Evolución de mortalidad, abandono, traslado y retención a corto, mediano y largo plazo en pacientes con infección por VIH: Fundación Arriarán 1990-2015

Background: The HIV epidemic reached Chile in late 1980s and as an early response, AIDS care centers were organized. Fundación Arriarán (FA) was the first center. Free antiretroviral therapy (ART) was later provided with progressive coverage and complexity over the years. Aim: To quantify evolutio...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Cortés,Claudia P., Lizana,Danae, Northland,Rebeca, Wolff R.,Marcelo
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2018
Materias:	Cohort Studies HIV Lost to Follow-Up Mortality Survival
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000300290
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0034-98872018000300290
record_format	dspace
spelling	oai:scielo:S0034-988720180003002902018-06-20Evolución de mortalidad, abandono, traslado y retención a corto, mediano y largo plazo en pacientes con infección por VIH: Fundación Arriarán 1990-2015Cortés,Claudia P.Lizana,DanaeNorthland,RebecaWolff R.,Marcelo Cohort Studies HIV Lost to Follow-Up Mortality Survival Background: The HIV epidemic reached Chile in late 1980s and as an early response, AIDS care centers were organized. Fundación Arriarán (FA) was the first center. Free antiretroviral therapy (ART) was later provided with progressive coverage and complexity over the years. Aim: To quantify evolution of mortality, retention and loss to follow up (LTFU) over 25 years according to different periods of access to ART, from no availability to full coverage with current drugs at FA center. Material and Methods: Retrospective analysis of FA database of 5,080 adults admitted between 1990 and 2014. The sample was distributed in 7 groups: A: no ART (1990-92), B: monotherapy, C: dual therapy, D: dual/triple ART, E: early triple therapy with incomplete coverage, F same as E but with complete coverage and G: contemporary ART (2008-14). Mortality, retention and LTFU were evaluated at 1, 3, 5, 7 and 10 years and at 31/12/2015. Results: Mortality varied from 40% to 2%, and 62% to 7% at 1 and 5 years, for groups A and G respectively; from 71% to 16% at 10 years for groups A and E, respectively. Retention at 5 years were 28%, 23%, 39%, 62%, 75%, 75% and 77% for groups A to G, respectively. LTFU was 10%, 19%, 15%, 17%, 9% 12% and 10% at 5 years for same groups, respectively. At 12/31/2015 22% of patients had died, 11% were LTFU, 60% were retained in care and 6% had been transferred. Conclusions: There is a marked reduction in mortality and increase in retention of HIV patients’ concomitant to expanded access to modern therapy, although LTFU remains a problem.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.146 n.3 20182018-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000300290es10.4067/s0034-98872018000300290
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Cohort Studies HIV Lost to Follow-Up Mortality Survival
spellingShingle	Cohort Studies HIV Lost to Follow-Up Mortality Survival Cortés,Claudia P. Lizana,Danae Northland,Rebeca Wolff R.,Marcelo Evolución de mortalidad, abandono, traslado y retención a corto, mediano y largo plazo en pacientes con infección por VIH: Fundación Arriarán 1990-2015
description	Background: The HIV epidemic reached Chile in late 1980s and as an early response, AIDS care centers were organized. Fundación Arriarán (FA) was the first center. Free antiretroviral therapy (ART) was later provided with progressive coverage and complexity over the years. Aim: To quantify evolution of mortality, retention and loss to follow up (LTFU) over 25 years according to different periods of access to ART, from no availability to full coverage with current drugs at FA center. Material and Methods: Retrospective analysis of FA database of 5,080 adults admitted between 1990 and 2014. The sample was distributed in 7 groups: A: no ART (1990-92), B: monotherapy, C: dual therapy, D: dual/triple ART, E: early triple therapy with incomplete coverage, F same as E but with complete coverage and G: contemporary ART (2008-14). Mortality, retention and LTFU were evaluated at 1, 3, 5, 7 and 10 years and at 31/12/2015. Results: Mortality varied from 40% to 2%, and 62% to 7% at 1 and 5 years, for groups A and G respectively; from 71% to 16% at 10 years for groups A and E, respectively. Retention at 5 years were 28%, 23%, 39%, 62%, 75%, 75% and 77% for groups A to G, respectively. LTFU was 10%, 19%, 15%, 17%, 9% 12% and 10% at 5 years for same groups, respectively. At 12/31/2015 22% of patients had died, 11% were LTFU, 60% were retained in care and 6% had been transferred. Conclusions: There is a marked reduction in mortality and increase in retention of HIV patients’ concomitant to expanded access to modern therapy, although LTFU remains a problem.
author	Cortés,Claudia P. Lizana,Danae Northland,Rebeca Wolff R.,Marcelo
author_facet	Cortés,Claudia P. Lizana,Danae Northland,Rebeca Wolff R.,Marcelo
author_sort	Cortés,Claudia P.
title	Evolución de mortalidad, abandono, traslado y retención a corto, mediano y largo plazo en pacientes con infección por VIH: Fundación Arriarán 1990-2015
title_short	Evolución de mortalidad, abandono, traslado y retención a corto, mediano y largo plazo en pacientes con infección por VIH: Fundación Arriarán 1990-2015
title_full	Evolución de mortalidad, abandono, traslado y retención a corto, mediano y largo plazo en pacientes con infección por VIH: Fundación Arriarán 1990-2015
title_fullStr	Evolución de mortalidad, abandono, traslado y retención a corto, mediano y largo plazo en pacientes con infección por VIH: Fundación Arriarán 1990-2015
title_full_unstemmed	Evolución de mortalidad, abandono, traslado y retención a corto, mediano y largo plazo en pacientes con infección por VIH: Fundación Arriarán 1990-2015
title_sort	evolución de mortalidad, abandono, traslado y retención a corto, mediano y largo plazo en pacientes con infección por vih: fundación arriarán 1990-2015
publisher	Sociedad Médica de Santiago
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000300290
work_keys_str_mv	AT cortesclaudiap evoluciondemortalidadabandonotrasladoyretencionacortomedianoylargoplazoenpacientesconinfeccionporvihfundacionarriaran19902015 AT lizanadanae evoluciondemortalidadabandonotrasladoyretencionacortomedianoylargoplazoenpacientesconinfeccionporvihfundacionarriaran19902015 AT northlandrebeca evoluciondemortalidadabandonotrasladoyretencionacortomedianoylargoplazoenpacientesconinfeccionporvihfundacionarriaran19902015 AT wolffrmarcelo evoluciondemortalidadabandonotrasladoyretencionacortomedianoylargoplazoenpacientesconinfeccionporvihfundacionarriaran19902015
_version_	1718436994243100672

Evolución de mortalidad, abandono, traslado y retención a corto, mediano y largo plazo en pacientes con infección por VIH: Fundación Arriarán 1990-2015

Ejemplares similares