Hiperglicemia por sepsis: del mecanismo a la clínica

Stress hyperglycemia is frequently diagnosed in septic patients in critical care units (ICU) and it is associated with greater illness severity and higher morbimortality rates. In response to an acute injury, high levels of counterregulatory hormones such as glucocorticoids and catecholamines are re...

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Autores principales:	Aleman,Larissa, Guerrero,Julia
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2018
Materias:	Critical Illness Hyperglycemia Intensive Care Units
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000400502
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spelling	oai:scielo:S0034-988720180004005022018-07-03Hiperglicemia por sepsis: del mecanismo a la clínicaAleman,LarissaGuerrero,Julia Critical Illness Hyperglycemia Intensive Care Units Stress hyperglycemia is frequently diagnosed in septic patients in critical care units (ICU) and it is associated with greater illness severity and higher morbimortality rates. In response to an acute injury, high levels of counterregulatory hormones such as glucocorticoids and catecholamines are released causing increased hepatic gluconeogenesis and insulin resistance. Furthermore, during sepsis, proinflammatory cytokines also participate in the pathogenesis of this phenomenon. Septic patients represent a subtype of the critical ill patients in the ICU: this metabolic disarrangement management strategies and insulin therapy recommendations had been inconsistent. In this article, we describe the pathophysiological mechanisms of stress hyperglycemia in critical patients including the action of hormones, inflammatory cytokines and tissue resistance to insulin. In addition, we analyzed the main published studies for the treatment of acute hyperglycemia in critical patients.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.146 n.4 20182018-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000400502es10.4067/s0034-98872018000400502
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Critical Illness Hyperglycemia Intensive Care Units
spellingShingle	Critical Illness Hyperglycemia Intensive Care Units Aleman,Larissa Guerrero,Julia Hiperglicemia por sepsis: del mecanismo a la clínica
description	Stress hyperglycemia is frequently diagnosed in septic patients in critical care units (ICU) and it is associated with greater illness severity and higher morbimortality rates. In response to an acute injury, high levels of counterregulatory hormones such as glucocorticoids and catecholamines are released causing increased hepatic gluconeogenesis and insulin resistance. Furthermore, during sepsis, proinflammatory cytokines also participate in the pathogenesis of this phenomenon. Septic patients represent a subtype of the critical ill patients in the ICU: this metabolic disarrangement management strategies and insulin therapy recommendations had been inconsistent. In this article, we describe the pathophysiological mechanisms of stress hyperglycemia in critical patients including the action of hormones, inflammatory cytokines and tissue resistance to insulin. In addition, we analyzed the main published studies for the treatment of acute hyperglycemia in critical patients.
author	Aleman,Larissa Guerrero,Julia
author_facet	Aleman,Larissa Guerrero,Julia
author_sort	Aleman,Larissa
title	Hiperglicemia por sepsis: del mecanismo a la clínica
title_short	Hiperglicemia por sepsis: del mecanismo a la clínica
title_full	Hiperglicemia por sepsis: del mecanismo a la clínica
title_fullStr	Hiperglicemia por sepsis: del mecanismo a la clínica
title_full_unstemmed	Hiperglicemia por sepsis: del mecanismo a la clínica
title_sort	hiperglicemia por sepsis: del mecanismo a la clínica
publisher	Sociedad Médica de Santiago
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000400502
work_keys_str_mv	AT alemanlarissa hiperglicemiaporsepsisdelmecanismoalaclinica AT guerrerojulia hiperglicemiaporsepsisdelmecanismoalaclinica
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Hiperglicemia por sepsis: del mecanismo a la clínica

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