Desensibilización a levotiroxina. Caso clínico

We report a 39-year-old female who underwent a total thyroidectomy as treatment for a thyroid papillary cancer. She suffered several episodes of mild angioedema in lips and tongue, after using different commercial Levothyroxine formulations, with and without excipients. Given the need to use this dr...

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Autores principales:	Guzmán,María Antonieta, Sepúlveda,Cecilia, Liberman,Claudio, Cornejo,Rodrigo, Roizen,Gigia, Cereceda,Daniela, Lara,María Fernanda, Álvarez-Cuesta,Emilio
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2018
Materias:	Drug Hypersensitivity Hypersensitivity Thyroxine
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000300394
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id	oai:scielo:S0034-98872018000300394
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spelling	oai:scielo:S0034-988720180003003942018-06-20Desensibilización a levotiroxina. Caso clínicoGuzmán,María AntonietaSepúlveda,CeciliaLiberman,ClaudioCornejo,RodrigoRoizen,GigiaCereceda,DanielaLara,María FernandaÁlvarez-Cuesta,Emilio Drug Hypersensitivity Hypersensitivity Thyroxine We report a 39-year-old female who underwent a total thyroidectomy as treatment for a thyroid papillary cancer. She suffered several episodes of mild angioedema in lips and tongue, after using different commercial Levothyroxine formulations, with and without excipients. Given the need to use this drug, the patient was admitted in our hospital and we proceeded to desensitize her with oral Levothyroxine. The patient fasted throughout the whole procedure, was properly monitored and had an adequate peripheral venous access. On the first day of the procedure, a 15-step protocol was performed, first administering placebo and then, compounded formulations of Levothyroxine starting from 0.01 ug, followed by doubling doses every 15 minutes until the cumulative dose of 111.95 ug was completed, corresponding to the daily dose of Levothyroxine her endocrinologist prescribed (112 ug). The patient was monitored at baseline, between each dose and up to 3 hours after the procedure was completed. There were no incidents such as urticaria, angioedema, or others. On the second day, the patient received a single-full dose of 112 ug on an empty stomach. The medication was successfully tolerated and she was discharged. Thereafter, she tolerates daily Levothyroxine.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.146 n.3 20182018-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000300394es10.4067/s0034-98872018000300394
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Drug Hypersensitivity Hypersensitivity Thyroxine
spellingShingle	Drug Hypersensitivity Hypersensitivity Thyroxine Guzmán,María Antonieta Sepúlveda,Cecilia Liberman,Claudio Cornejo,Rodrigo Roizen,Gigia Cereceda,Daniela Lara,María Fernanda Álvarez-Cuesta,Emilio Desensibilización a levotiroxina. Caso clínico
description	We report a 39-year-old female who underwent a total thyroidectomy as treatment for a thyroid papillary cancer. She suffered several episodes of mild angioedema in lips and tongue, after using different commercial Levothyroxine formulations, with and without excipients. Given the need to use this drug, the patient was admitted in our hospital and we proceeded to desensitize her with oral Levothyroxine. The patient fasted throughout the whole procedure, was properly monitored and had an adequate peripheral venous access. On the first day of the procedure, a 15-step protocol was performed, first administering placebo and then, compounded formulations of Levothyroxine starting from 0.01 ug, followed by doubling doses every 15 minutes until the cumulative dose of 111.95 ug was completed, corresponding to the daily dose of Levothyroxine her endocrinologist prescribed (112 ug). The patient was monitored at baseline, between each dose and up to 3 hours after the procedure was completed. There were no incidents such as urticaria, angioedema, or others. On the second day, the patient received a single-full dose of 112 ug on an empty stomach. The medication was successfully tolerated and she was discharged. Thereafter, she tolerates daily Levothyroxine.
author	Guzmán,María Antonieta Sepúlveda,Cecilia Liberman,Claudio Cornejo,Rodrigo Roizen,Gigia Cereceda,Daniela Lara,María Fernanda Álvarez-Cuesta,Emilio
author_facet	Guzmán,María Antonieta Sepúlveda,Cecilia Liberman,Claudio Cornejo,Rodrigo Roizen,Gigia Cereceda,Daniela Lara,María Fernanda Álvarez-Cuesta,Emilio
author_sort	Guzmán,María Antonieta
title	Desensibilización a levotiroxina. Caso clínico
title_short	Desensibilización a levotiroxina. Caso clínico
title_full	Desensibilización a levotiroxina. Caso clínico
title_fullStr	Desensibilización a levotiroxina. Caso clínico
title_full_unstemmed	Desensibilización a levotiroxina. Caso clínico
title_sort	desensibilización a levotiroxina. caso clínico
publisher	Sociedad Médica de Santiago
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000300394
work_keys_str_mv	AT guzmanmariaantonieta desensibilizacionalevotiroxinacasoclinico AT sepulvedacecilia desensibilizacionalevotiroxinacasoclinico AT libermanclaudio desensibilizacionalevotiroxinacasoclinico AT cornejorodrigo desensibilizacionalevotiroxinacasoclinico AT roizengigia desensibilizacionalevotiroxinacasoclinico AT cerecedadaniela desensibilizacionalevotiroxinacasoclinico AT laramariafernanda desensibilizacionalevotiroxinacasoclinico AT alvarezcuestaemilio desensibilizacionalevotiroxinacasoclinico
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Desensibilización a levotiroxina. Caso clínico

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