Combatiendo el metabolismo de las células cancerosas mediante la activación de SIRT3 y el ejercicio físico

One of the main features of cancer is the high rate of cell proliferation and growth. To do this, cancer cells need to redirect their metabolism mainly towards anaerobic glycolysis and an increased mitochondrial glutamine energy metabolism. Sirtuins are cellular proteins with regulatory functions on...

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Autores principales:	Bórquez,Juan Carlos, Montes,Nicolás, Díaz,Erik
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2018
Materias:	Exercise Neoplasms Sirtuins
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000600762
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spelling	oai:scielo:S0034-988720180006007622018-08-24Combatiendo el metabolismo de las células cancerosas mediante la activación de SIRT3 y el ejercicio físicoBórquez,Juan CarlosMontes,NicolásDíaz,Erik Exercise Neoplasms Sirtuins One of the main features of cancer is the high rate of cell proliferation and growth. To do this, cancer cells need to redirect their metabolism mainly towards anaerobic glycolysis and an increased mitochondrial glutamine energy metabolism. Sirtuins are cellular proteins with regulatory functions on metabolic pathways, genomic stability, apoptosis, longevity, inflammation, energy metabolism and oxidative stress. Sirtuins have emerged recently as a potential therapeutic option to treat several chronic diseases including cancer. This review summarizes the tumor suppressor function of Sirtuin 3 (SIRT3), highlighting its repressor effect on glycolytic metabolism, promoting mitochondrial metabolism and oxidative stress reduction. SIRT3 activation by exercise is particularly described since it may represent a potent tool for several types of cancer treatment.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.146 n.6 20182018-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000600762es10.4067/s0034-98872018000600762
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Exercise Neoplasms Sirtuins
spellingShingle	Exercise Neoplasms Sirtuins Bórquez,Juan Carlos Montes,Nicolás Díaz,Erik Combatiendo el metabolismo de las células cancerosas mediante la activación de SIRT3 y el ejercicio físico
description	One of the main features of cancer is the high rate of cell proliferation and growth. To do this, cancer cells need to redirect their metabolism mainly towards anaerobic glycolysis and an increased mitochondrial glutamine energy metabolism. Sirtuins are cellular proteins with regulatory functions on metabolic pathways, genomic stability, apoptosis, longevity, inflammation, energy metabolism and oxidative stress. Sirtuins have emerged recently as a potential therapeutic option to treat several chronic diseases including cancer. This review summarizes the tumor suppressor function of Sirtuin 3 (SIRT3), highlighting its repressor effect on glycolytic metabolism, promoting mitochondrial metabolism and oxidative stress reduction. SIRT3 activation by exercise is particularly described since it may represent a potent tool for several types of cancer treatment.
author	Bórquez,Juan Carlos Montes,Nicolás Díaz,Erik
author_facet	Bórquez,Juan Carlos Montes,Nicolás Díaz,Erik
author_sort	Bórquez,Juan Carlos
title	Combatiendo el metabolismo de las células cancerosas mediante la activación de SIRT3 y el ejercicio físico
title_short	Combatiendo el metabolismo de las células cancerosas mediante la activación de SIRT3 y el ejercicio físico
title_full	Combatiendo el metabolismo de las células cancerosas mediante la activación de SIRT3 y el ejercicio físico
title_fullStr	Combatiendo el metabolismo de las células cancerosas mediante la activación de SIRT3 y el ejercicio físico
title_full_unstemmed	Combatiendo el metabolismo de las células cancerosas mediante la activación de SIRT3 y el ejercicio físico
title_sort	combatiendo el metabolismo de las células cancerosas mediante la activación de sirt3 y el ejercicio físico
publisher	Sociedad Médica de Santiago
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000600762
work_keys_str_mv	AT borquezjuancarlos combatiendoelmetabolismodelascelulascancerosasmediantelaactivaciondesirt3yelejerciciofisico AT montesnicolas combatiendoelmetabolismodelascelulascancerosasmediantelaactivaciondesirt3yelejerciciofisico AT diazerik combatiendoelmetabolismodelascelulascancerosasmediantelaactivaciondesirt3yelejerciciofisico
_version_	1718437010616614912

Combatiendo el metabolismo de las células cancerosas mediante la activación de SIRT3 y el ejercicio físico

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