Importancia de la orientación diagnóstica en hemofilia A adquirida

Acquired hemophilia A (AHA) is a rare and life-threatening autoimmune hemorrhagic disorder where autoantibodies are developed against factor VIII. An early diagnosis is challenging and mandatory: an immediate hemostatic control is required to reduce morbidity and mortality. Laboratory features of AH...

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Autores principales:	Casas Patarroyo,Claudia Patricia, Agudelo López,Claudia Del Pilar, Galvez,Kenny, Lagos Ibarra,Jimmy, Martínez Rojas,Susan, Ibatá Bernal,Linda
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2019
Materias:	Diagnosis Factor VIII Hemophilic A Hemorrhagic Disorders
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019000300334
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spelling	oai:scielo:S0034-988720190003003342019-07-17Importancia de la orientación diagnóstica en hemofilia A adquiridaCasas Patarroyo,Claudia PatriciaAgudelo López,Claudia Del PilarGalvez,KennyLagos Ibarra,JimmyMartínez Rojas,SusanIbatá Bernal,Linda Diagnosis Factor VIII Hemophilic A Hemorrhagic Disorders Acquired hemophilia A (AHA) is a rare and life-threatening autoimmune hemorrhagic disorder where autoantibodies are developed against factor VIII. An early diagnosis is challenging and mandatory: an immediate hemostatic control is required to reduce morbidity and mortality. Laboratory features of AHA are: presence of autoantibodies against factor VIII, prolonged activated partial thromboplastin time (with normal prothrombin time and thrombin time) and decreased factor VIII levels. In some cases, the results of laboratory tests may be incorrect due to errors in analysis, blood extraction or manipulation of samples; also worth of consideration are limitations in the measurement range and low sensitivity of the tests. This review highlights the importance of adequate screening in patients with suspected AHA to make an adequate diagnosis and reduce overall fatal outcomes.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.147 n.3 20192019-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019000300334es10.4067/S0034-98872019000300334
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Diagnosis Factor VIII Hemophilic A Hemorrhagic Disorders
spellingShingle	Diagnosis Factor VIII Hemophilic A Hemorrhagic Disorders Casas Patarroyo,Claudia Patricia Agudelo López,Claudia Del Pilar Galvez,Kenny Lagos Ibarra,Jimmy Martínez Rojas,Susan Ibatá Bernal,Linda Importancia de la orientación diagnóstica en hemofilia A adquirida
description	Acquired hemophilia A (AHA) is a rare and life-threatening autoimmune hemorrhagic disorder where autoantibodies are developed against factor VIII. An early diagnosis is challenging and mandatory: an immediate hemostatic control is required to reduce morbidity and mortality. Laboratory features of AHA are: presence of autoantibodies against factor VIII, prolonged activated partial thromboplastin time (with normal prothrombin time and thrombin time) and decreased factor VIII levels. In some cases, the results of laboratory tests may be incorrect due to errors in analysis, blood extraction or manipulation of samples; also worth of consideration are limitations in the measurement range and low sensitivity of the tests. This review highlights the importance of adequate screening in patients with suspected AHA to make an adequate diagnosis and reduce overall fatal outcomes.
author	Casas Patarroyo,Claudia Patricia Agudelo López,Claudia Del Pilar Galvez,Kenny Lagos Ibarra,Jimmy Martínez Rojas,Susan Ibatá Bernal,Linda
author_facet	Casas Patarroyo,Claudia Patricia Agudelo López,Claudia Del Pilar Galvez,Kenny Lagos Ibarra,Jimmy Martínez Rojas,Susan Ibatá Bernal,Linda
author_sort	Casas Patarroyo,Claudia Patricia
title	Importancia de la orientación diagnóstica en hemofilia A adquirida
title_short	Importancia de la orientación diagnóstica en hemofilia A adquirida
title_full	Importancia de la orientación diagnóstica en hemofilia A adquirida
title_fullStr	Importancia de la orientación diagnóstica en hemofilia A adquirida
title_full_unstemmed	Importancia de la orientación diagnóstica en hemofilia A adquirida
title_sort	importancia de la orientación diagnóstica en hemofilia a adquirida
publisher	Sociedad Médica de Santiago
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019000300334
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Importancia de la orientación diagnóstica en hemofilia A adquirida

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