplastic Homologous Immunosuppression Stem Cell Transplantation Transplantation León,Pilar Cardemil,Daniela Osorio,Rocío Peña,Camila Valladares,Ximena Puga,Bárbara Cabrera,María Elena Aplasia medular adquirida, experiencia en un hospital público de referencia
description	Background: The first line treatment for patients < 40 years old with aplastic anemia (AA) is allogeneic HLA-identical sibling donor transplantation (SCT). Immunosuppressive therapy (IST) with a combination of Thymoglobuline (ATG) and cyclosporine is used for older patients or those without a donor. Five year overall survival (OS) for both therapies is > 70%. Aim: To report the experience with SCT and ATG for AA in a public hospital. Patients and Methods: AA was diagnosed in 42 patients between 1998 and 2016, according to Camitta criteria. Thirty eight (90%) received treatment, 7 (18%) under 40 years old received SCT, and 31 (82%) IST. The rest were not treated. OS was calculated from date of diagnosis until last control, death or loss from follow up. Results: Complete or partial hematologic response, was obtained in 71% and 58% of cases with SCT and IS, respectively. Five year OS was 71% and 55% with SCT and IST, respectively. No difference in response was observed between horse and rabbit ATG. Conclusions: SCT from an HLA-identical sibling donor had a high response rate and survival. IST instead, had a lower response and survival, due to an initial high mortality rate.
author	León,Pilar Cardemil,Daniela Osorio,Rocío Peña,Camila Valladares,Ximena Puga,Bárbara Cabrera,María Elena
author_facet	León,Pilar Cardemil,Daniela Osorio,Rocío Peña,Camila Valladares,Ximena Puga,Bárbara Cabrera,María Elena
author_sort	León,Pilar
title	Aplasia medular adquirida, experiencia en un hospital público de referencia
title_short	Aplasia medular adquirida, experiencia en un hospital público de referencia
title_full	Aplasia medular adquirida, experiencia en un hospital público de referencia
title_fullStr	Aplasia medular adquirida, experiencia en un hospital público de referencia
title_full_unstemmed	Aplasia medular adquirida, experiencia en un hospital público de referencia
title_sort	aplasia medular adquirida, experiencia en un hospital público de referencia
publisher	Sociedad Médica de Santiago
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000200175
work_keys_str_mv	AT leonpilar aplasiamedularadquiridaexperienciaenunhospitalpublicodereferencia AT cardemildaniela aplasiamedularadquiridaexperienciaenunhospitalpublicodereferencia AT osoriorocio aplasiamedularadquiridaexperienciaenunhospitalpublicodereferencia AT penacamila aplasiamedularadquiridaexperienciaenunhospitalpublicodereferencia AT valladaresximena aplasiamedularadquiridaexperienciaenunhospitalpublicodereferencia AT pugabarbara aplasiamedularadquiridaexperienciaenunhospitalpublicodereferencia AT cabreramariaelena aplasiamedularadquiridaexperienciaenunhospitalpublicodereferencia
_version_	1718436989812867072

Aplasia medular adquirida, experiencia en un hospital público de referencia

Ejemplares similares