Alta prevalencia de dislipidemias y riesgo aterogénico en una población infanto-juvenil

Background: Dyslipidemias in childhood increase the risk of cardiovascular events in adult life. Aim: To evaluate the prevalence of dyslipidemia and risk of atherogenicity based in the atherogenic index of plasma (AIP) in a sample of school children and adolescents. Material and Methods: Cross-sec...

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Autores principales:	SAPUNAR,JORGE, AGUILAR-FARÍAS,NICOLÁS, NAVARRO,JUAN, ARANEDA,GUSTAVO, CHANDÍA-POBLETE,DAMIAN, MANRÍQUEZ,VÍCTOR, BRITO,ROBERTO, CERDA,ÁLVARO
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2018
Materias:	Cardiovascular Diseases Child Dyslipidemias Risk Factors
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018001001112
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spelling	oai:scielo:S0034-988720180010011122019-03-07Alta prevalencia de dislipidemias y riesgo aterogénico en una población infanto-juvenilSAPUNAR,JORGEAGUILAR-FARÍAS,NICOLÁSNAVARRO,JUANARANEDA,GUSTAVOCHANDÍA-POBLETE,DAMIANMANRÍQUEZ,VÍCTORBRITO,ROBERTOCERDA,ÁLVARO Cardiovascular Diseases Child Dyslipidemias Risk Factors Background: Dyslipidemias in childhood increase the risk of cardiovascular events in adult life. Aim: To evaluate the prevalence of dyslipidemia and risk of atherogenicity based in the atherogenic index of plasma (AIP) in a sample of school children and adolescents. Material and Methods: Cross-sectional study of 208 children aged 10.4 ± 1.0 years (107 women). Demographic data were obtained, and a clinical evaluation was conducted, including pubertal development according to Tanner and anthropometric parameters. A fasting blood sample was obtained to measure total cholesterol (CT), HDL cholesterol (cHDL) and triglycerides (TG), glucose and insulin. LDL cholesterol (cLDL), Non-HDL cholesterol and the indices CT/cHDL, cLDL/cHDL and AIP (log[TG/cHDL]) were calculated. Risk categories according to AIP for the pediatric population were also determined (low: AIP < 0.11, intermediate: AIP 0.11-0.21, high: AIP > 0.21). Results: Thirty eight percent of participants had dyslipidemia, without differences by gender and pubertal development. The frequency of dyslipidemia was significantly higher in children with obesity (54%, p < 0.01) and a waist circumference over percentile 90 (61%; p < 0.01). The later conditions had also higher CT/cHDL, cLDL/cHDL and AIP. According to AIP, 54% of children had a high atherogenicity risk along with alterations in anthropometric parameters and insulin resistance. All anthropometric and insulin resistance parameters were significantly correlated with the AIP. Conclusions: There is a high prevalence of dyslipidemia in the studied population, which is associated with an increased cardiometabolic risk. The indices of atherogenicity and particularly AIP are correlated with nutritional status, abdominal obesity and parameters of insulin resistance.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.146 n.10 20182018-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018001001112es10.4067/S0034-98872018001001112
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Cardiovascular Diseases Child Dyslipidemias Risk Factors
spellingShingle	Cardiovascular Diseases Child Dyslipidemias Risk Factors SAPUNAR,JORGE AGUILAR-FARÍAS,NICOLÁS NAVARRO,JUAN ARANEDA,GUSTAVO CHANDÍA-POBLETE,DAMIAN MANRÍQUEZ,VÍCTOR BRITO,ROBERTO CERDA,ÁLVARO Alta prevalencia de dislipidemias y riesgo aterogénico en una población infanto-juvenil
description	Background: Dyslipidemias in childhood increase the risk of cardiovascular events in adult life. Aim: To evaluate the prevalence of dyslipidemia and risk of atherogenicity based in the atherogenic index of plasma (AIP) in a sample of school children and adolescents. Material and Methods: Cross-sectional study of 208 children aged 10.4 ± 1.0 years (107 women). Demographic data were obtained, and a clinical evaluation was conducted, including pubertal development according to Tanner and anthropometric parameters. A fasting blood sample was obtained to measure total cholesterol (CT), HDL cholesterol (cHDL) and triglycerides (TG), glucose and insulin. LDL cholesterol (cLDL), Non-HDL cholesterol and the indices CT/cHDL, cLDL/cHDL and AIP (log[TG/cHDL]) were calculated. Risk categories according to AIP for the pediatric population were also determined (low: AIP < 0.11, intermediate: AIP 0.11-0.21, high: AIP > 0.21). Results: Thirty eight percent of participants had dyslipidemia, without differences by gender and pubertal development. The frequency of dyslipidemia was significantly higher in children with obesity (54%, p < 0.01) and a waist circumference over percentile 90 (61%; p < 0.01). The later conditions had also higher CT/cHDL, cLDL/cHDL and AIP. According to AIP, 54% of children had a high atherogenicity risk along with alterations in anthropometric parameters and insulin resistance. All anthropometric and insulin resistance parameters were significantly correlated with the AIP. Conclusions: There is a high prevalence of dyslipidemia in the studied population, which is associated with an increased cardiometabolic risk. The indices of atherogenicity and particularly AIP are correlated with nutritional status, abdominal obesity and parameters of insulin resistance.
author	SAPUNAR,JORGE AGUILAR-FARÍAS,NICOLÁS NAVARRO,JUAN ARANEDA,GUSTAVO CHANDÍA-POBLETE,DAMIAN MANRÍQUEZ,VÍCTOR BRITO,ROBERTO CERDA,ÁLVARO
author_facet	SAPUNAR,JORGE AGUILAR-FARÍAS,NICOLÁS NAVARRO,JUAN ARANEDA,GUSTAVO CHANDÍA-POBLETE,DAMIAN MANRÍQUEZ,VÍCTOR BRITO,ROBERTO CERDA,ÁLVARO
author_sort	SAPUNAR,JORGE
title	Alta prevalencia de dislipidemias y riesgo aterogénico en una población infanto-juvenil
title_short	Alta prevalencia de dislipidemias y riesgo aterogénico en una población infanto-juvenil
title_full	Alta prevalencia de dislipidemias y riesgo aterogénico en una población infanto-juvenil
title_fullStr	Alta prevalencia de dislipidemias y riesgo aterogénico en una población infanto-juvenil
title_full_unstemmed	Alta prevalencia de dislipidemias y riesgo aterogénico en una población infanto-juvenil
title_sort	alta prevalencia de dislipidemias y riesgo aterogénico en una población infanto-juvenil
publisher	Sociedad Médica de Santiago
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018001001112
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Alta prevalencia de dislipidemias y riesgo aterogénico en una población infanto-juvenil

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