Mean platelet volume as a prognostic factor for venous thromboembolic disease

ABSTRACT Background: Mean platelet volume (MPV) is a risk factor for cardiovascular and inflammatory diseases. Aim: To evaluate the association between high MPV and 90-day mortality after an episode of venous thromboembolism (VTE). Material and Methods: Retrospective cohort of 594 patients with a...

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Autores principales:	Díaz,Juan Manuel, Boietti,Bruno R., Vazquez,Fernando J., Waisman,Gabriel D., Giunta,Diego H., Rojas,Liliana Paloma, Peuchot,Verónica, Posadas-Martínez,María Lourdes
Lenguaje:	English
Publicado:	Sociedad Médica de Santiago 2019
Materias:	Mean Platelet Volume Venous Thromboembolism Thromboembolism
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019000200145
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spelling	oai:scielo:S0034-988720190002001452019-04-29Mean platelet volume as a prognostic factor for venous thromboembolic diseaseDíaz,Juan ManuelBoietti,Bruno R.Vazquez,Fernando J.Waisman,Gabriel D.Giunta,Diego H.Rojas,Liliana PalomaPeuchot,VerónicaPosadas-Martínez,María Lourdes Mean Platelet Volume Venous Thromboembolism Thromboembolism ABSTRACT Background: Mean platelet volume (MPV) is a risk factor for cardiovascular and inflammatory diseases. Aim: To evaluate the association between high MPV and 90-day mortality after an episode of venous thromboembolism (VTE). Material and Methods: Retrospective cohort of 594 patients with a median age of 73 years (58% women) with a first episode VTE, included in an institutional Thromboembolic Disease registry between 2014 and 2015. MPV values were obtained from the automated blood cell count measured at the moment of VTE diagnosis. Volumes ≥ 11 fL were classified as high. All patients were followed for 90 days to assess survival. Results: The main comorbidities were cancer in 221 patients (37%), sepsis in 172 (29%) and coronary artery disease in 107 (18%). Median MPV was 8 fl (8-9), brain natriuretic peptide 2,000 pg/ml (1,025-3,900) and troponin 40 pg/ml (19.5-75). Overall mortality was 20% (121/594) during the 90 days of follow-up. Thirty three deaths occurred within 7 days and 43 within the first month. The loss of patients from follow-up was 5% (28/594) at 90 days. Mortality among patients with high MP was 36% (23/63). The crude mortality hazard ratio (HR) for high MPV was 2.2 (95% confidence intervals (CI) 1.4-3.5). When adjusted for sepsis, oncological disease, heart disease, kidney failure and surgery, the mortality HR of high MPV was 2.4 (CI95% 1.5-3.9) in the VTE group, 2.3 (CI95% 1.5-4.4) in the deep venous thrombosis group, and 2.9 (CI95% 1.6 −5.6) in the pulmonary embolism group. Conclusions: High MPV is an independent risk factor for mortality following an episode of VTE.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.147 n.2 20192019-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019000200145en10.4067/s0034-98872019000200145
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Mean Platelet Volume Venous Thromboembolism Thromboembolism
spellingShingle	Mean Platelet Volume Venous Thromboembolism Thromboembolism Díaz,Juan Manuel Boietti,Bruno R. Vazquez,Fernando J. Waisman,Gabriel D. Giunta,Diego H. Rojas,Liliana Paloma Peuchot,Verónica Posadas-Martínez,María Lourdes Mean platelet volume as a prognostic factor for venous thromboembolic disease
description	ABSTRACT Background: Mean platelet volume (MPV) is a risk factor for cardiovascular and inflammatory diseases. Aim: To evaluate the association between high MPV and 90-day mortality after an episode of venous thromboembolism (VTE). Material and Methods: Retrospective cohort of 594 patients with a median age of 73 years (58% women) with a first episode VTE, included in an institutional Thromboembolic Disease registry between 2014 and 2015. MPV values were obtained from the automated blood cell count measured at the moment of VTE diagnosis. Volumes ≥ 11 fL were classified as high. All patients were followed for 90 days to assess survival. Results: The main comorbidities were cancer in 221 patients (37%), sepsis in 172 (29%) and coronary artery disease in 107 (18%). Median MPV was 8 fl (8-9), brain natriuretic peptide 2,000 pg/ml (1,025-3,900) and troponin 40 pg/ml (19.5-75). Overall mortality was 20% (121/594) during the 90 days of follow-up. Thirty three deaths occurred within 7 days and 43 within the first month. The loss of patients from follow-up was 5% (28/594) at 90 days. Mortality among patients with high MP was 36% (23/63). The crude mortality hazard ratio (HR) for high MPV was 2.2 (95% confidence intervals (CI) 1.4-3.5). When adjusted for sepsis, oncological disease, heart disease, kidney failure and surgery, the mortality HR of high MPV was 2.4 (CI95% 1.5-3.9) in the VTE group, 2.3 (CI95% 1.5-4.4) in the deep venous thrombosis group, and 2.9 (CI95% 1.6 −5.6) in the pulmonary embolism group. Conclusions: High MPV is an independent risk factor for mortality following an episode of VTE.
author	Díaz,Juan Manuel Boietti,Bruno R. Vazquez,Fernando J. Waisman,Gabriel D. Giunta,Diego H. Rojas,Liliana Paloma Peuchot,Verónica Posadas-Martínez,María Lourdes
author_facet	Díaz,Juan Manuel Boietti,Bruno R. Vazquez,Fernando J. Waisman,Gabriel D. Giunta,Diego H. Rojas,Liliana Paloma Peuchot,Verónica Posadas-Martínez,María Lourdes
author_sort	Díaz,Juan Manuel
title	Mean platelet volume as a prognostic factor for venous thromboembolic disease
title_short	Mean platelet volume as a prognostic factor for venous thromboembolic disease
title_full	Mean platelet volume as a prognostic factor for venous thromboembolic disease
title_fullStr	Mean platelet volume as a prognostic factor for venous thromboembolic disease
title_full_unstemmed	Mean platelet volume as a prognostic factor for venous thromboembolic disease
title_sort	mean platelet volume as a prognostic factor for venous thromboembolic disease
publisher	Sociedad Médica de Santiago
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019000200145
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_version_	1718437045686239232

Mean platelet volume as a prognostic factor for venous thromboembolic disease

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