Estimulación cerebral profunda en enfermedad de Parkinson

Estimulación cerebral profunda en enfermedad de Parkinson

Background: Deep brain stimulation is an essential therapeutic tool in Parkinson's disease. Aim: To assess the results of a series of patients with Parkinson's disease treated with micro-electrode guided subthalamic nucleus stimulation. Material and Methods: Twenty patients with idiopat...

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Autores principales: Kunstmann,Carolina, Valdivia,Felipe, De Marinis,Alejandro, Ayach,Fredy, Montes,José Miguel, Chana-Cuevas,Pedro
Lenguaje:Spanish / Castilian
Publicado: Sociedad Médica de Santiago 2018
Materias:
Deep Brain Stimulation
Parkinson Disease
Subthalamic Nucleus
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000500562
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spelling oai:scielo:S0034-988720180005005622018-07-26Estimulación cerebral profunda en enfermedad de ParkinsonKunstmann,CarolinaValdivia,FelipeDe Marinis,AlejandroAyach,FredyMontes,José MiguelChana-Cuevas,Pedro Deep Brain Stimulation Parkinson Disease Subthalamic Nucleus Background: Deep brain stimulation is an essential therapeutic tool in Parkinson's disease. Aim: To assess the results of a series of patients with Parkinson's disease treated with micro-electrode guided subthalamic nucleus stimulation. Material and Methods: Twenty patients with idiopathic Parkinson's disease were studied (10 males). Three months after surgery, we analyzed the change in motor disturbances, medication need to control symptoms and quality of life. Results: We observed a significant improvement in all the assessed variables. Motor involvement determined as OFF hours and expressed as percentage of the day changed from 30 ± 15 to 10 ± 7% in the preoperative and postoperative periods, respectively. ON hours without dyskinesia changed from 17 ± 16 to 78 ± 21%. ON hours with dyskinesia changed from 53 ± 23 to 12 ± 15%. Medication need changed from 1,505 ± 499 to 1,214 ± 528 levodopa equivalents. Parkinson's Disease Questionnaire 39 score changed from 62.9 ± 22.7 to 34.3 ± 18.5. During the 5-year follow-up a continuous improvement of symptoms was observed. Conclusions: Micro-electrode guided subthalamic nucleus functional surgery in patients with Parkinson's disease has good immediate and late results.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.146 n.5 20182018-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000500562es10.4067/s0034-98872018000500562
institution Scielo Chile
collection Scielo Chile
language Spanish / Castilian
topic Deep Brain Stimulation
Parkinson Disease
Subthalamic Nucleus
spellingShingle Deep Brain Stimulation
Parkinson Disease
Subthalamic Nucleus
Kunstmann,Carolina
Valdivia,Felipe
De Marinis,Alejandro
Ayach,Fredy
Montes,José Miguel
Chana-Cuevas,Pedro
Estimulación cerebral profunda en enfermedad de Parkinson
description Background: Deep brain stimulation is an essential therapeutic tool in Parkinson's disease. Aim: To assess the results of a series of patients with Parkinson's disease treated with micro-electrode guided subthalamic nucleus stimulation. Material and Methods: Twenty patients with idiopathic Parkinson's disease were studied (10 males). Three months after surgery, we analyzed the change in motor disturbances, medication need to control symptoms and quality of life. Results: We observed a significant improvement in all the assessed variables. Motor involvement determined as OFF hours and expressed as percentage of the day changed from 30 ± 15 to 10 ± 7% in the preoperative and postoperative periods, respectively. ON hours without dyskinesia changed from 17 ± 16 to 78 ± 21%. ON hours with dyskinesia changed from 53 ± 23 to 12 ± 15%. Medication need changed from 1,505 ± 499 to 1,214 ± 528 levodopa equivalents. Parkinson's Disease Questionnaire 39 score changed from 62.9 ± 22.7 to 34.3 ± 18.5. During the 5-year follow-up a continuous improvement of symptoms was observed. Conclusions: Micro-electrode guided subthalamic nucleus functional surgery in patients with Parkinson's disease has good immediate and late results.
author Kunstmann,Carolina
Valdivia,Felipe
De Marinis,Alejandro
Ayach,Fredy
Montes,José Miguel
Chana-Cuevas,Pedro
author_facet Kunstmann,Carolina
Valdivia,Felipe
De Marinis,Alejandro
Ayach,Fredy
Montes,José Miguel
Chana-Cuevas,Pedro
author_sort Kunstmann,Carolina
title Estimulación cerebral profunda en enfermedad de Parkinson
title_short Estimulación cerebral profunda en enfermedad de Parkinson
title_full Estimulación cerebral profunda en enfermedad de Parkinson
title_fullStr Estimulación cerebral profunda en enfermedad de Parkinson
title_full_unstemmed Estimulación cerebral profunda en enfermedad de Parkinson
title_sort estimulación cerebral profunda en enfermedad de parkinson
publisher Sociedad Médica de Santiago
publishDate 2018
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000500562
work_keys_str_mv AT kunstmanncarolina estimulacioncerebralprofundaenenfermedaddeparkinson
AT valdiviafelipe estimulacioncerebralprofundaenenfermedaddeparkinson
AT demarinisalejandro estimulacioncerebralprofundaenenfermedaddeparkinson
AT ayachfredy estimulacioncerebralprofundaenenfermedaddeparkinson
AT montesjosemiguel estimulacioncerebralprofundaenenfermedaddeparkinson
AT chanacuevaspedro estimulacioncerebralprofundaenenfermedaddeparkinson
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