Intoxicación por ácido acetilsalicílico, fisiopatología y manejo

Acetylsalicylic acid (ASA) intoxication is potentially lethal. After ingestion, AAS is rapidly transformed into salicylic acid that dissociates into an hydrogen ion plus salicylate. Salicylate is the main form of AAS in the body and produces multiple alterations. Initially, the stimulation of the ve...

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Autores principales:	Sepúlveda,Rodrigo A., Ortega,Marcos, Donoso,Natalia, Jara,Aquiles
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2018
Materias:	Aspirin Drug Overdose Salicylates Therapeutics
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018001101309
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spelling	oai:scielo:S0034-988720180011013092019-02-13Intoxicación por ácido acetilsalicílico, fisiopatología y manejoSepúlveda,Rodrigo A.Ortega,MarcosDonoso,NataliaJara,Aquiles Aspirin Drug Overdose Salicylates Therapeutics Acetylsalicylic acid (ASA) intoxication is potentially lethal. After ingestion, AAS is rapidly transformed into salicylic acid that dissociates into an hydrogen ion plus salicylate. Salicylate is the main form of AAS in the body and produces multiple alterations. Initially, the stimulation of the ventilatory center promotes a respiratory alkalosis. Then, the mitochondrial dysfunction induced by salicylate, will generate a progressive metabolic acidosis due to the accumulation of ketoacids, lactic acid and dicarboxylic acids among others. Another alterations include hydro electrolytic disorders, gastrointestinal lesions, neurological involvement, ototoxicity and coagulopathy. The correct handling of acetylsalicylic acid intoxication requires an thorough knowledge of its pharmacokinetics and pharmacodynamics. Treatment consists in life support measures, gastric lavage, activated charcoal and urinary alkalization to promote the excretion of salicylates. In some occasions, it will be necessary to start renal replacement therapy as soon as possible.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.146 n.11 20182018-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018001101309es10.4067/S0034-98872018001101309
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Aspirin Drug Overdose Salicylates Therapeutics
spellingShingle	Aspirin Drug Overdose Salicylates Therapeutics Sepúlveda,Rodrigo A. Ortega,Marcos Donoso,Natalia Jara,Aquiles Intoxicación por ácido acetilsalicílico, fisiopatología y manejo
description	Acetylsalicylic acid (ASA) intoxication is potentially lethal. After ingestion, AAS is rapidly transformed into salicylic acid that dissociates into an hydrogen ion plus salicylate. Salicylate is the main form of AAS in the body and produces multiple alterations. Initially, the stimulation of the ventilatory center promotes a respiratory alkalosis. Then, the mitochondrial dysfunction induced by salicylate, will generate a progressive metabolic acidosis due to the accumulation of ketoacids, lactic acid and dicarboxylic acids among others. Another alterations include hydro electrolytic disorders, gastrointestinal lesions, neurological involvement, ototoxicity and coagulopathy. The correct handling of acetylsalicylic acid intoxication requires an thorough knowledge of its pharmacokinetics and pharmacodynamics. Treatment consists in life support measures, gastric lavage, activated charcoal and urinary alkalization to promote the excretion of salicylates. In some occasions, it will be necessary to start renal replacement therapy as soon as possible.
author	Sepúlveda,Rodrigo A. Ortega,Marcos Donoso,Natalia Jara,Aquiles
author_facet	Sepúlveda,Rodrigo A. Ortega,Marcos Donoso,Natalia Jara,Aquiles
author_sort	Sepúlveda,Rodrigo A.
title	Intoxicación por ácido acetilsalicílico, fisiopatología y manejo
title_short	Intoxicación por ácido acetilsalicílico, fisiopatología y manejo
title_full	Intoxicación por ácido acetilsalicílico, fisiopatología y manejo
title_fullStr	Intoxicación por ácido acetilsalicílico, fisiopatología y manejo
title_full_unstemmed	Intoxicación por ácido acetilsalicílico, fisiopatología y manejo
title_sort	intoxicación por ácido acetilsalicílico, fisiopatología y manejo
publisher	Sociedad Médica de Santiago
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018001101309
work_keys_str_mv	AT sepulvedarodrigoa intoxicacionporacidoacetilsalicilicofisiopatologiaymanejo AT ortegamarcos intoxicacionporacidoacetilsalicilicofisiopatologiaymanejo AT donosonatalia intoxicacionporacidoacetilsalicilicofisiopatologiaymanejo AT jaraaquiles intoxicacionporacidoacetilsalicilicofisiopatologiaymanejo
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Intoxicación por ácido acetilsalicílico, fisiopatología y manejo

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