Características citogenéticas y detección de anormalidades de alto riesgo en mieloma múltiple
Background: Cytogenetic abnormalities observed in the bone marrow of patients with multiple myeloma (MM) are an important prognostic factor for risk stratification. Aim: To investigate karyotype characteristics and frequency of the high-risk cytogenetic abnormalities t(4;14), t(14;16) and del(17p)...
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| Lenguaje: | Spanish / Castilian |
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Sociedad Médica de Santiago
2019
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| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019000100061 |
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oai:scielo:S0034-988720190001000612019-04-03Características citogenéticas y detección de anormalidades de alto riesgo en mieloma múltipleLegües,María EugeniaMorales,PaulinaValenzuela,MercedesEncina,AndreaMartí,María JoséBascuñán,ClaudiaCornejo,PaulinaPeña,CamilaUndurraga,María Soledad Chromosome Aberrations Cytogenetics Multiple Myeloma Background: Cytogenetic abnormalities observed in the bone marrow of patients with multiple myeloma (MM) are an important prognostic factor for risk stratification. Aim: To investigate karyotype characteristics and frequency of the high-risk cytogenetic abnormalities t(4;14), t(14;16) and del(17p) in Chilean patients with MM. Material and Methods: We studied 30 patients with MM by conventional cytogenetics (CC) and fluorescent in situ hybridization of plasma cells selected using cytoplasmic immunoglobulin staining (cIg-FISH). Results: Overall, the two techniques in combination allowed us to identify clonal genetic abnormalities in 47% of patients. The t(4;14) abnormality was observed in 19% of patients, del(17p) was observed in 10% of patients, and t(14;16) was not detected. Conclusions: Our results showed frequencies of high-risk abnormalities similar to those reported abroad. Cytogenetic studies should be performed routinely for all MM patients at the moment of diagnosis.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.147 n.1 20192019-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019000100061es10.4067/S0034-98872019000100061 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
Spanish / Castilian |
| topic |
Chromosome Aberrations Cytogenetics Multiple Myeloma |
| spellingShingle |
Chromosome Aberrations Cytogenetics Multiple Myeloma Legües,María Eugenia Morales,Paulina Valenzuela,Mercedes Encina,Andrea Martí,María José Bascuñán,Claudia Cornejo,Paulina Peña,Camila Undurraga,María Soledad Características citogenéticas y detección de anormalidades de alto riesgo en mieloma múltiple |
| description |
Background: Cytogenetic abnormalities observed in the bone marrow of patients with multiple myeloma (MM) are an important prognostic factor for risk stratification. Aim: To investigate karyotype characteristics and frequency of the high-risk cytogenetic abnormalities t(4;14), t(14;16) and del(17p) in Chilean patients with MM. Material and Methods: We studied 30 patients with MM by conventional cytogenetics (CC) and fluorescent in situ hybridization of plasma cells selected using cytoplasmic immunoglobulin staining (cIg-FISH). Results: Overall, the two techniques in combination allowed us to identify clonal genetic abnormalities in 47% of patients. The t(4;14) abnormality was observed in 19% of patients, del(17p) was observed in 10% of patients, and t(14;16) was not detected. Conclusions: Our results showed frequencies of high-risk abnormalities similar to those reported abroad. Cytogenetic studies should be performed routinely for all MM patients at the moment of diagnosis. |
| author |
Legües,María Eugenia Morales,Paulina Valenzuela,Mercedes Encina,Andrea Martí,María José Bascuñán,Claudia Cornejo,Paulina Peña,Camila Undurraga,María Soledad |
| author_facet |
Legües,María Eugenia Morales,Paulina Valenzuela,Mercedes Encina,Andrea Martí,María José Bascuñán,Claudia Cornejo,Paulina Peña,Camila Undurraga,María Soledad |
| author_sort |
Legües,María Eugenia |
| title |
Características citogenéticas y detección de anormalidades de alto riesgo en mieloma múltiple |
| title_short |
Características citogenéticas y detección de anormalidades de alto riesgo en mieloma múltiple |
| title_full |
Características citogenéticas y detección de anormalidades de alto riesgo en mieloma múltiple |
| title_fullStr |
Características citogenéticas y detección de anormalidades de alto riesgo en mieloma múltiple |
| title_full_unstemmed |
Características citogenéticas y detección de anormalidades de alto riesgo en mieloma múltiple |
| title_sort |
características citogenéticas y detección de anormalidades de alto riesgo en mieloma múltiple |
| publisher |
Sociedad Médica de Santiago |
| publishDate |
2019 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019000100061 |
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