Remisión espontánea de acromegalia y enfermedad de Cushing en adultos mayores. Casos clínicos

Pituitary diseases such as acromegaly and Cushing's disease require surgical or medical therapy. In some functioning pituitary tumors, a spontaneous remission of hormonal hypersecretion is observed, mainly associated to apoplexy or pituitary infarction. We report the evolution of two female pat...

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Autores principales:	Araya,A. Verónica, Eugenin,Daniela, Lemp,Melchor
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2018
Materias:	Acromegaly Cellular Senescence Pituitary ACTH Hypersecretion Remission Spontaneous
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000700933
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spelling	oai:scielo:S0034-988720180007009332018-09-26Remisión espontánea de acromegalia y enfermedad de Cushing en adultos mayores. Casos clínicosAraya,A. VerónicaEugenin,DanielaLemp,Melchor Acromegaly Cellular Senescence Pituitary ACTH Hypersecretion Remission Spontaneous Pituitary diseases such as acromegaly and Cushing's disease require surgical or medical therapy. In some functioning pituitary tumors, a spontaneous remission of hormonal hypersecretion is observed, mainly associated to apoplexy or pituitary infarction. We report the evolution of two female patients older than 70 years at the time of diagnosis, with multiple comorbidities. In case 1, acromegaly was diagnosed at 74 years of age. Sellar CT scan showed a 10-mm adenoma. During her follow-up, IGF1 levels remained normal. Nine years later, a magnetic resonance (MR) showed a 7-mm adenoma. In case 2, clinical and biochemical diagnosis of Cushing's disease was done being 71 years old. Sellar MR showed a 6-mm adenoma. Three years later, urinary cortisol normalized with no changes in adenoma at MR. Seven years later, she remains without clinical or biochemical signs of hypercortisolism. In both cases, no signs of hemorrhage were observed at MR.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.146 n.7 20182018-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000700933es10.4067/s0034-98872018000700933
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Acromegaly Cellular Senescence Pituitary ACTH Hypersecretion Remission Spontaneous
spellingShingle	Acromegaly Cellular Senescence Pituitary ACTH Hypersecretion Remission Spontaneous Araya,A. Verónica Eugenin,Daniela Lemp,Melchor Remisión espontánea de acromegalia y enfermedad de Cushing en adultos mayores. Casos clínicos
description	Pituitary diseases such as acromegaly and Cushing's disease require surgical or medical therapy. In some functioning pituitary tumors, a spontaneous remission of hormonal hypersecretion is observed, mainly associated to apoplexy or pituitary infarction. We report the evolution of two female patients older than 70 years at the time of diagnosis, with multiple comorbidities. In case 1, acromegaly was diagnosed at 74 years of age. Sellar CT scan showed a 10-mm adenoma. During her follow-up, IGF1 levels remained normal. Nine years later, a magnetic resonance (MR) showed a 7-mm adenoma. In case 2, clinical and biochemical diagnosis of Cushing's disease was done being 71 years old. Sellar MR showed a 6-mm adenoma. Three years later, urinary cortisol normalized with no changes in adenoma at MR. Seven years later, she remains without clinical or biochemical signs of hypercortisolism. In both cases, no signs of hemorrhage were observed at MR.
author	Araya,A. Verónica Eugenin,Daniela Lemp,Melchor
author_facet	Araya,A. Verónica Eugenin,Daniela Lemp,Melchor
author_sort	Araya,A. Verónica
title	Remisión espontánea de acromegalia y enfermedad de Cushing en adultos mayores. Casos clínicos
title_short	Remisión espontánea de acromegalia y enfermedad de Cushing en adultos mayores. Casos clínicos
title_full	Remisión espontánea de acromegalia y enfermedad de Cushing en adultos mayores. Casos clínicos
title_fullStr	Remisión espontánea de acromegalia y enfermedad de Cushing en adultos mayores. Casos clínicos
title_full_unstemmed	Remisión espontánea de acromegalia y enfermedad de Cushing en adultos mayores. Casos clínicos
title_sort	remisión espontánea de acromegalia y enfermedad de cushing en adultos mayores. casos clínicos
publisher	Sociedad Médica de Santiago
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000700933
work_keys_str_mv	AT arayaaveronica remisionespontaneadeacromegaliayenfermedaddecushingenadultosmayorescasosclinicos AT eugenindaniela remisionespontaneadeacromegaliayenfermedaddecushingenadultosmayorescasosclinicos AT lempmelchor remisionespontaneadeacromegaliayenfermedaddecushingenadultosmayorescasosclinicos
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Remisión espontánea de acromegalia y enfermedad de Cushing en adultos mayores. Casos clínicos

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