Paraproteínas: claridad en la nebulosa

Hematological neoplasms are tumors of cells in different states of maturation and differentiation. Since monoclonal gammopathies (MG) refer to B mature lymphocyte neoplasms, lymphogenesis should be well known. We must keep in mind that the last stage of maturation of these lymphocytes is the plasma...

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Autor principal:	Peña,Camila
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2019
Materias:	Blood Protein Electrophoresis Paraproteinemias Paraproteins
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019000801036
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spelling	oai:scielo:S0034-988720190008010362019-10-24Paraproteínas: claridad en la nebulosaPeña,Camila Blood Protein Electrophoresis Paraproteinemias Paraproteins Hematological neoplasms are tumors of cells in different states of maturation and differentiation. Since monoclonal gammopathies (MG) refer to B mature lymphocyte neoplasms, lymphogenesis should be well known. We must keep in mind that the last stage of maturation of these lymphocytes is the plasma cell. This is how a MG could appear in the context of a plasma cell neoplasm, such as multiple myeloma or amyloidosis, but also in relation to a lymphoma. A monoclonal peak is produced by mature B lymphocytes or plasma cells that secrete a monoclonal protein (Immunoglobulin), and represents a MG. But it must be emphasized that, in the correct clinical context, a hypogammaglobulinemia can represent a MG as well. Another important point is the understanding and interpretation of requested tests, such as protein electrophoresis (PEP), immunofixation (IFx) or serum free light chains (sFLC). The current MG screening panel includes these three studies (PEF, IFx, sFLC), although a simpler panel measuring PEF and sFLC has also been proposed, but not yet formally validated. Therefore, screening done only with PEP is insufficient.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.147 n.8 20192019-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019000801036es10.4067/S0034-98872019000801036
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Blood Protein Electrophoresis Paraproteinemias Paraproteins
spellingShingle	Blood Protein Electrophoresis Paraproteinemias Paraproteins Peña,Camila Paraproteínas: claridad en la nebulosa
description	Hematological neoplasms are tumors of cells in different states of maturation and differentiation. Since monoclonal gammopathies (MG) refer to B mature lymphocyte neoplasms, lymphogenesis should be well known. We must keep in mind that the last stage of maturation of these lymphocytes is the plasma cell. This is how a MG could appear in the context of a plasma cell neoplasm, such as multiple myeloma or amyloidosis, but also in relation to a lymphoma. A monoclonal peak is produced by mature B lymphocytes or plasma cells that secrete a monoclonal protein (Immunoglobulin), and represents a MG. But it must be emphasized that, in the correct clinical context, a hypogammaglobulinemia can represent a MG as well. Another important point is the understanding and interpretation of requested tests, such as protein electrophoresis (PEP), immunofixation (IFx) or serum free light chains (sFLC). The current MG screening panel includes these three studies (PEF, IFx, sFLC), although a simpler panel measuring PEF and sFLC has also been proposed, but not yet formally validated. Therefore, screening done only with PEP is insufficient.
author	Peña,Camila
author_facet	Peña,Camila
author_sort	Peña,Camila
title	Paraproteínas: claridad en la nebulosa
title_short	Paraproteínas: claridad en la nebulosa
title_full	Paraproteínas: claridad en la nebulosa
title_fullStr	Paraproteínas: claridad en la nebulosa
title_full_unstemmed	Paraproteínas: claridad en la nebulosa
title_sort	paraproteínas: claridad en la nebulosa
publisher	Sociedad Médica de Santiago
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019000801036
work_keys_str_mv	AT penacamila paraproteinasclaridadenlanebulosa
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Paraproteínas: claridad en la nebulosa

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