Prognostic impact of renal failure recovery in patients with newly diagnosed multiple mieloma
ABSTRACT Background Renal failure (RF) is a common complication in patients with newly diagnosed multiple myeloma (NDMM). Aim To evaluate the frequency of RF in NDMM patients, and the prognostic impact of its reversibility. Material and Methods A retrospective study evaluating demographic and cli...
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| Lenguaje: | English |
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Sociedad Médica de Santiago
2019
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oai:scielo:S0034-988720190011013742020-02-25Prognostic impact of renal failure recovery in patients with newly diagnosed multiple mielomaPEÑA,CAMILAVALLADARES,XIMENAGAJARDO,CLAUDIARUSSO,MOISÉSMORALES,ÁLVAROCORREA,GONZALOVALJALO,RICARDO Bortezomib Kidney Multiple Myeloma Renal Insufficiency ABSTRACT Background Renal failure (RF) is a common complication in patients with newly diagnosed multiple myeloma (NDMM). Aim To evaluate the frequency of RF in NDMM patients, and the prognostic impact of its reversibility. Material and Methods A retrospective study evaluating demographic and clinical characteristics of 154 consecutive patients with NDMM was carried out. Estimated glomerular filtration rate (eGFR) was calculated at the beginning and at the end of the induction therapy. In addition, we evaluated renal responses (RR) according to the International Myeloma Working Group (IMWG) criteria. The induction regimen was based on thalidomide in all cases. Results Fifty-three patients had RF (34.4%). Complete renal response (RR) was achieved in 51%. Three years overall survival in patients without RF, with RF and complete RR, and patients with RF and any other RR, was 66, 47 and 13%, respectively. Median survival was 53, 27 and 6 months, respectively (p < 0.01). In the multivariate analysis, RF and hypercalcemia were independent predictors of a worse outcome. Conclusions Achieving a complete RR in patients with NDMM, is associated with a better survival.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.147 n.11 20192019-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019001101374en10.4067/S0034-98872019001101374 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Bortezomib Kidney Multiple Myeloma Renal Insufficiency |
| spellingShingle |
Bortezomib Kidney Multiple Myeloma Renal Insufficiency PEÑA,CAMILA VALLADARES,XIMENA GAJARDO,CLAUDIA RUSSO,MOISÉS MORALES,ÁLVARO CORREA,GONZALO VALJALO,RICARDO Prognostic impact of renal failure recovery in patients with newly diagnosed multiple mieloma |
| description |
ABSTRACT Background Renal failure (RF) is a common complication in patients with newly diagnosed multiple myeloma (NDMM). Aim To evaluate the frequency of RF in NDMM patients, and the prognostic impact of its reversibility. Material and Methods A retrospective study evaluating demographic and clinical characteristics of 154 consecutive patients with NDMM was carried out. Estimated glomerular filtration rate (eGFR) was calculated at the beginning and at the end of the induction therapy. In addition, we evaluated renal responses (RR) according to the International Myeloma Working Group (IMWG) criteria. The induction regimen was based on thalidomide in all cases. Results Fifty-three patients had RF (34.4%). Complete renal response (RR) was achieved in 51%. Three years overall survival in patients without RF, with RF and complete RR, and patients with RF and any other RR, was 66, 47 and 13%, respectively. Median survival was 53, 27 and 6 months, respectively (p < 0.01). In the multivariate analysis, RF and hypercalcemia were independent predictors of a worse outcome. Conclusions Achieving a complete RR in patients with NDMM, is associated with a better survival. |
| author |
PEÑA,CAMILA VALLADARES,XIMENA GAJARDO,CLAUDIA RUSSO,MOISÉS MORALES,ÁLVARO CORREA,GONZALO VALJALO,RICARDO |
| author_facet |
PEÑA,CAMILA VALLADARES,XIMENA GAJARDO,CLAUDIA RUSSO,MOISÉS MORALES,ÁLVARO CORREA,GONZALO VALJALO,RICARDO |
| author_sort |
PEÑA,CAMILA |
| title |
Prognostic impact of renal failure recovery in patients with newly diagnosed multiple mieloma |
| title_short |
Prognostic impact of renal failure recovery in patients with newly diagnosed multiple mieloma |
| title_full |
Prognostic impact of renal failure recovery in patients with newly diagnosed multiple mieloma |
| title_fullStr |
Prognostic impact of renal failure recovery in patients with newly diagnosed multiple mieloma |
| title_full_unstemmed |
Prognostic impact of renal failure recovery in patients with newly diagnosed multiple mieloma |
| title_sort |
prognostic impact of renal failure recovery in patients with newly diagnosed multiple mieloma |
| publisher |
Sociedad Médica de Santiago |
| publishDate |
2019 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019001101374 |
| work_keys_str_mv |
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