Caracterización de tumores secretores de hormona de crecimiento de acuerdo al patrón granular y su rol en el pronóstico

Background: Classification of growth hormone (GH) - secreting tumors by the granular pattern might predict their clinical behavior in acromegalic patients. There are several other prognostic factors. Aim: To compare the features at presentation and cure rates of patients with GH secreting tumors a...

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Autores principales:	Valenzuela,Felipe, Villanueva,Pablo, Rojas Z.,David, Gejman,Roger, Huete,Isidro, Zunino,Romina, Díaz,René E., Wohllk,Nelson, Tissera,Claudia, Carrasco,Carmen A.
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2019
Materias:	Acromegaly Growth Hormone-Secreting Pituitary Adenoma Immunohistochemistry Pathology
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019000700852
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spelling	oai:scielo:S0034-988720190007008522019-11-04Caracterización de tumores secretores de hormona de crecimiento de acuerdo al patrón granular y su rol en el pronósticoValenzuela,FelipeVillanueva,PabloRojas Z.,DavidGejman,RogerHuete,IsidroZunino,RominaDíaz,René E.Wohllk,NelsonTissera,ClaudiaCarrasco,Carmen A. Acromegaly Growth Hormone-Secreting Pituitary Adenoma Immunohistochemistry Pathology Background: Classification of growth hormone (GH) - secreting tumors by the granular pattern might predict their clinical behavior in acromegalic patients. There are several other prognostic factors. Aim: To compare the features at presentation and cure rates of patients with GH secreting tumors according to the granular pattern, and to define independent prognostic factors for surgical treatment in these patients. Material and Methods: A retrospective, observational study of 85 active acromegalic patients surgically treated in two medical centers. Results: Seventy-four patients (87%) were classified as having densely granulated (DG) and 11 (13%) as sparsely granulated (SG) tumors. The latter were less active biochemically, had a higher rate of macroadenoma and cavernous sinus invasion and had a lower rate of biochemical cure than the DG group. Several characteristics were associated with disease persistence but only age (Odds ratio (OR) = 0.93) and cavernous sinus invasion (OR = 21.7) were independently associated in the logistic regression model. Conclusions: The sparsely granulated pattern is associated with a more aggressive behavior, but the main determinants of prognosis are age and cavernous sinus invasion.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.147 n.7 20192019-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019000700852es10.4067/S0034-98872019000700852
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Acromegaly Growth Hormone-Secreting Pituitary Adenoma Immunohistochemistry Pathology
spellingShingle	Acromegaly Growth Hormone-Secreting Pituitary Adenoma Immunohistochemistry Pathology Valenzuela,Felipe Villanueva,Pablo Rojas Z.,David Gejman,Roger Huete,Isidro Zunino,Romina Díaz,René E. Wohllk,Nelson Tissera,Claudia Carrasco,Carmen A. Caracterización de tumores secretores de hormona de crecimiento de acuerdo al patrón granular y su rol en el pronóstico
description	Background: Classification of growth hormone (GH) - secreting tumors by the granular pattern might predict their clinical behavior in acromegalic patients. There are several other prognostic factors. Aim: To compare the features at presentation and cure rates of patients with GH secreting tumors according to the granular pattern, and to define independent prognostic factors for surgical treatment in these patients. Material and Methods: A retrospective, observational study of 85 active acromegalic patients surgically treated in two medical centers. Results: Seventy-four patients (87%) were classified as having densely granulated (DG) and 11 (13%) as sparsely granulated (SG) tumors. The latter were less active biochemically, had a higher rate of macroadenoma and cavernous sinus invasion and had a lower rate of biochemical cure than the DG group. Several characteristics were associated with disease persistence but only age (Odds ratio (OR) = 0.93) and cavernous sinus invasion (OR = 21.7) were independently associated in the logistic regression model. Conclusions: The sparsely granulated pattern is associated with a more aggressive behavior, but the main determinants of prognosis are age and cavernous sinus invasion.
author	Valenzuela,Felipe Villanueva,Pablo Rojas Z.,David Gejman,Roger Huete,Isidro Zunino,Romina Díaz,René E. Wohllk,Nelson Tissera,Claudia Carrasco,Carmen A.
author_facet	Valenzuela,Felipe Villanueva,Pablo Rojas Z.,David Gejman,Roger Huete,Isidro Zunino,Romina Díaz,René E. Wohllk,Nelson Tissera,Claudia Carrasco,Carmen A.
author_sort	Valenzuela,Felipe
title	Caracterización de tumores secretores de hormona de crecimiento de acuerdo al patrón granular y su rol en el pronóstico
title_short	Caracterización de tumores secretores de hormona de crecimiento de acuerdo al patrón granular y su rol en el pronóstico
title_full	Caracterización de tumores secretores de hormona de crecimiento de acuerdo al patrón granular y su rol en el pronóstico
title_fullStr	Caracterización de tumores secretores de hormona de crecimiento de acuerdo al patrón granular y su rol en el pronóstico
title_full_unstemmed	Caracterización de tumores secretores de hormona de crecimiento de acuerdo al patrón granular y su rol en el pronóstico
title_sort	caracterización de tumores secretores de hormona de crecimiento de acuerdo al patrón granular y su rol en el pronóstico
publisher	Sociedad Médica de Santiago
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019000700852
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Caracterización de tumores secretores de hormona de crecimiento de acuerdo al patrón granular y su rol en el pronóstico

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