Asociación entre el polimorfismo rs9939609 del gen FTO con la ingesta energética, macronutrientes y consumo de alcohol en población chilena

Background: Fat-mass-associated-gene (FTO) is associated with higher energy intake and specific food preferences. Aim: To investigate the association of the FTO genotype with energy intake, macronutrient and alcohol consumption. Material and Methods: Four hundred and nine participants of the GENA...

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Autores principales:	Villagrán,Marcelo, Petermann-Rocha,Fanny, Mardones,Lorena, Garrido-Méndez,Alex, Martorell,Miquel, Ulloa,Natalia, Santos,José Luis, Pérez-Bravo,Francisco, Celis-Morales,Carlos
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2018
Materias:	Alpha-Ketoglutarate-Dependent Dioxygenase Diet Energy Intake FTO Genotype
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018001101252
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spelling	oai:scielo:S0034-988720180011012522019-02-13Asociación entre el polimorfismo rs9939609 del gen FTO con la ingesta energética, macronutrientes y consumo de alcohol en población chilenaVillagrán,MarceloPetermann-Rocha,FannyMardones,LorenaGarrido-Méndez,AlexMartorell,MiquelUlloa,NataliaSantos,José LuisPérez-Bravo,FranciscoCelis-Morales,Carlos Alpha-Ketoglutarate-Dependent Dioxygenase Diet Energy Intake FTO Genotype Background: Fat-mass-associated-gene (FTO) is associated with higher energy intake and specific food preferences. Aim: To investigate the association of the FTO genotype with energy intake, macronutrient and alcohol consumption. Material and Methods: Four hundred and nine participants of the GENADIO (Genes, Environment, Diabetes and Obesity) study were included. Energy intake, macronutrient and alcohol consumption were the outcomes of interest. The association of FTO (rs9939609) genotype with these outcomes was investigated using linear regression analyses, adjusting for confounding variables. Results: After adjusting for socio-demographic factors, being a carrier of the risk allele for the FTO gene was associated with a higher energy intake (173 kcal per each extra copy of the risk variant [95% confidence intervals (CI): 45; 301], (P = 0.008). After adjusting for lifestyle factors and body mass index, the association was slightly attenuated but remained significant (144 kcal [95% CI: 14; 274], p = 0.030). Conclusions: The FTO genotype is associated with a higher energy intake.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.146 n.11 20182018-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018001101252es10.4067/S0034-98872018001101252
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Alpha-Ketoglutarate-Dependent Dioxygenase Diet Energy Intake FTO Genotype
spellingShingle	Alpha-Ketoglutarate-Dependent Dioxygenase Diet Energy Intake FTO Genotype Villagrán,Marcelo Petermann-Rocha,Fanny Mardones,Lorena Garrido-Méndez,Alex Martorell,Miquel Ulloa,Natalia Santos,José Luis Pérez-Bravo,Francisco Celis-Morales,Carlos Asociación entre el polimorfismo rs9939609 del gen FTO con la ingesta energética, macronutrientes y consumo de alcohol en población chilena
description	Background: Fat-mass-associated-gene (FTO) is associated with higher energy intake and specific food preferences. Aim: To investigate the association of the FTO genotype with energy intake, macronutrient and alcohol consumption. Material and Methods: Four hundred and nine participants of the GENADIO (Genes, Environment, Diabetes and Obesity) study were included. Energy intake, macronutrient and alcohol consumption were the outcomes of interest. The association of FTO (rs9939609) genotype with these outcomes was investigated using linear regression analyses, adjusting for confounding variables. Results: After adjusting for socio-demographic factors, being a carrier of the risk allele for the FTO gene was associated with a higher energy intake (173 kcal per each extra copy of the risk variant [95% confidence intervals (CI): 45; 301], (P = 0.008). After adjusting for lifestyle factors and body mass index, the association was slightly attenuated but remained significant (144 kcal [95% CI: 14; 274], p = 0.030). Conclusions: The FTO genotype is associated with a higher energy intake.
author	Villagrán,Marcelo Petermann-Rocha,Fanny Mardones,Lorena Garrido-Méndez,Alex Martorell,Miquel Ulloa,Natalia Santos,José Luis Pérez-Bravo,Francisco Celis-Morales,Carlos
author_facet	Villagrán,Marcelo Petermann-Rocha,Fanny Mardones,Lorena Garrido-Méndez,Alex Martorell,Miquel Ulloa,Natalia Santos,José Luis Pérez-Bravo,Francisco Celis-Morales,Carlos
author_sort	Villagrán,Marcelo
title	Asociación entre el polimorfismo rs9939609 del gen FTO con la ingesta energética, macronutrientes y consumo de alcohol en población chilena
title_short	Asociación entre el polimorfismo rs9939609 del gen FTO con la ingesta energética, macronutrientes y consumo de alcohol en población chilena
title_full	Asociación entre el polimorfismo rs9939609 del gen FTO con la ingesta energética, macronutrientes y consumo de alcohol en población chilena
title_fullStr	Asociación entre el polimorfismo rs9939609 del gen FTO con la ingesta energética, macronutrientes y consumo de alcohol en población chilena
title_full_unstemmed	Asociación entre el polimorfismo rs9939609 del gen FTO con la ingesta energética, macronutrientes y consumo de alcohol en población chilena
title_sort	asociación entre el polimorfismo rs9939609 del gen fto con la ingesta energética, macronutrientes y consumo de alcohol en población chilena
publisher	Sociedad Médica de Santiago
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018001101252
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Asociación entre el polimorfismo rs9939609 del gen FTO con la ingesta energética, macronutrientes y consumo de alcohol en población chilena

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