Risk of late appearance of acute myocardial infartion after carbon monoxide (CO) intoxication

ABSTRACT Background: After acute carbon monoxide intoxication, there may be a higher risk for late adverse cardiac events. However, these patients are usually not followed to monitor the appearance of these effects. Aim: To follow patients seen at an emergency department for carbon monoxide intoxi...

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Autores principales:	Karaman,Serhat, Coskun,Abuzer
Lenguaje:	English
Publicado:	Sociedad Médica de Santiago 2019
Materias:	Carbon Monoxide Emergency Service, Hospital Myocardial Infarction Poisoning Procalcitonin
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019000901128
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spelling	oai:scielo:S0034-988720190009011282020-01-07Risk of late appearance of acute myocardial infartion after carbon monoxide (CO) intoxicationKaraman,SerhatCoskun,Abuzer Carbon Monoxide Emergency Service, Hospital Myocardial Infarction Poisoning Procalcitonin ABSTRACT Background: After acute carbon monoxide intoxication, there may be a higher risk for late adverse cardiac events. However, these patients are usually not followed to monitor the appearance of these effects. Aim: To follow patients seen at an emergency department for carbon monoxide intoxication, monitoring the appearance of myocardial infarction. To assess the predictive value for such complication of serum troponin, carboxyhemoglobin, and procalcitonin levels at the moment of intoxication. Material and Methods: We followed 237 patients receiving emergency care for carbon monoxide intoxication, with a serum carboxyhemoglobin of 5% or more, between 2010 and 2012. Levels of procalcitonin and troponin I were measured. Patients were followed for five years after the intoxication. Results: During the follow up period, 35 patients had a myocardial infarction. These patients had significantly higher carboxyhemoglobin, procalcitonin and troponin I levels at the moment of the intoxication than their counterparts who did not had a myocardial infarction in the follow up. A logistic regression analysis showed that age, carboxyhemoglobin levels, procalcitonin, troponin 1 and length of CO exposure were associated with a higher risk of myocardial infarction. Procalcitonin, troponin and carboxyhemoglobin levels had a high sensitivity and specificity to predict the appearance of myocardial infarction, with high areas under the receiver operating characteristic (ROC) curves. Conclusions: In patients with CO intoxication, carboxyhemoglobin, troponin and procalcitonin levels at the moment of the intoxication are significant predictors of the late appearance of myocardial infarction.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.147 n.9 20192019-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019000901128en10.4067/s0034-98872019000901128
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Carbon Monoxide Emergency Service, Hospital Myocardial Infarction Poisoning Procalcitonin
spellingShingle	Carbon Monoxide Emergency Service, Hospital Myocardial Infarction Poisoning Procalcitonin Karaman,Serhat Coskun,Abuzer Risk of late appearance of acute myocardial infartion after carbon monoxide (CO) intoxication
description	ABSTRACT Background: After acute carbon monoxide intoxication, there may be a higher risk for late adverse cardiac events. However, these patients are usually not followed to monitor the appearance of these effects. Aim: To follow patients seen at an emergency department for carbon monoxide intoxication, monitoring the appearance of myocardial infarction. To assess the predictive value for such complication of serum troponin, carboxyhemoglobin, and procalcitonin levels at the moment of intoxication. Material and Methods: We followed 237 patients receiving emergency care for carbon monoxide intoxication, with a serum carboxyhemoglobin of 5% or more, between 2010 and 2012. Levels of procalcitonin and troponin I were measured. Patients were followed for five years after the intoxication. Results: During the follow up period, 35 patients had a myocardial infarction. These patients had significantly higher carboxyhemoglobin, procalcitonin and troponin I levels at the moment of the intoxication than their counterparts who did not had a myocardial infarction in the follow up. A logistic regression analysis showed that age, carboxyhemoglobin levels, procalcitonin, troponin 1 and length of CO exposure were associated with a higher risk of myocardial infarction. Procalcitonin, troponin and carboxyhemoglobin levels had a high sensitivity and specificity to predict the appearance of myocardial infarction, with high areas under the receiver operating characteristic (ROC) curves. Conclusions: In patients with CO intoxication, carboxyhemoglobin, troponin and procalcitonin levels at the moment of the intoxication are significant predictors of the late appearance of myocardial infarction.
author	Karaman,Serhat Coskun,Abuzer
author_facet	Karaman,Serhat Coskun,Abuzer
author_sort	Karaman,Serhat
title	Risk of late appearance of acute myocardial infartion after carbon monoxide (CO) intoxication
title_short	Risk of late appearance of acute myocardial infartion after carbon monoxide (CO) intoxication
title_full	Risk of late appearance of acute myocardial infartion after carbon monoxide (CO) intoxication
title_fullStr	Risk of late appearance of acute myocardial infartion after carbon monoxide (CO) intoxication
title_full_unstemmed	Risk of late appearance of acute myocardial infartion after carbon monoxide (CO) intoxication
title_sort	risk of late appearance of acute myocardial infartion after carbon monoxide (co) intoxication
publisher	Sociedad Médica de Santiago
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019000901128
work_keys_str_mv	AT karamanserhat riskoflateappearanceofacutemyocardialinfartionaftercarbonmonoxidecointoxication AT coskunabuzer riskoflateappearanceofacutemyocardialinfartionaftercarbonmonoxidecointoxication
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Risk of late appearance of acute myocardial infartion after carbon monoxide (CO) intoxication

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