Disminución en la frecuencia de infección por Helicobacter pylori en endoscopías digestivas altas

Background: Helicobacter pylori (HP) is the most widespread chronic human infection worldwide and the most important pathogenic factor of gastric cancer. The calculated prevalence at the Clinical Hospital of the University of Chile from 2002 to 2005 was 44.9%. Aim: To determine the current prevale...

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Autores principales:	Da Costa,Daniel, Guidotti,Francesca, Cabello,Nicolas, Trigo,Francisco, Contreras,Caterina, Vergara,Francisca, Miranda,Juan Pablo, Montenegro,Cristián, Muñoz,Pablo, Berger,Zoltán
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2018
Materias:	Endoscopy Gastrointestinal Helicobacter pylori Prevalence Upper Gastrointestinal Tract Urease
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000500555
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spelling	oai:scielo:S0034-988720180005005552018-07-26Disminución en la frecuencia de infección por Helicobacter pylori en endoscopías digestivas altasDa Costa,DanielGuidotti,FrancescaCabello,NicolasTrigo,FranciscoContreras,CaterinaVergara,FranciscaMiranda,Juan PabloMontenegro,CristiánMuñoz,PabloBerger,Zoltán Endoscopy Gastrointestinal Helicobacter pylori Prevalence Upper Gastrointestinal Tract Urease Background: Helicobacter pylori (HP) is the most widespread chronic human infection worldwide and the most important pathogenic factor of gastric cancer. The calculated prevalence at the Clinical Hospital of the University of Chile from 2002 to 2005 was 44.9%. Aim: To determine the current prevalence of HP in patients undergoing an upper gastrointestinal endoscopy (UGI) and analyze its distribution according to age and endoscopic findings. Material and Methods: We reviewed 3.433 UGI performed during the year 2015, selecting those in which rapid urease test (RUT) was done. A positive RUT or a positive gastric biopsy (GB) were considered as HP infection. Results: RUT was done in 1862 UGI (55%) performed in patients aged 51 ± 17 years, (66% women). In 23% of these endoscopies, the RUT was positive. A GB was obtained 43% of endoscopies and 30% were positive for HP. In 105 patients the RUT was negative and the GB positive (rendering a 19.5% false negative rate). HP was detected by RUT and GB in 29% of endoscopies. The highest prevalence of infection (38.1%) was found between 40 and 49 years. HP infection had odds ratio of 4.24 for nodular gastropathy, 2.63 for gastric ulcer and 2.14 for duodenal ulcer (p < 0.05). Conclusions: HP prevalence in our center decreased significantly from 44.9% to 28.9% in 11 years. False negative RUT results may bias this finding. The use of proton pump inhibitors and antimicrobials that can interfere with the detection of HP should be registered to properly analyze the results of the RUT.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.146 n.5 20182018-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000500555es10.4067/s0034-98872018000500555
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Endoscopy Gastrointestinal Helicobacter pylori Prevalence Upper Gastrointestinal Tract Urease
spellingShingle	Endoscopy Gastrointestinal Helicobacter pylori Prevalence Upper Gastrointestinal Tract Urease Da Costa,Daniel Guidotti,Francesca Cabello,Nicolas Trigo,Francisco Contreras,Caterina Vergara,Francisca Miranda,Juan Pablo Montenegro,Cristián Muñoz,Pablo Berger,Zoltán Disminución en la frecuencia de infección por Helicobacter pylori en endoscopías digestivas altas
description	Background: Helicobacter pylori (HP) is the most widespread chronic human infection worldwide and the most important pathogenic factor of gastric cancer. The calculated prevalence at the Clinical Hospital of the University of Chile from 2002 to 2005 was 44.9%. Aim: To determine the current prevalence of HP in patients undergoing an upper gastrointestinal endoscopy (UGI) and analyze its distribution according to age and endoscopic findings. Material and Methods: We reviewed 3.433 UGI performed during the year 2015, selecting those in which rapid urease test (RUT) was done. A positive RUT or a positive gastric biopsy (GB) were considered as HP infection. Results: RUT was done in 1862 UGI (55%) performed in patients aged 51 ± 17 years, (66% women). In 23% of these endoscopies, the RUT was positive. A GB was obtained 43% of endoscopies and 30% were positive for HP. In 105 patients the RUT was negative and the GB positive (rendering a 19.5% false negative rate). HP was detected by RUT and GB in 29% of endoscopies. The highest prevalence of infection (38.1%) was found between 40 and 49 years. HP infection had odds ratio of 4.24 for nodular gastropathy, 2.63 for gastric ulcer and 2.14 for duodenal ulcer (p < 0.05). Conclusions: HP prevalence in our center decreased significantly from 44.9% to 28.9% in 11 years. False negative RUT results may bias this finding. The use of proton pump inhibitors and antimicrobials that can interfere with the detection of HP should be registered to properly analyze the results of the RUT.
author	Da Costa,Daniel Guidotti,Francesca Cabello,Nicolas Trigo,Francisco Contreras,Caterina Vergara,Francisca Miranda,Juan Pablo Montenegro,Cristián Muñoz,Pablo Berger,Zoltán
author_facet	Da Costa,Daniel Guidotti,Francesca Cabello,Nicolas Trigo,Francisco Contreras,Caterina Vergara,Francisca Miranda,Juan Pablo Montenegro,Cristián Muñoz,Pablo Berger,Zoltán
author_sort	Da Costa,Daniel
title	Disminución en la frecuencia de infección por Helicobacter pylori en endoscopías digestivas altas
title_short	Disminución en la frecuencia de infección por Helicobacter pylori en endoscopías digestivas altas
title_full	Disminución en la frecuencia de infección por Helicobacter pylori en endoscopías digestivas altas
title_fullStr	Disminución en la frecuencia de infección por Helicobacter pylori en endoscopías digestivas altas
title_full_unstemmed	Disminución en la frecuencia de infección por Helicobacter pylori en endoscopías digestivas altas
title_sort	disminución en la frecuencia de infección por helicobacter pylori en endoscopías digestivas altas
publisher	Sociedad Médica de Santiago
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000500555
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Disminución en la frecuencia de infección por Helicobacter pylori en endoscopías digestivas altas

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