Necrolisis epidérmica tóxica en el curso de un síndrome hemofagocítico secundario a linfoma de Hodgkin. Caso clínico

Toxic epidermal necrolysis (TEN) is a lethal entity, characterized by extensive epidermal necrosis and multiorgan failure. Hemophagocytic syndrome (HFS) is also a rare and lethal syndrome characterized by hyperinflammation that leads to the appearance of fever, pancytopenia, organomegaly and hemopha...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Peña,Camila, Voisin,Javier, González,José Tomás, Villegas,Pablo
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2018
Materias:	Hodgkin Disease Lymphohistiocytosis Hemophagocytic Stevesns-Johnson Syndrome
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000400523
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0034-98872018000400523
record_format	dspace
spelling	oai:scielo:S0034-988720180004005232018-07-03Necrolisis epidérmica tóxica en el curso de un síndrome hemofagocítico secundario a linfoma de Hodgkin. Caso clínicoPeña,CamilaVoisin,JavierGonzález,José TomásVillegas,Pablo Hodgkin Disease Lymphohistiocytosis Hemophagocytic Stevesns-Johnson Syndrome Toxic epidermal necrolysis (TEN) is a lethal entity, characterized by extensive epidermal necrosis and multiorgan failure. Hemophagocytic syndrome (HFS) is also a rare and lethal syndrome characterized by hyperinflammation that leads to the appearance of fever, pancytopenia, organomegaly and hemophagocytosis. The concomitance of these diseases is extremely uncommon. We report a 38 years old female, who during the course of a HFS secondary to Hodgkin Lymphoma (HL), presented a TEN secondary to antibiotics. She was admitted due to a consumptive syndrome, lymphadenopathy, visceromegaly and severe pancytopenia. Laboratory and bone marrow tests confirmed HFS. Due to constant fever, imipenem was indicated. On the third day she started with pain and skin rash. She evolved with positive Nikolsky sign. Cutaneous biopsy was concordant with extensive TEN, which was managed with intravenous immunoglobulin and dexamethasone. A complete response and normalization of the blood count were achieved. Finally, the lymph node biopsy showed HL of mixed cellularity type, which was managed with 8 cycles of ABVD chemotherapy, achieving complete remission.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.146 n.4 20182018-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000400523es10.4067/s0034-98872018000400523
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Hodgkin Disease Lymphohistiocytosis Hemophagocytic Stevesns-Johnson Syndrome
spellingShingle	Hodgkin Disease Lymphohistiocytosis Hemophagocytic Stevesns-Johnson Syndrome Peña,Camila Voisin,Javier González,José Tomás Villegas,Pablo Necrolisis epidérmica tóxica en el curso de un síndrome hemofagocítico secundario a linfoma de Hodgkin. Caso clínico
description	Toxic epidermal necrolysis (TEN) is a lethal entity, characterized by extensive epidermal necrosis and multiorgan failure. Hemophagocytic syndrome (HFS) is also a rare and lethal syndrome characterized by hyperinflammation that leads to the appearance of fever, pancytopenia, organomegaly and hemophagocytosis. The concomitance of these diseases is extremely uncommon. We report a 38 years old female, who during the course of a HFS secondary to Hodgkin Lymphoma (HL), presented a TEN secondary to antibiotics. She was admitted due to a consumptive syndrome, lymphadenopathy, visceromegaly and severe pancytopenia. Laboratory and bone marrow tests confirmed HFS. Due to constant fever, imipenem was indicated. On the third day she started with pain and skin rash. She evolved with positive Nikolsky sign. Cutaneous biopsy was concordant with extensive TEN, which was managed with intravenous immunoglobulin and dexamethasone. A complete response and normalization of the blood count were achieved. Finally, the lymph node biopsy showed HL of mixed cellularity type, which was managed with 8 cycles of ABVD chemotherapy, achieving complete remission.
author	Peña,Camila Voisin,Javier González,José Tomás Villegas,Pablo
author_facet	Peña,Camila Voisin,Javier González,José Tomás Villegas,Pablo
author_sort	Peña,Camila
title	Necrolisis epidérmica tóxica en el curso de un síndrome hemofagocítico secundario a linfoma de Hodgkin. Caso clínico
title_short	Necrolisis epidérmica tóxica en el curso de un síndrome hemofagocítico secundario a linfoma de Hodgkin. Caso clínico
title_full	Necrolisis epidérmica tóxica en el curso de un síndrome hemofagocítico secundario a linfoma de Hodgkin. Caso clínico
title_fullStr	Necrolisis epidérmica tóxica en el curso de un síndrome hemofagocítico secundario a linfoma de Hodgkin. Caso clínico
title_full_unstemmed	Necrolisis epidérmica tóxica en el curso de un síndrome hemofagocítico secundario a linfoma de Hodgkin. Caso clínico
title_sort	necrolisis epidérmica tóxica en el curso de un síndrome hemofagocítico secundario a linfoma de hodgkin. caso clínico
publisher	Sociedad Médica de Santiago
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000400523
work_keys_str_mv	AT penacamila necrolisisepidermicatoxicaenelcursodeunsindromehemofagociticosecundarioalinfomadehodgkincasoclinico AT voisinjavier necrolisisepidermicatoxicaenelcursodeunsindromehemofagociticosecundarioalinfomadehodgkincasoclinico AT gonzalezjosetomas necrolisisepidermicatoxicaenelcursodeunsindromehemofagociticosecundarioalinfomadehodgkincasoclinico AT villegaspablo necrolisisepidermicatoxicaenelcursodeunsindromehemofagociticosecundarioalinfomadehodgkincasoclinico
_version_	1718437002592911360

Necrolisis epidérmica tóxica en el curso de un síndrome hemofagocítico secundario a linfoma de Hodgkin. Caso clínico

Ejemplares similares