Asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena

Asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena

Background: Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity. Aim: To investigate the association of FTO gene with adiposity markers in Chilean adults. Material and Methods: 409 participants were included in this cross-sectional study. The...

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Autores principales: Petermann,Fanny, Villagrán,Marcelo, Troncoso,Claudia, Mardones,Lorena, Leiva,Ana María, Martínez,María Adela, Garrido-Méndez,Alex, Poblete-Valderrama,Felipe, Salas-Bravo,Carlos, Ramírez-Vélez,Robinson, Ulloa,Natalia, Pérez-Bravo,Francisco, Celis-Morales,Carlos
Lenguaje:Spanish / Castilian
Publicado: Sociedad Médica de Santiago 2018
Materias:
Adiposity
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Genotype
Obesity
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000600717
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spelling oai:scielo:S0034-988720180006007172018-08-24Asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilenaPetermann,FannyVillagrán,MarceloTroncoso,ClaudiaMardones,LorenaLeiva,Ana MaríaMartínez,María AdelaGarrido-Méndez,AlexPoblete-Valderrama,FelipeSalas-Bravo,CarlosRamírez-Vélez,RobinsonUlloa,NataliaPérez-Bravo,FranciscoCelis-Morales,Carlos Adiposity Alpha-Ketoglutarate-Dependent Dioxygenase FTO Genotype Obesity Background: Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity. Aim: To investigate the association of FTO gene with adiposity markers in Chilean adults. Material and Methods: 409 participants were included in this cross-sectional study. The association between FTO (rs9939609) genotype and adiposity markers was determined using linear regression analyses. Adiposity markers included were: body weight, body mass index, fat mass, waist circumference, hip circumference and waist/hip ratio. Results: A fully adjusted model showed a significant association between FTO genotype and body weight (2.16 kg per each extra copy of the risk allele [95% confidence intervals (CI): 0.45 to 3.87], p = 0.014), body mass index (0.61 kg.m-2 [95% CI: 0.12 to 1.20], p = 0.050) and fat mass (1.14% [95% CI: 0.39 to 1.89], p = 0.010). The greater magnitude of association was found between the FTO gene and fat mass when the outcomes were standardized to z-score. Conclusions: This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.146 n.6 20182018-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000600717es10.4067/s0034-98872018000600717
institution Scielo Chile
collection Scielo Chile
language Spanish / Castilian
topic Adiposity
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Genotype
Obesity
spellingShingle Adiposity
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Genotype
Obesity
Petermann,Fanny
Villagrán,Marcelo
Troncoso,Claudia
Mardones,Lorena
Leiva,Ana María
Martínez,María Adela
Garrido-Méndez,Alex
Poblete-Valderrama,Felipe
Salas-Bravo,Carlos
Ramírez-Vélez,Robinson
Ulloa,Natalia
Pérez-Bravo,Francisco
Celis-Morales,Carlos
Asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena
description Background: Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity. Aim: To investigate the association of FTO gene with adiposity markers in Chilean adults. Material and Methods: 409 participants were included in this cross-sectional study. The association between FTO (rs9939609) genotype and adiposity markers was determined using linear regression analyses. Adiposity markers included were: body weight, body mass index, fat mass, waist circumference, hip circumference and waist/hip ratio. Results: A fully adjusted model showed a significant association between FTO genotype and body weight (2.16 kg per each extra copy of the risk allele [95% confidence intervals (CI): 0.45 to 3.87], p = 0.014), body mass index (0.61 kg.m-2 [95% CI: 0.12 to 1.20], p = 0.050) and fat mass (1.14% [95% CI: 0.39 to 1.89], p = 0.010). The greater magnitude of association was found between the FTO gene and fat mass when the outcomes were standardized to z-score. Conclusions: This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors.
author Petermann,Fanny
Villagrán,Marcelo
Troncoso,Claudia
Mardones,Lorena
Leiva,Ana María
Martínez,María Adela
Garrido-Méndez,Alex
Poblete-Valderrama,Felipe
Salas-Bravo,Carlos
Ramírez-Vélez,Robinson
Ulloa,Natalia
Pérez-Bravo,Francisco
Celis-Morales,Carlos
author_facet Petermann,Fanny
Villagrán,Marcelo
Troncoso,Claudia
Mardones,Lorena
Leiva,Ana María
Martínez,María Adela
Garrido-Méndez,Alex
Poblete-Valderrama,Felipe
Salas-Bravo,Carlos
Ramírez-Vélez,Robinson
Ulloa,Natalia
Pérez-Bravo,Francisco
Celis-Morales,Carlos
author_sort Petermann,Fanny
title Asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena
title_short Asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena
title_full Asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena
title_fullStr Asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena
title_full_unstemmed Asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena
title_sort asociación entre el polimorfismo rs9939609 del gen fto y marcadores de adiposidad en población adulta chilena
publisher Sociedad Médica de Santiago
publishDate 2018
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000600717
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