Muerte súbita en epilepsia
The risk of sudden unexpected death in patients with epilepsy (SUDEP), is 20 to 25 times greater than in the general population. This increased risk is seen specially in refractory epilepsy, with an incidence of 9:1,000 patients-years. Risk factors have been established based on retrospective studie...
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| Lenguaje: | Spanish / Castilian |
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Sociedad Médica de Santiago
2018
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oai:scielo:S0034-988720180008009022018-10-18Muerte súbita en epilepsiaVelásquez,MauricioMarinis,Alejandro DeBenavides,Evelyn Death, sudden Epilepsy Seizures The risk of sudden unexpected death in patients with epilepsy (SUDEP), is 20 to 25 times greater than in the general population. This increased risk is seen specially in refractory epilepsy, with an incidence of 9:1,000 patients-years. Risk factors have been established based on retrospective studies, finding that the frequency of seizures, specially generalized tonic clonic seizures, is the most important one. The physiopathological mechanism of SUDEP is not yet fully understood. Autonomic system abnormalities, as well as cardiac and respiratory changes have been found. The finding of new molecular biomarkers to identify patients with increased risk should be a priority. Treatment is based in the management of risk factors, although clear recommendations are hard to establish given the low level of evidence.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.146 n.8 20182018-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000800902es10.4067/s0034-98872018000800902 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
Spanish / Castilian |
| topic |
Death, sudden Epilepsy Seizures |
| spellingShingle |
Death, sudden Epilepsy Seizures Velásquez,Mauricio Marinis,Alejandro De Benavides,Evelyn Muerte súbita en epilepsia |
| description |
The risk of sudden unexpected death in patients with epilepsy (SUDEP), is 20 to 25 times greater than in the general population. This increased risk is seen specially in refractory epilepsy, with an incidence of 9:1,000 patients-years. Risk factors have been established based on retrospective studies, finding that the frequency of seizures, specially generalized tonic clonic seizures, is the most important one. The physiopathological mechanism of SUDEP is not yet fully understood. Autonomic system abnormalities, as well as cardiac and respiratory changes have been found. The finding of new molecular biomarkers to identify patients with increased risk should be a priority. Treatment is based in the management of risk factors, although clear recommendations are hard to establish given the low level of evidence. |
| author |
Velásquez,Mauricio Marinis,Alejandro De Benavides,Evelyn |
| author_facet |
Velásquez,Mauricio Marinis,Alejandro De Benavides,Evelyn |
| author_sort |
Velásquez,Mauricio |
| title |
Muerte súbita en epilepsia |
| title_short |
Muerte súbita en epilepsia |
| title_full |
Muerte súbita en epilepsia |
| title_fullStr |
Muerte súbita en epilepsia |
| title_full_unstemmed |
Muerte súbita en epilepsia |
| title_sort |
muerte súbita en epilepsia |
| publisher |
Sociedad Médica de Santiago |
| publishDate |
2018 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000800902 |
| work_keys_str_mv |
AT velasquezmauricio muertesubitaenepilepsia AT marinisalejandrode muertesubitaenepilepsia AT benavidesevelyn muertesubitaenepilepsia |
| _version_ |
1718437019657437184 |