AL amyloidosis in the Chilean public health system: a pending debt. Multicenter study of the Chilean Monoclonal Gammopathies Cooperative Group

ABSTRACT Background: Immunoglobulin light chain (AL) amyloidosis is a rare and underdiagnosed entity. Aim: To characterize patients with AL amyloidosis in Chilean public health centers. Material and Methods: We conducted a retrospective, multicenter study. Public centers of the Chilean Monoclonal...

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Autores principales:	Peña,Camila, González,José Tomás, López-Vidal,Hernán, Donoso,Javiera, Contreras,Carolina, Vergara,Carmen Gloria, Hojas,Ricardo, Soto,Pablo, Correa,Gonzalo, Valjalo,Ricardo, Ríos,Álvaro, Larrondo,Jorge, Álvarez,Jaime, Rojas,Christine
Lenguaje:	English
Publicado:	Sociedad Médica de Santiago 2019
Materias:	Amyloidosis Bortezomib Multiple Myeloma Paraproteinemias Transplantation
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019001001239
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spelling	oai:scielo:S0034-988720190010012392020-01-16AL amyloidosis in the Chilean public health system: a pending debt. Multicenter study of the Chilean Monoclonal Gammopathies Cooperative GroupPeña,CamilaGonzález,José TomásLópez-Vidal,HernánDonoso,JavieraContreras,CarolinaVergara,Carmen GloriaHojas,RicardoSoto,PabloCorrea,GonzaloValjalo,RicardoRíos,ÁlvaroLarrondo,JorgeÁlvarez,JaimeRojas,Christine Amyloidosis Bortezomib Multiple Myeloma Paraproteinemias Transplantation ABSTRACT Background: Immunoglobulin light chain (AL) amyloidosis is a rare and underdiagnosed entity. Aim: To characterize patients with AL amyloidosis in Chilean public health centers. Material and Methods: We conducted a retrospective, multicenter study. Public centers of the Chilean Monoclonal Gammopathies Cooperative Group were asked to search for patients with AL amyloidosis in their databases. Epidemiological, clinical and laboratory characteristics were evaluated. Results: Forty-two patients aged 22 to 84 years were found. Twenty four percent had localized AL amyloidosis; 64% had a lambda light chain clone; 47% were associated with multiple myeloma and 9% with non-Hodgkin lymphoma. The most commonly involved organ was the kidney (76%). Serum free light chains were measured in 31% and an echocardiogram was performed in 74% of patients. Seventeen percent of patients received only palliative care, 17% were treated with bortezomib, 21% with thalidomide, and 40% with melphalan. No patient was transplanted. The mean overall survival (OS) of the group was 19 months. The 5-year OS was 28%. Conclusions: It is important to obtain these realistic, national data to initiate strategies to improve early diagnosis and proper management of this disease.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.147 n.10 20192019-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019001001239en10.4067/s0034-98872019001001239
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Amyloidosis Bortezomib Multiple Myeloma Paraproteinemias Transplantation
spellingShingle	Amyloidosis Bortezomib Multiple Myeloma Paraproteinemias Transplantation Peña,Camila González,José Tomás López-Vidal,Hernán Donoso,Javiera Contreras,Carolina Vergara,Carmen Gloria Hojas,Ricardo Soto,Pablo Correa,Gonzalo Valjalo,Ricardo Ríos,Álvaro Larrondo,Jorge Álvarez,Jaime Rojas,Christine AL amyloidosis in the Chilean public health system: a pending debt. Multicenter study of the Chilean Monoclonal Gammopathies Cooperative Group
description	ABSTRACT Background: Immunoglobulin light chain (AL) amyloidosis is a rare and underdiagnosed entity. Aim: To characterize patients with AL amyloidosis in Chilean public health centers. Material and Methods: We conducted a retrospective, multicenter study. Public centers of the Chilean Monoclonal Gammopathies Cooperative Group were asked to search for patients with AL amyloidosis in their databases. Epidemiological, clinical and laboratory characteristics were evaluated. Results: Forty-two patients aged 22 to 84 years were found. Twenty four percent had localized AL amyloidosis; 64% had a lambda light chain clone; 47% were associated with multiple myeloma and 9% with non-Hodgkin lymphoma. The most commonly involved organ was the kidney (76%). Serum free light chains were measured in 31% and an echocardiogram was performed in 74% of patients. Seventeen percent of patients received only palliative care, 17% were treated with bortezomib, 21% with thalidomide, and 40% with melphalan. No patient was transplanted. The mean overall survival (OS) of the group was 19 months. The 5-year OS was 28%. Conclusions: It is important to obtain these realistic, national data to initiate strategies to improve early diagnosis and proper management of this disease.
author	Peña,Camila González,José Tomás López-Vidal,Hernán Donoso,Javiera Contreras,Carolina Vergara,Carmen Gloria Hojas,Ricardo Soto,Pablo Correa,Gonzalo Valjalo,Ricardo Ríos,Álvaro Larrondo,Jorge Álvarez,Jaime Rojas,Christine
author_facet	Peña,Camila González,José Tomás López-Vidal,Hernán Donoso,Javiera Contreras,Carolina Vergara,Carmen Gloria Hojas,Ricardo Soto,Pablo Correa,Gonzalo Valjalo,Ricardo Ríos,Álvaro Larrondo,Jorge Álvarez,Jaime Rojas,Christine
author_sort	Peña,Camila
title	AL amyloidosis in the Chilean public health system: a pending debt. Multicenter study of the Chilean Monoclonal Gammopathies Cooperative Group
title_short	AL amyloidosis in the Chilean public health system: a pending debt. Multicenter study of the Chilean Monoclonal Gammopathies Cooperative Group
title_full	AL amyloidosis in the Chilean public health system: a pending debt. Multicenter study of the Chilean Monoclonal Gammopathies Cooperative Group
title_fullStr	AL amyloidosis in the Chilean public health system: a pending debt. Multicenter study of the Chilean Monoclonal Gammopathies Cooperative Group
title_full_unstemmed	AL amyloidosis in the Chilean public health system: a pending debt. Multicenter study of the Chilean Monoclonal Gammopathies Cooperative Group
title_sort	al amyloidosis in the chilean public health system: a pending debt. multicenter study of the chilean monoclonal gammopathies cooperative group
publisher	Sociedad Médica de Santiago
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019001001239
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AL amyloidosis in the Chilean public health system: a pending debt. Multicenter study of the Chilean Monoclonal Gammopathies Cooperative Group

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