Leucemia de células plasmáticas primaria: experiencia en un hospital público chileno

Background: Primary plasma cell leukemia (pPCL) is uncommon, aggressive and has a different biology than multiple myeloma (MM). Aim: To report the features of patients with pPCL. Material and Methods: Review of databases of the Hematology Department and the Hematology laboratory. Results: Of 178...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mendoza,María Gabriela, Valladares,Ximena, Roa,Macarena, Reyes,Margarita, Osorio,Rocío, Undurraga,María Soledad, Legües,María Eugenia, Cabrera,María Elena, Peña,Camila
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2019
Materias:	Bortezamib Leukemia, Plasma Cell Paraproteinemias
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019000100018
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0034-98872019000100018
record_format	dspace
spelling	oai:scielo:S0034-988720190001000182019-04-03Leucemia de células plasmáticas primaria: experiencia en un hospital público chilenoMendoza,María GabrielaValladares,XimenaRoa,MacarenaReyes,MargaritaOsorio,RocíoUndurraga,María SoledadLegües,María EugeniaCabrera,María ElenaPeña,Camila Bortezamib Leukemia, Plasma Cell Paraproteinemias Background: Primary plasma cell leukemia (pPCL) is uncommon, aggressive and has a different biology than multiple myeloma (MM). Aim: To report the features of patients with pPCL. Material and Methods: Review of databases of the Hematology Department and the Hematology laboratory. Results: Of 178 patients with monoclonal gammopathies, five (2.8%) patients aged 33 to 64 years (three females) had a pPCL. The mean hemoglobin was 7.3 g/dL, the mean white blood cell count was 52,500/mm3, with 58% plasma cells, and the mean platelet count was 83,600/mm3. The mean bone marrow infiltration was 89%, LDH was 2,003 IU/L, serum calcium was 13 mg/dL, and creatinine 1.5 mg/dL. Two patients had bone lesions. Three were IgG, one IgA lambda and one lambda light chain. CD20 was positive in one, CD56 was negative in all and CD117 was negative in 3 cases. By conventional cytogenetic analysis, two had a complex karyotype. By Fluorescence in situ Hybridization, one was positive for TP53 and another for t (11; 14). One patient did not receive any treatment, three patients received VTD PACE and one CTD. None underwent transplant. Three patients are alive. The mean survival was 14 months. Conclusions: These patients with pPCL were younger and had a more aggressive clinical outcome than in multiple myeloma.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.147 n.1 20192019-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019000100018es10.4067/S0034-98872019000100018
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Bortezamib Leukemia, Plasma Cell Paraproteinemias
spellingShingle	Bortezamib Leukemia, Plasma Cell Paraproteinemias Mendoza,María Gabriela Valladares,Ximena Roa,Macarena Reyes,Margarita Osorio,Rocío Undurraga,María Soledad Legües,María Eugenia Cabrera,María Elena Peña,Camila Leucemia de células plasmáticas primaria: experiencia en un hospital público chileno
description	Background: Primary plasma cell leukemia (pPCL) is uncommon, aggressive and has a different biology than multiple myeloma (MM). Aim: To report the features of patients with pPCL. Material and Methods: Review of databases of the Hematology Department and the Hematology laboratory. Results: Of 178 patients with monoclonal gammopathies, five (2.8%) patients aged 33 to 64 years (three females) had a pPCL. The mean hemoglobin was 7.3 g/dL, the mean white blood cell count was 52,500/mm3, with 58% plasma cells, and the mean platelet count was 83,600/mm3. The mean bone marrow infiltration was 89%, LDH was 2,003 IU/L, serum calcium was 13 mg/dL, and creatinine 1.5 mg/dL. Two patients had bone lesions. Three were IgG, one IgA lambda and one lambda light chain. CD20 was positive in one, CD56 was negative in all and CD117 was negative in 3 cases. By conventional cytogenetic analysis, two had a complex karyotype. By Fluorescence in situ Hybridization, one was positive for TP53 and another for t (11; 14). One patient did not receive any treatment, three patients received VTD PACE and one CTD. None underwent transplant. Three patients are alive. The mean survival was 14 months. Conclusions: These patients with pPCL were younger and had a more aggressive clinical outcome than in multiple myeloma.
author	Mendoza,María Gabriela Valladares,Ximena Roa,Macarena Reyes,Margarita Osorio,Rocío Undurraga,María Soledad Legües,María Eugenia Cabrera,María Elena Peña,Camila
author_facet	Mendoza,María Gabriela Valladares,Ximena Roa,Macarena Reyes,Margarita Osorio,Rocío Undurraga,María Soledad Legües,María Eugenia Cabrera,María Elena Peña,Camila
author_sort	Mendoza,María Gabriela
title	Leucemia de células plasmáticas primaria: experiencia en un hospital público chileno
title_short	Leucemia de células plasmáticas primaria: experiencia en un hospital público chileno
title_full	Leucemia de células plasmáticas primaria: experiencia en un hospital público chileno
title_fullStr	Leucemia de células plasmáticas primaria: experiencia en un hospital público chileno
title_full_unstemmed	Leucemia de células plasmáticas primaria: experiencia en un hospital público chileno
title_sort	leucemia de células plasmáticas primaria: experiencia en un hospital público chileno
publisher	Sociedad Médica de Santiago
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019000100018
work_keys_str_mv	AT mendozamariagabriela leucemiadecelulasplasmaticasprimariaexperienciaenunhospitalpublicochileno AT valladaresximena leucemiadecelulasplasmaticasprimariaexperienciaenunhospitalpublicochileno AT roamacarena leucemiadecelulasplasmaticasprimariaexperienciaenunhospitalpublicochileno AT reyesmargarita leucemiadecelulasplasmaticasprimariaexperienciaenunhospitalpublicochileno AT osoriorocio leucemiadecelulasplasmaticasprimariaexperienciaenunhospitalpublicochileno AT undurragamariasoledad leucemiadecelulasplasmaticasprimariaexperienciaenunhospitalpublicochileno AT leguesmariaeugenia leucemiadecelulasplasmaticasprimariaexperienciaenunhospitalpublicochileno AT cabreramariaelena leucemiadecelulasplasmaticasprimariaexperienciaenunhospitalpublicochileno AT penacamila leucemiadecelulasplasmaticasprimariaexperienciaenunhospitalpublicochileno
_version_	1718437041497178112

Leucemia de células plasmáticas primaria: experiencia en un hospital público chileno

Ejemplares similares