Fibrosis pulmonar aguda asociada a intoxicación por Paraquat: caso clínico

Paraquat, a non-selective bipyridyl pesticide, is one of the leading causes of death from intoxication in many parts of Asia and America. It is the second most sold herbicide worldwide, being widely used in Chile. Its ingestion generates toxicity due to the release of superoxide radicals, mainly aff...

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Autores principales:	Cartagena,Sebastián, Díaz,Israel, Gutiérrez,Constanza, Dreyse,Jorge, Florenzano,Matías, Palavecino,Marcela, Regueira,Tomás
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2018
Materias:	Paraquat Poisoning Pulmonary Fibrosis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000700938
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spelling	oai:scielo:S0034-988720180007009382018-09-26Fibrosis pulmonar aguda asociada a intoxicación por Paraquat: caso clínicoCartagena,SebastiánDíaz,IsraelGutiérrez,ConstanzaDreyse,JorgeFlorenzano,MatíasPalavecino,MarcelaRegueira,Tomás Paraquat Poisoning Pulmonary Fibrosis Paraquat, a non-selective bipyridyl pesticide, is one of the leading causes of death from intoxication in many parts of Asia and America. It is the second most sold herbicide worldwide, being widely used in Chile. Its ingestion generates toxicity due to the release of superoxide radicals, mainly affecting kidneys, lungs and liver. There is no antidote available. We report a 31 years old male who ingested Paraquat for suicidal purposes. He developed an acute renal and hepatic failure and a rapidly progressive severe respiratory failure with images compatible with acute pulmonary fibrosis. No response to immunosuppressive treatment was observed. He died eight days after admission. The use of cyclophosphamide associated with glucocorticoids could lower risk of death the in these patients, although the pathophysiology of respiratory failure is still under study.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.146 n.7 20182018-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000700938es10.4067/s0034-98872018000700938
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Paraquat Poisoning Pulmonary Fibrosis
spellingShingle	Paraquat Poisoning Pulmonary Fibrosis Cartagena,Sebastián Díaz,Israel Gutiérrez,Constanza Dreyse,Jorge Florenzano,Matías Palavecino,Marcela Regueira,Tomás Fibrosis pulmonar aguda asociada a intoxicación por Paraquat: caso clínico
description	Paraquat, a non-selective bipyridyl pesticide, is one of the leading causes of death from intoxication in many parts of Asia and America. It is the second most sold herbicide worldwide, being widely used in Chile. Its ingestion generates toxicity due to the release of superoxide radicals, mainly affecting kidneys, lungs and liver. There is no antidote available. We report a 31 years old male who ingested Paraquat for suicidal purposes. He developed an acute renal and hepatic failure and a rapidly progressive severe respiratory failure with images compatible with acute pulmonary fibrosis. No response to immunosuppressive treatment was observed. He died eight days after admission. The use of cyclophosphamide associated with glucocorticoids could lower risk of death the in these patients, although the pathophysiology of respiratory failure is still under study.
author	Cartagena,Sebastián Díaz,Israel Gutiérrez,Constanza Dreyse,Jorge Florenzano,Matías Palavecino,Marcela Regueira,Tomás
author_facet	Cartagena,Sebastián Díaz,Israel Gutiérrez,Constanza Dreyse,Jorge Florenzano,Matías Palavecino,Marcela Regueira,Tomás
author_sort	Cartagena,Sebastián
title	Fibrosis pulmonar aguda asociada a intoxicación por Paraquat: caso clínico
title_short	Fibrosis pulmonar aguda asociada a intoxicación por Paraquat: caso clínico
title_full	Fibrosis pulmonar aguda asociada a intoxicación por Paraquat: caso clínico
title_fullStr	Fibrosis pulmonar aguda asociada a intoxicación por Paraquat: caso clínico
title_full_unstemmed	Fibrosis pulmonar aguda asociada a intoxicación por Paraquat: caso clínico
title_sort	fibrosis pulmonar aguda asociada a intoxicación por paraquat: caso clínico
publisher	Sociedad Médica de Santiago
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000700938
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Fibrosis pulmonar aguda asociada a intoxicación por Paraquat: caso clínico

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